Method of promoting osteogenesis

Abstract

Novel polymer compositions that are useful in the manufacture of medical implants, implants having osteogenic properties and methods of making said implants are disclosed. Polymer compositions comprise a base material including a polymer matrix of resorbable polymer(s) or copolymer(s), and N-methyl-2-pyrrolidone (NMP), wherein NMP is present in an amount imparting osteogenic properties for the composition.

1 . A method of promoting osteogenesis comprising the steps of: 
 providing a resorbable polymer composition comprising a base material including a polymer matrix of resorbable polymer(s) or copolymer(s), and N-methyl-2-pyrrolidone (NMP), wherein NMP is present in an amount imparting osteogenic properties for the composition, and    implanting the resorbable polymer composition into a recipient to promote osteogenesis.    
     
     
         2 - 11 . (canceled)  
     
     
         12 . The method of  claim 1 , wherein NMP is present in an amount between 0.05 and 50 weight- %.  
     
     
         13 . A method of promoting osteogenesis comprising the steps of: 
 selecting polymer(s) or copolymer(s),    adding NMP to the polymer(s) or copolymer(s) in an amount imparting osteogenic properties to the polymer(s) or copolymer(s),    mixing the polymer(s) or copolymer(s) to form a polymer matrix,    forming an implant from the polymer matrix, and    implanting the implant into a recipient to promote osteogenesis.    
     
     
         14 . The method of  claim 1 , wherein the polymer matrix is selected from a group consisting of polyglycolide, polylactides, polycaprolactones, polytrimethylenecarbonates, polyhydroxybutyrates, polyhydroxyvalerates, polydioxanones, polyorthoesters, polycarbonates, polytyrosinecarbonates, polyorthocarbonates, polyalkylene oxalates, polyalkylene succinates, poly(malic acid), poly(maleic anhydride), polypeptides, polydepsipeptides, polyvinylalcohol, polyesteramides, polyamides, polyanhydrides, polyurethanes, polyphosphazenes, polycyanoacrylates, polyfumarates, poly(amino acids), modified polysaccharides, modified proteins and their copolymers, terpolymers or combinations or mixtures or polymer blends thereof.  
     
     
         15 . The method of  claim 1 , wherein the polymer matrix is selected from the group consisting of polyglycolide, poly(L-lactide-co-glycolide), poly(D,L-lactide-co-glycolide), poly(L-lactide), poly(D,L-lactide), poly(L-lactide-co-D,L-lactide), polycaprolactone, poly(L-lactide-co-caprolactone), poly(D,L-lactide-co-caprolactone) polytrimethylenecarbonate, poly(L-lactide-co-trimethylenecarbonate), poly(D,L-lactide-co-trimethylenecarbonate), polydioxanone and their copolymers, terpolymers or combinations or mixtures or polymer blends thereof.  
     
     
         16 . A method of promoting osteogenesis comprising the steps of: 
 selecting polymer(s) or copolymer(s) to form a polymer matrix,    forming an implant from said polymer matrix,    adding NMP to the implant, and    implanting the implant into a recipient to promote osteogenesis.    
     
     
         17 . The method of  claim 16 , wherein NMP is added to the implant preoperatively.