Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof

Abstract

A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.

1 - 40 . (canceled)  
     
     
         41 . A method of manufacturing a sustained drug delivery system, comprising positioning a drug core in a tube, said drug core containing a therapeutically effective amount of an active agent; and 
 cross-sectionally cutting the tube into sections.    
     
     
         42 . A method in accordance with  claim 41 , further comprising forming an outer layer around a portion of a section, said outer layer formed of a material selected from a permeable material and an impermeable material.  
     
     
         43 . A method in accordance with  claim 41 , wherein positioning a drug core comprises positioning a said drug core in a length of tube which is sized and formed of a material so that said length of tube is dimensionally stable during said positioning.  
     
     
         44 . The method according to  claim 42 , wherein the outer layer is formed by dipping, dropping, spraying, or brushing the section with a solution of polymer.  
     
     
         45 . The method according to  claim 41 , wherein the tube is formed of a material selected from a permeable material and an impermeable material.