Methods of treating sepsis

Abstract

The present invention features a method for treating sepsis. The method includes administrating to a subject in need thereof an effective amount of a fused pyrazolyl compound of formula (I): A is H, C 1 ˜C 6 alkyl, or in which n is 0, 1, 2, or 3; each of Ar 1 , Ar 2 , and Ar 3 , independently, is phenyl, pyridinyl, thienyl, furyl, or pyrrolyl; and each of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , independently, is XYZ; or R 1 and R 2 together, R 3 and R 4 together, or R 5 and R 6 together are O(CH 2 ) 1-6 O; in which X is a bond or C 1 ˜C 6 alkylene, Y is a bond, O, S, OC(O), OC(O)(CH 2 ) 1-6 C(O)O, C(O)O, C(O)S, C(O)NH, C(O)NC 1 ˜C 6 alkyl, NH, or NC 1 ˜C 6 alkyl, and Z is H, halogen, CN, NO 2 , or C 1 ˜C 6 alkyl; and provided that one of R 3 and R 4 is not H.

1 - 25 . (canceled)  
     
     
         26 . A compound of formula (I)  
       
         
           
           
               
               
           
         
       
       wherein 
 A is H, C 1 ˜C 6  alkyl, or  
                     
 in which n is 0, 1, 2, or 3;  
 each of Ar 1 , Ar 2 , and Ar 3 , independently, is phenyl, pyridinyl, thienyl, furyl, or pyrrolyl; and  
 each of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , independently, is XYZ; in which X is a bond or C 1 ˜C 6  alkylene, Y is a bond, O, S, OC(O), OC(O)(CH 2 ) 1-6 C(O)O, C(O)O, C(O)S, C(O)NH, C(O)NC 1 ˜C 6  alkyl, NH, or NC 1 ˜C 6  alkyl, and Z is H, halogen, CN, NO 2 , or C 1 ˜C 6  alkyl; provided that optionally, R 1  and R 2  together, or R 5  and R 6  together are O(CH 2 ) 1-6 O; and further provided that X must be C 1 ˜C 6  alkylene, Y must be OC(O)(CH 2 ) 1-6 C(O)O, and Z must be H or C 1 ˜C 6  alkyl in one of R 3  and R 4 .  
 
     
     
         27 . The compound of  claim 26 , wherein A is  
       
         
           
           
               
               
           
         
       
     
     
         28 . The compound of  claim 27 , wherein Ar 1  is phenyl.  
     
     
         29 . The compound of  claim 28 , wherein Ar 2  is furyl.  
     
     
         30 . The compound of  claim 29 , wherein Ar 3  is phenyl.  
     
     
         31 . The compound of  claim 30 , wherein each of R 1 , R 2 , R 5 , and R 6  is H.  
     
     
         32 . The compound of  claim 31 , wherein one of R 3  and R 4  is H.  
     
     
         33 . The compound of  claim 32 , wherein n is 0 or 1.  
     
     
         34 . The compound of  claim 33 , wherein X is CH 2 , Y must be OC(O)CH 2 CH 2 C(O)O, and Z is H in the other of R 3  and R 4 .  
     
     
         35 . (canceled)  
     
     
         36 . The compound of  claim 26 , wherein A is H.  
     
     
         37 . The compound of  claim 26 , wherein Ar 1  is phenyl.  
     
     
         38 . The compound of  claim 37 , wherein Ar 2  is furyl.  
     
     
         39 . The compound of  claim 26 , wherein Ar 2  is furyl.  
     
     
         40 . The compound of  claim 26 , wherein one of R 3  and R 4  is H, and the other is CH 2 OC(O)CH 2 CH 2 C(O)OH.  
     
     
         41 . The compound of  claim 40 , wherein Ar 1  is phenyl.  
     
     
         42 . The compound of  claim 41 , wherein Ar 2  is furyl.  
     
     
         43 . The compound of  claim 42 , wherein A is  
       
         
           
           
               
               
           
         
       
     
     
         44 . The compound of  claim 43 , wherein n is 1 and Ar 3  is phenyl.  
     
     
         45 . The compound of  claim 26 , wherein Ar 1  is thienyl.  
     
     
         46 . The compound of  claim 26 , wherein the compound is