Durable multi-component antibiotic formulation for topical use

Abstract

Disclosed are methods and formulations for the treatment or prevention of infections on mammalian tissues such as skin. Specifically, the methods of this invention involve the in situ formation of a polymeric cyanoacrylate film containing mixed antibiotics over mammalian tissue.

1 - 11 . (canceled)  
     
     
         12 . A method for the treatment or prevention of infections on mammalian tissues which method comprises: 
 (a) identifying bacterially infected mammalian tissue or tissue at risk of such infection;    (b) applying to the mammalian tissue identified in (a) above a sufficient amount of a composition comprising:    from about 50 to 99 weight percent of a polymerizable cyanoacrylate ester based on the total weight of the composition;    an antibacterially effective amount of an antibiotic or mixture of antibiotics which are insoluble in the polymerizable cyanoarcylate ester; and    a sufficient amount of thickening agent which forms a stable suspension or gel in combination with the cyanoacrylate ester and the antibiotic or the mixture of antibiotics; and    (c) polymerizing the cyanoacrylate ester so as to form an adherent polymeric film to the tissue where the composition was applied.