US2005208076A1PendingUtilityA1

Botulinum toxin pharmaceutical composition with enhanced potency

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Assignee: ALLERGAN INCPriority: Feb 8, 2000Filed: Feb 17, 2005Published: Sep 22, 2005
Est. expiryFeb 8, 2020(expired)· nominal 20-yr term from priority
Inventors:Terrence J. Hunt
A61K 9/19A61K 47/36A61K 9/0019A61P 21/00A61K 38/4893A61K 47/183Y02A50/30
65
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Claims

Abstract

A botulinum toxin pharmaceutical formulation free of animal derived proteins, comprising a botulinum toxin and a recombinant albumin, suitable for therapeutic administration to a human patient, and methods for treating patients with various diseases and afflictions with the formulation.

Claims

exact text as granted — not AI-modified
1 - 19 . (canceled)  
     
     
         20 . A process for making a  botulinum  toxin pharmaceutical composition with an enhanced potency, the process comprising the step of combining a  botulinum  toxin and a recombinant human serum albumin, thereby obtaining a  botulinum  toxin pharmaceutical composition with an enhanced potency.  
     
     
         21 . The process of  claim 20  further comprising the step, before the combining step, of obtaining a  botulinum  toxin.  
     
     
         22 . The process of  claim 21  further comprising the step, before the combining step, of obtaining a recombinant albumin.  
     
     
         23 . the process of  claim 20 , wherein the  botulinum  toxin pharmaceutical composition has an enhanced potency with regard to a reference  botulinum  toxin pharmaceutical composition.  
     
     
         24 . the process of  claim 23 , wherein the reference  botulinum  toxin pharmaceutical composition contains a  botulinum  toxin, sodium chloride and human serum albumin.  
     
     
         25 . the process of  claim 23 , wherein the  botulinum  toxin pharmaceutical composition has a potency which is from at least 5% and up to 40% greater than the potency of the reference  botulinum  toxin pharmaceutical composition.  
     
     
         26 . A process for making a  botulinum  toxin pharmaceutical composition, with an enhanced potency the process comprising the steps of: 
 (a) obtaining a  botulinum  toxin;    (b) obtaining a recombinant albumin and;    (c) combining the  botulinum  toxin and the recombinant human serum albumin to thereby obtain a  botulinum  toxin pharmaceutical composition with an enhanced potency.    
     
     
         27 . A  botulinum  toxin pharmaceutical composition made by the process of  claim 20 .  
     
     
         28 . A  botulinum  toxin pharmaceutical composition made by the process of  claim 26.

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