Phosphoryl choline coating compositions

Abstract

A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a DES comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.

1 . A biocompatible polymer having a biodegradable or nondegradable polymeric backbone, comprising: 
 a biodegradable or nondegradable polymer; and    choline or phospholipid moieties.    
     
     
         2 . The biocompatible polymer of  claim 1  wherein the phospholipid moieties comprise a component selected from the group consisting of phosphoryl choline, phosphoryl serine, phosphoryl inositol, di-phosphoryl glycerol, zwitterionic phosphoryl ethanolamine, and combinations thereof.  
     
     
         3 . The biocompatible polymer of  claim 1  wherein the nondegradable polymer comprises monomers selected from the group consisting of methylmethacrylate (MMA), ethylmethacrylate (EMA), butylmethacrylate (BMA), 2-ethylhexylmethacrylate, laurylmethacrylate (LMA), hydroxylethyl methacrylate (HEMA), PEG acrylate (PEGA), PEG methacrylate, 2-methacryloyloxyethylphosphorylcholine (MPC) and n-vinyl pyrrolidone (VP), methacrylic acid (MA), acrylic acid (AA), hydroxypropyl methacrylate (HPMA), hydroxypropylmethacrylamide, 3-trimethylsilylpropyl methacrylate (TMSPMA), and combinations thereof.  
     
     
         4 . The biocompatible polymer of  claim 1  wherein the biodegradable polymer comprises monomers selected from the group consisting of glycolide, lactide, butyrolactone, caprolactone, hydroxyalkanoate, 3-hydroxybutyrate, 4-hydroxybutyrate, 3-hdyroxyvalerate, 3-hydroxyhexanoate, and combinations thereof.  
     
     
         5 . The biocompatible polymer of  claim 1  wherein the biodegradable polymer is selected from the group consisting of polyesters, polyhydroxyalkanoates (PHAs), poly(α-hydroxyacids), poly(β-hydroxyacid) such as poly(3-hydroxybutyrate) (PHB); poly(3-hydroxybutyrate-co-valerate) (PHBV), poly(3-hydroxyproprionate) (PHP), poly(3-hydroxyhexanoate) (PHH), or poly(4-hydroxyacids), poly(4-hydroxybutyrate), poly(4-hydroxyvalerate), poly(4-hydroxyhexanoate), poly(hydroxyvalerate, poly(ester amides) that may optionally contain alkyl; amino acid; PEG and/or alcohol groups, polycaprolactone, polylactide, polyglycolide, poly(lactide-co-glycolide), polydioxanone (PDS), polyorthoester, polyanhydride, poly(glycolic acid-co-trimethylene carbonate), polyphosphoester polyphosphoester urethane, poly(amino acids), polycyanoacrylates, poly(trimethylene carbonate), poly(iminocarbonate), poly(tyrosine carbonates), polycarbonates, poly(tyrosine arylates), polyurethanes, copoly(ether-esters), polyalkylene oxalates, polyphosphazenes, PHA-PEG, and combinations thereof.  
     
     
         6 . The biocompatible polymer of  claim 1  wherein the nondegradable polymer is selected from the group consisting of ethylene vinyl alcohol copolymer (EVOH), polyurethanes, silicones, polyesters, polyolefins, polyisobutylene and ethylene-alphaolefin copolymers, styrene-isobutylene-styrene triblock copolymers, acrylic polymers and copolymers, vinyl halide polymers and copolymers, polyvinyl chloride, polyvinyl ethers, polyvinyl methyl ether, polyvinylidene halides, polyvinylidene fluoride, polyvinylidene chloride, polyfluoroalkenes, polyperfluoroalkenes, polyacrylonitrile, polyvinyl ketones, polyvinyl aromatics, polystyrene, polyvinyl esters, polyvinyl acetate, copolymers of vinyl monomers with each other and olefins, ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, ABS resins, and ethylene-vinyl acetate copolymers, polyamides such as Nylon 66 and polycaprolactam, alkyd resins, polyoxymethylenes; polyimides; polyethers, epoxy resins, rayon, rayon-triacetate, and combinations thereof.  
     
     
         7 . The biocompatible polymer of  claim 1  further comprising a biobeneficial moiety selected from the group consisting of a non-fouling moiety, an anti-thrombogenic moiety, and a combination thereof.  
     
     
         8 . The biocompatible polymer of  claim 7  wherein the non-fouling moiety is selected from the group consisting of PEG, polyalkene oxides, hydroxyethylmethacrylate (HEMA), poly(n-propylmethacrylamide), sulfonated polystyrene, hyaluronic acid, poly(vinyl alcohol), poly(N-vinyl-2-pyrrolidone), sulfonated dextran, and combinations thereof; and the anti-thrombogenic moiety is selected from the group consisting of heparin, salicylate (aspirin), hirudin, flavonoids, NO donor, thrombomodulin, Atrial natriuretic peptide (ANP), and combinations thereof, and combinations thereof.  
     
     
         9 . The biocompatible polymer of  claim 8  wherein heparin is attached to the polymer via a PEG spacer.  
     
     
         10 . The biocompatible polymer of  claim 2  further comprising a biobeneficial moiety selected from the group consisting of a non-fouling moiety, an anti-thrombogenic moiety, and a combination thereof.  
     
     
         11 . The biocompatible polymer of  claim 10  wherein the non-fouling moiety is selected from the group consisting of PEG, polyalkene oxides, hydroxyethylmethacrylate (HEMA), poly(n-propylmethacrylamide), sulfonated polystyrene, hyaluronic acid, poly(vinyl alcohol), poly(N-vinyl-2-pyrrolidone), sulfonated dextran, and combinations thereof; and the anti-thrombogenic moiety is selected from the group consisting of heparin, salicylate (aspirin), hirudin, flavonoids, NO donor, thrombomodulin, Atrial natriuretic peptide (ANP), and combinations thereof, and combinations thereof.  
     
     
         12 . The biocompatible polymer of  claim 11  wherein heparin is attached to the polymer via a PEG spacer.  
     
     
         13 . The biocompatible polymer of  claim 3  further comprising a biobeneficial moiety selected from the group consisting of a non-fouling moiety, an anti-thrombogenic moiety, and a combination thereof.  
     
     
         14 . The biocompatible polymer of  claim 13  wherein the non-fouling moiety is selected from the group consisting of PEG, polyalkene oxides, hydroxyethylmethacrylate (HEMA), poly(n-propylmethacrylamide), sulfonated polystyrene, hyaluronic acid, poly(vinyl alcohol), poly(N-vinyl-2-pyrrolidone), sulfonated dextran, and combinations thereof; and the anti-thrombogenic moiety is selected from the group consisting of heparin, salicylate (aspirin), hirudin, flavonoids, NO donor, thrombomodulin, Atrial natriuretic peptide (ANP), and combinations thereof, and combinations thereof.  
     
     
         15 . The biocompatible polymer of  claim 14  wherein heparin is attached to the polymer via a PEG spacer.  
     
     
         16 . The biocompatible polymer of  claim 5  further comprising a biobeneficial moiety selected from the group consisting of a non-fouling moiety, an anti-thrombogenic moiety, and a combination thereof.  
     
     
         17 . The biocompatible polymer of  claim 16  wherein the non-fouling moiety is selected from the group consisting of PEG, polyalkene oxides, hydroxyethylmethacrylate (HEMA), poly(n-propylmethacrylamide), sulfonated polystyrene, hyaluronic acid, poly(vinyl alcohol), poly(N-vinyl-2-pyrrolidone), sulfonated dextran, and combinations thereof; and the anti-thrombogenic moiety is selected from the group consisting of heparin, salicylate (aspirin), hirudin, flavonoids, NO donor, thrombomodulin, Atrial natriuretic peptide (ANP), and combinations thereof, and combinations thereof.  
     
     
         18 . The biocompatible polymer of  claim 17  wherein heparin is attached to the polymer via a PEG spacer.  
     
     
         19 . The biocompatible polymer of  claim 1  wherein the polymeric backbone is capable of degrading into components which are pharmacologically active and therapeutic to the process of restenosis or Sub-acute thrombosis.  
     
     
         20 . The biocompatible polymer of  claim 1  wherein the polymeric backbone is PolyAspirin™.  
     
     
         21 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 1 .  
     
     
         22 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 2 .  
     
     
         23 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 3 .  
     
     
         24 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 4 .  
     
     
         25 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 5 .  
     
     
         26 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 6 .  
     
     
         27 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 7 .  
     
     
         28 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 8 .  
     
     
         29 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 9 .  
     
     
         30 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 10 .  
     
     
         31 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 11 .  
     
     
         32 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 12 .  
     
     
         33 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 13 .  
     
     
         34 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 14 .  
     
     
         35 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 15 .  
     
     
         36 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 16 .  
     
     
         37 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 17 .  
     
     
         38 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 18 .  
     
     
         39 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 19 .  
     
     
         40 . An implanatable device comprising a coating that comprises the biocompatible polymer of  claim 20 .  
     
     
         41 . The implantable device of  claim 21  wherein the coating further comprises a biobeneficial material selected from the group consisting of a non-fouling polymer, an anti-thrombogenic polymer, and a combination thereof.  
     
     
         42 . The implantable device of  claim 22  wherein the coating further comprises a biobeneficial material selected from the group consisting of a non-fouling polymer, an anti-thrombogenic polymer, and a combination thereof.  
     
     
         43 . The implantable device of  claim 21  wherein the coating further comprises a bioactive agent.  
     
     
         44 . The implantable device of  claim 43  wherein the bioactive agent is selected from the group consisting of proteins, peptides, anti-inflammatory agents, antivirals, anticancer drugs, anticoagulant agents, free radical scavengers, steroidal anti-inflammatory agents, antibiotics, nitric oxide donors, super oxide dismutases, super oxide dismutases mimics, cytostatic agents, prodrugs thereof, co-drugs thereof, and a combination thereof.  
     
     
         45 . The implantable device of  claim 22  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1′-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         46 . The implantable device of  claim 23  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2- hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         47 . The implantable device of  claim 24  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         48 . The implantable device of  claim 25  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         49 . The implantable device of  claim 26  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         50 . The implantable device of  claim 27  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         51 . The implantable device of  claim 28  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         52 . The implantable device of  claim 29  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         53 . The implantable device of  claim 30  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         54 . The implantable device of  claim 31  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         55 . The implantable device of  claim 32  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         56 . The implantable device of  claim 33  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         57 . The implantable device of  claim 34  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2- hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         58 . The implantable device of  claim 35  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         59 . The implantable device of  claim 36  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         60 . The implantable device of  claim 37  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         61 . The implantable device of  claim 38  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         62 . The implantable device of  claim 39  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         63 . The implantable device of  claim 40  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         64 . The implantable device of  claim 41  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         65 . The implantable device of  claim 42  wherein the coating further comprising an agent selected from the group consisting of ABT-578, dexamethasone, clobetasol, paclitaxel, estradiol, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), tacrolimus, sirolimus, sirolimus derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (EVEROLIMUS), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.  
     
     
         66 . A method of treating a human being by implanting in the human being a stent as defined in  claim 21 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         67 . A method of treating a human being by implanting in the human being a stent as defined in  claim 41 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         68 . A method of treating a human being by implanting in the human being a stent as defined in  claim 42 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         69 . A method of treating a human being by implanting in the human being a stent as defined in  claim 43 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         70 . A method of treating a human being by implanting in the human being a stent as defined in  claim 44 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         71 . A method of treating a human being by implanting in the human being a stent as defined in  claim 45 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         72 . A method of treating a human being by implanting in the human being a stent as defined in  claim 46 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         73 . A method of treating a human being by implanting in the human being a stent as defined in  claim 47 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         74 . A method of treating a human being by implanting in the human being a stent as defined in  claim 48 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         75 . A method of treating a human being by implanting in the human being a stent as defined in  claim 49 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         76 . A method of treating a human being by implanting in the human being a stent as defined in  claim 50 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         77 . A method of treating a human being by implanting in the human being a stent as defined in  claim 51 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         78 . A method of treating a human being by implanting in the human being a stent as defined in  claim 52 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         79 . A method of treating a human being by implanting in the human being a stent as defined in  claim 53 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         80 . A method of treating a human being by implanting in the human being a stent as defined in  claim 54 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         81 . A method of treating a human being by implanting in the human being a stent as defined in  claim 55 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         82 . A method of treating a human being by implanting in the human being a stent as defined in  claim 56 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         83 . A method of treating a human being by implanting in the human being a stent as defined in  claim 57 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         84 . A method of treating a human being by implanting in the human being a stent as defined in  claim 58 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         85 . A method of treating a human being by implanting in the human being a stent as defined in  claim 59 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         86 . A method of treating a human being by implanting in the human being a stent as defined in  claim 60 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         87 . A method of treating a human being by implanting in the human being a stent as defined in  claim 61 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         88 . A method of treating a human being by implanting in the human being a stent as defined in  claim 62 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         89 . A method of treating a human being by implanting in the human being a stent as defined in  claim 63 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm; vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         90 . A method of treating a human being by implanting in the human being a stent as defined in  claim 64 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         91 . A method of treating a human being by implanting in the human being a stent as defined in  claim 65 , 
 wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.    
     
     
         92 . A method of preparing a phosphoryl choline (PC) containing polymer or copolymer, comprising: 
 forming a monomer or commoner comprising at least one PC moiety; and    polymerizing the monomer or commoner comprising at least one PC moiety to form the PC containing polymer or copolymer.    
     
     
         93 . A coating composition comprising the polymer of  claim 1 .  
     
     
         94 . A coating composition comprising the polymer of  claim 2 .  
     
     
         95 . A coating composition comprising the polymer of  claim 3 .  
     
     
         96 . A coating composition comprising the polymer of  claim 4 .  
     
     
         97 . A coating composition comprising the polymer of  claim 5 .  
     
     
         98 . A coating composition comprising the polymer of  claim 6 .  
     
     
         99 . A coating composition comprising the polymer of  claim 7.