Calcium-containing tissue strengthening agents and use thereof

Abstract

The present invention has an object to provide an agent for strengthening calcium-containing tissues, which can be safely applied; and its use: The present invention solves the object by providing an agent for strengthening calcium-containing tissues, which comprises one or more flavones, flavonols, flavanones, flavanonols, anthocyanidins, flavanols, chalcones, and aurones.

1 . An agent for strengthening calcium-containing tissue, which comprises one or more compounds having a basic structure represented by any one of General Formulae 1 to 5 and precursors thereof:  
       General Formula 1:  
       
         
           
           
               
               
           
         
       
       where “X” means a single or double bond, while R 1  to R 10  may be substituents,  
       General Formula 2:  
       
         
           
           
               
               
           
         
       
       wherein R 1  to R 10  may be substituents,  
       General Formula 3:  
       
         
           
           
               
               
           
         
       
       wherein R 1  to R 10  may be substituents,  
       General Formula 4:  
       
         
           
           
               
               
           
         
       
       wherein R 1  to R 11  may be substituents,  
       General Formula 5:  
       
         
           
           
               
               
           
         
       
       wherein R 1  to R 10  may be substituents.  
     
     
         2 . The agent of  claim 1 , wherein said compounds are flavones, flavonols, flavanones, flavanonols, anthocyanidins, flavanols, calcones, or precursors thereof.  
     
     
         3 . The agent of  claim 1 , wherein said compounds are in the form of an aglycon, glycoside, polymer or derivative.  
     
     
         4 . The agent of  claim 1 , wherein said compounds are kaempferol, quercetin, α-glycosyl rutin, hersperetin, naringenin, α-glycosyl hesperidin, cyaniding, proanthocyanidin, or catechin.  
     
     
         5 - 7 . (canceled)  
     
     
         8 . The agent of  claim 1 , which further comprises an isoflavone.  
     
     
         9 . The agent of  claim 8 , wherein said isoflavone is an ipriflavone or isoflavone from soy bean.  
     
     
         10 . The agent of  claim 8 , wherein said isoflavone is in the form of an aglycon, glycoside, polymer, or derivative.  
     
     
         11 . The agent of any  claim 1 , which further comprises one or more members selected from the group consisting of mineral, substance having mineral absorption-promoting activity, oligosaccharide, and vitamin.  
     
     
         12 . The agent of  claim 11 , wherein said minerals are a calcium compound, magnesium compound, and/or a mixture thereof.  
     
     
         13 . The agent of  claim 11 , wherein said substance having mineral absorption-promoting activity are casein, oligosaccharide, and mixture thereof.  
     
     
         14 . The agent of  claim 11 , wherein said oligosaccharides are fractooligosaccharide, isomaltoligosaccharide, xylooligosaccharide, lactosucrose, soybean oligosaccharide, α,α-trehalose, and/or α,β-trehalose.  
     
     
         15 . The agent of  claim 11 , wherein said vitamins are vitamin D, vitamin K, L-ascorbic acid, and/or derivatives thereof.  
     
     
         16 . In a food, beverage, cosmetic, or pharmaceutical composition comprising a food, beverage, cosmetic or pharmaceutical component, the improvement 
 wherein said food, beverage, cosmetic or pharmaceutical composition further, comprises the agent of  claim 1 .    
     
     
         17 . The food or beverage of  claim 16 , which is a health food.