Release control type formed product

Abstract

In order to provide a molded product capable of manifesting a desired release control pattern of an effective ingredient by direct tabletting method, a controlled release molded product was devised characterized in having an outer layer and a plurality of cores or a core partially provided with constrictions and portions that can be substantially identified as a plurality of cores and controlling release of the effective ingredient contained in the core portion according to the distance from the outside of the molded product to individual core. The molded product of the present invention can also be used in a dividable controlled release molded product in which the release property remains unchanged after division by providing a structure coupling a plurality of unit molded products and ensuring that the distance from the division surface to the core is sufficiently longer than the distance from the external reference plane on the molded product surface that stipulates the distance from the outside of the molded product to the core. It is possible to readily manufacture the molded product of the present invention using integral compression molding means having a double-structured punch—punch consisting of a core punch and an outer punch enclosing part or whole of the outer perimeter of the core punch—above and below a die.

1 - 8 . (canceled)  
   
   
       9 . A controlled release molded product comprising an outer layer and a plurality of cores, wherein release of an effective ingredient contained in the cores is controlled by varying a distance from an outside of the molded product to each of the plurality of cores arranged at a specific position.  
   
   
       10 . The controlled release molded product of  claim 9  further comprising a coupling portion that joins the controlled release molded product to a plurality of other controlled release molded products that each comprise a core, wherein division of all of the controlled release molded products from each other along the coupling portion creates a division surface wherein a distance from the division surface to any core is longer than a distance from the outermost surface to the core of the molded product before division.  
   
   
       11 . The controlled release molded product of  claim 9 , wherein the release of the effective ingredient is further controlled by a property of a filler ingredient in the outer layer.  
   
   
       12 . The controlled release molded product of  claim 11 , wherein the filler ingredient in the outer layer is a matrix-type sustained release base.  
   
   
       13 . The controlled release molded product of  claim 9 , wherein no filler ingredient having a release delaying property is contained in the core.  
   
   
       14 . The controlled release molded product of  claim 9 , having a plurality of pulsed release properties.  
   
   
       15 . The controlled release molded product of  claim 9 , wherein the molded product is manufactured by a compression molding method alone.  
   
   
       16 . A controlled release molded product comprising an outer layer and a core having at least one constriction such that a plurality of cores are substantially formed, wherein release of an effective ingredient, contained in the core portion, is controlled by a distance from an outside of the molded product to each of the plurality of cores substantially formed by the at least one constriction of the core arranged at a specific position.  
   
   
       17 . The controlled release molded product of  claim 16 , wherein no filler ingredient having a release delaying property is contained in the core.  
   
   
       18 . The controlled release molded product of  claim 16 , having a plurality of pulsed release properties.  
   
   
       19 . The controlled release molded product of  claim 16 , wherein the molded product is manufactured by a compression molding method alone.  
   
   
       20 . The controlled release molded product of  claim 16 , wherein the release of the effective ingredient is further controlled by a property of a filler ingredient in the outer layer.  
   
   
       21 . The controlled release molded product of  claim 20 , wherein the filler ingredient in the outer layer is a matrix-type sustained release base.  
   
   
       22 . The controlled release molded product of  claim 16  further comprising a coupling portion that joins the controlled release molded product to a plurality of other controlled release molded products that each comprise a core, wherein division of all of the controlled release molded products from each other along the coupling portion creates a division surface wherein a distance from the division surface to any core is longer than a distance from the outermost surface to the core of the molded product before division.  
   
   
       23 . A controlled release molded product comprising a plurality of controlled release units each having an outermost surface and being joined by coupling portions, with each unit comprising an outer layer and at least one core at a specific position that comprises an effective ingredient having a release pattern that is controlled by a distance from the core to the outermost surface, the distance being shorter than the shortest length between the core and a surface created by separation of the units from each other along the coupling portions.  
   
   
       24 . The controlled release molded product of  claim 23 , wherein at least one of the cores comprises a constriction that substantially forms a plurality of cores from the original core.  
   
   
       25 . The controlled release molded product of  claim 23 , wherein the release of the effective ingredient is further controlled by a property of a filler ingredient in the outer layer.  
   
   
       26 . A method of making a molded product, the method comprising preparing a unit having an outer layer and at least one core disposed at a specific position in the outer layer to define a distance from the at least one core to the outside of the outer layer, and controlling release of the effective ingredient in the core by selecting a material for the outer layer and selecting the distance.  
   
   
       27 . The method of  claim 26 , wherein the core is made with at least one constriction.