Non-systemic control of parasites

Abstract

Use of agonists and antagonists of the nicotinergic acetylcholine receptors of insects for the non-systemic control of parasitic insects, such as fleas, lice and flies, on humans and on animals.

1 - 9 . (canceled)  
     
     
         10 . A method for non-systemically controlling a parasitic insect selected from fleas and lice on a human or animal, said method comprising contacting said parasitic insect with an effective amount therefor of a compound of the formula:  
       
         
           
           
               
               
           
         
       
       wherein 
 n represents 1 or 2;  
 Subst. represents halogen;  
 A represents hydrogen or alkyl having 1 to 4 carbon atoms; and  
 Z represents optionally substituted alkyl;  
 E represents NO 2  or CN; and  
 X represents —CH═ or —N═;  
 wherein said contacting of said parasitic insect with said compound is effected by: 
 a) topically applying said compound to the dermis of said human or animal; or  
 b) contacting the dermis of said human or animal with an article containing said compound;  
 
 and wherein said contacting of said parasitic insect with said compound does not result in said compound being systemically distributed within said human or animal.  
 
     
     
         11 . The method according to  claim 10 , which comprises contacting said parasitic insect with the compound:  
       
         
           
           
               
               
           
         
       
     
     
         12 . The method according to  claim 10 , wherein the animal is a dog or cat infested with fleas.  
     
     
         13 . The method according to  claim 12 , wherein said contacting is effected by applying said compound topically to the dermis of said dog or cat by a pour-on or spot-on method.  
     
     
         14 . The method according to  claim 12 , wherein said contacting is effected by contacting the dermis of said dog or cat with an article containing said compound.  
     
     
         15 . The method according to  claim 10 , which is carried out on a human, and the human is infected with lice.