Use of creatine or creatine compounds for skin preservation

Abstract

The present invention relates to the use of creatine compounds such as, for example, creatine, creatine phosphate or analogs of creatine, such as creatine-pyruvate, creatine-ascorbate, cyclocreatine, 3 guanidinopropionic acid, guanidinoacetate, homocyclocreatine, guanidino benzoates as energy generating systems and antioxidants for preservation of skin against adverse aging effects and damage secondary to insults such as harmful sun radiations, stress and fatigue. The creatine compounds which can be used in the present method include (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) molecules that mimic the biological activity of creatine (3) molecules that modulate the creatine kinase system.

1 . A cosmetic composition comprising an effective amount of a creatine compound, a cosmetically acceptable carrier, and one or more cosmetic adjuvants.  
     
     
         2 . The cosmetic composition of  claim 1 , wherein said cosmetic composition is formulated as a foundation.  
     
     
         3 . The cosmetic composition of  claim 1 , wherein said cosmetic composition further comprises humectants, proteins, polypeptides, preservatives or alkaline agents.  
     
     
         4 . The cosmetic composition of  claim 1 , wherein said effective amount is effective to treat skin damage resulting from sun radiation, stress, fatigue, aging or free radicals  
     
     
         5 . The cosmetic composition of  claim 1 , wherein said cosmetic adjuvant is a dye, opacifier, pigment, or a perfume.  
     
     
         6 . The cosmetic composition of  claim 1 , wherein said creatine compound is creatine, creatine citrate, creatine ascorbate, cyclocreatine, or creatine phosphate.  
     
     
         7 . The cosmetic composition of  claim 1 , further comprising administering camitine or CoQ10.