Valency platform molecules comprising carbamate linkages

Abstract

This invention pertains generally to valency molecules, such as valency platform molecules which act as scaffolds to which one or more molecules may be covalently tethered to form a conjugate. More particularly, the present invention pertains to valency platform molecules which comprise a carbamate linkage (i.e., —O—C(═O)—N<). In one aspect, the present invention pertains to valency platforms comprising carbamate linkages, which molecules have the structure of any one of Formulae I, II, or III, shown in FIG. 1. In one aspect, the present invention pertains to valency platforms comprising carbamate linkages, which molecules have the structure of any one of Formulae IV, V, or VI, shown in FIG. 8. The present invention also pertains to methods of preparing such valency platform molecules, conjugates comprising such valency platform molecules, and methods of preparing such conjugates.

1 - 37 . (canceled)  
   
   
       38 . A composition comprising valency platform molecules, wherein each said valency platform molecule comprises at least 2 carbamate linkages and at least 4 reactive conjugating functional groups; and 
 wherein said valency platform molecules have a polydispersity less than about 1.2.    
   
   
       39 . The composition of  claim 38 , wherein said valency platform molecules have a polydispersity less than about 1.07.  
   
   
       40 . The composition of  claim 38 , wherein each said valency platform molecules comprises at least 4 carbamate linkages and at least 8 reactive functional groups.  
   
   
       41 . The composition of  claim 38 , wherein each said valency platform molecule comprises at least 4 identical reactive conjugating functional groups.  
   
   
       42 . The composition of  claim 38 , wherein each said valency platform molecule comprises 2 to 32 carbamate linkages and 4 to 64 reactive functional groups.  
   
   
       43 . The composition of  claim 38 , wherein comprising said valency platform molecules linked via said reactive functional groups to one or more biologically active molecules.  
   
   
       44 . A composition comprising valency molecules, wherein each said valency molecule comprises at least two branches and at least four terminal groups; 
 wherein each said valency molecule comprises at least 2 carbamate linkages; and    wherein said valency molecules have a polydispersity less than about 1.2.    
   
   
       45 . The composition of  claim 44 , wherein said valency molecules have a polydispersity less than about 1.07.  
   
   
       46 . The composition of  claim 44 , wherein said valency molecules comprise at least 4 carbamate linkages, at least 4 branches and at least 8 terminal groups.