Compound and method of treatment for fungal pathologies of the oral cavity

Abstract

The broadest aspect of the invention is a composition and method of treatment of fungal pathologies of the oral cavity or fungal growth on the surface of dentures. A preferred embodiment of the is a pharmacologically effective amount of a peptide selected from the group of peptides with a C-terminal sequence consisting of KPV, HFRWGKPV, and SYSMEHFRWGKPV in combination with a therapeutically effective amount of a fungicide selected from the group consisting of: itraconazole, econazole, ketoconazole, miconazole and fluconazole. Another embodiment of the invention is a method for treating fungal pathologies of the of oral cavity and dentures by application of a pharmacologically effective amount of a peptide selected from the group of peptides with a C-terminal sequence consisting of KPV, HFRWGKPV, and SYSMEHFRWGKPV in combination with a therapeutically effective amount of a fungicide selected from the group consisting of itraconazole, econazole, ketoconazole, miconazole and fluconazole. In yet another embodiment of the invention these peptides are used in combination with a therapeutically effective amount of gram positive and/or gram negative antibiotics.

1 . A pharmaceutical composition for the treatment of oral infections comprising a therapeutically effective amount of a peptide selected from the group consisting of KPV (SEQ ID NO: 1), VPK-Ac-CC-Ac-KPV (SEQ ID NO: 4) and HFRWGKPV (SEQ ID NO: 2) and combinations thereof in combination with a therapeutically effective amount of a fungicide and a therapeutically effective amount of an antibiotic.  
     
     
         2 . The composition of  claim 1  wherein said fungicide is selected from the group consisting of itraconazole, econazole, ketoconazole, miconazole and fluconazole.  
     
     
         3 . The composition of  claim 1  wherein said antibiotic is selected from the group consisting of: aminglycosides, amoxicillin, ampicillin, azithramycin, erythromycin, nafcillin, penecillin, quinupuristin dalfopristin and vancomycin.  
     
     
         4 . The composition of  claim 3  wherein said antibiotic is directed to gram-positive bacteria.  
     
     
         5 . The composition of  claim 3  wherein said antibiotic is directed to gram-negative bacteria.  
     
     
         6 . The pharmaceutical composition of  claim 1  further solvated in a carrier.  
     
     
         7 . The composition of  claim 6  wherein the carrier is selected from the group consisting of: creams, gels, mouthwashes, toothpastes, tablets, and atomized sprays.  
     
     
         8  The composition of  claim 1  wherein the concentration of said peptide is at least 1 0 −12 M.  
     
     
         9 . A method of treatment of oral infections comprising application of a composition comprising a therapeutically effective amount of a peptide selected from the group consisting of KPV (SEQ ID NO: 1), VPK-Ac-CC-Ac-KPV (SEQ ID NO: 4) and HFRWGKPV (SEQ ID NO: 2) and combinations thereof in combination with a therapeutically effective amount of a fungicide and a therapeutically effective amount of an antibiotic.  
     
     
         10 . The method of  claim 9  wherein said fungicide is selected consisting of: itraconazole, econazole, ketoconazole, miconazole and fluconazole.  
     
     
         11 . The method of  claim 9  wherein the antibiotics are selected from the group consisting of aminglycosides, amoxicillin, ampicillin, azithramycin, erythromycin, nafcillin, penecillin, quinupuristin dalfopristin and vancomycin.  
     
     
         12 . The method of  claim 11  wherein said antibiotic is directed to gram-positive bacteria.  
     
     
         13 . The method of  claim 11  wherein said antibiotic is directed to gram-negative bacteria.  
     
     
         14 . The method of  claim 9  wherein the composition is solvated in a carrier.  
     
     
         15 . The method of  claim 14  wherein the carrier is selected from the group consisting of: creams, gels, mouthwashes, toothpaste, tablets, and atomized sprays.  
     
     
         16 . The method of  claim 9  wherein the concentration of said peptide is at least 10 −12 M.  
     
     
         17 . The method of  claim 9  wherein the administration is selected from the group consisting of oral, anal, parenteral, topical, central and through any other mucous membrane.  
     
     
         18  A method of treating oral candidiasis comprising application of a therapeutically effective amount of a peptide selected from the group consisting of KPV (SEQ ID NO: 1), VPK-Ac-CC-Ac-KPVD (SEQ ID NO: 4) and HFRWGKPV (SEQ ID NO: 2) and combinations thereof in combination with a therapeutically effective amount of a fungicide.