US2005233349A1PendingUtilityA1
Crystal structure of ribosomal protein L11/GTPase activating region rRNA and uses thereof
Est. expiryMay 13, 2019(expired)· nominal 20-yr term from priority
C07K 2299/00G01N 2500/04G16B 20/00G01N 2500/20G01N 33/6803A61P 31/04C07K 14/47G16B 15/00G16B 20/30G16B 15/30
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Claims
Abstract
The present invention is broadly directed to methods of screening ribosomal protein L 11 /GTPase activating region (GAR) RNA-modulating compounds by using information from the high-resolution structure of the L 11 /GAR complex. The methods are useful in identifying compounds useful for anti-bacterial treatments.
Claims
exact text as granted — not AI-modified1 . A method for identifying a potential modulator of ribosomal protein L11/GAR activity, comprising the steps of:
a. using a three-dimensional structure of the L11/GAR complex as defined by atomic coordinates of the L11/GAR according to Table II; b. employing said three-dimensional structure to design or select said potential modulator; c. providing said potential modulator; and d. contacting said potential modulator with L11/GAR to determine the ability of said potential modulator to modulate L11/GAR activity.
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