High concentration topical insecticides containing pyrethroids

Abstract

A topical insecticide preparation is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The topical insecticide contains a combination of a first pyrethroid insecticide effective for killing fleas, a second pyrethroid insecticide effective for killing ticks, and an insect growth regulator (IGR). The topical insecticide preparation can be packaged together or packaged so that the first and second pyrethroid insecticides are stored separately prior to administration of the insecticide preparation to the animal. The combination of the first and second pyrethroid insecticides with an insect growth regulator results in an insecticide preparation formulated to have enhanced insecticidal activity against fleas and ticks compared to the effectiveness of the first and second insecticides used alone. Further, the combination of the first and second pyrethroid insecticides with an insect growth regulator produces an insecticide preparation having enhanced insecticidal activity against fleas and ticks while advantageously minimizing the total amount of insecticide needed for its effectiveness.

1 . An insecticidal preparation, comprising a first insecticide composition in an insecticidally effective amount to kill fleas, a second insecticide composition in an insecticidally effective amount to kill ticks, the first composition packaged in a manner in which it is separated from the second composition, in order to prevent interaction with the second composition prior to administration of the insecticide preparation, and an insect growth inhibiting effective amount of an insect growth regulator (IGR) component packaged with either the first or the second composition.  
     
     
         2 . The insecticidal preparation of  claim 1 , wherein the first insecticide composition is packaged in a first chamber, and the second insecticide composition is packaged in a second chamber, wherein the first chamber and the second chamber are packaged together but separated by at least one barrier which prevents interaction between the first and second insecticide compositions prior to administration of the insecticide preparation.  
     
     
         3 . The insecticidal preparation of  claim 2 , wherein the first chamber and the second chamber are attached or encompassed by a container.  
     
     
         4 . The insecticidal preparation of  claim 1 , wherein the first insecticide component comprises permethrin or phenothrin.  
     
     
         5 . The insecticidal preparation of  claim 4 , wherein the second insecticide component comprises an insecticidal (tetrahydro-3-furanyl) methylamine derivative or a chloronicotinyl insecticide.  
     
     
         6 . The insecticidal preparation of  claim 5 , wherein the second insecticide component comprises dinotefuran.  
     
     
         7 . The insecticidal preparation of  claim 6 , wherein the first insecticide is permethrin.  
     
     
         8 . The insecticidal preparation of  claim 6 , wherein the first insecticide is phenothrin.  
     
     
         9 . The insecticidal preparation of  claim 7 , wherein the IGR component comprises pyriproxyfen.  
     
     
         10 . The insecticidal preparation of  claim 7 , wherein the IGR component comprises methoprene.  
     
     
         11 . The insecticidal preparation of  claim 8 , wherein the IGR component comprises pyriproxyfen.  
     
     
         12 . The insecticidal preparation of  claim 8 , wherein the IGR component comprises methoprene.  
     
     
         13 . The insecticidal preparation of  claim 4 , wherein the second insecticide component comprises acetamiprid.  
     
     
         14 . The insecticidal preparation of  claim 13 , wherein the first insecticide is permethrin.  
     
     
         15 . The insecticidal preparation of  claim 13 , wherein the first insecticide is phenothrin.  
     
     
         16 . The insecticidal preparation of  claim 14 , wherein the IGR component comprises pyriproxyfen.  
     
     
         17 . The insecticidal preparation of  claim 14 , wherein the IGR component comprises methoprene.  
     
     
         18 . The insecticidal preparation of  claim 15 , wherein the IGR component comprises pyriproxyfen.  
     
     
         19 . The insecticidal preparation of  claim 15 , wherein the IGR component comprises methoprene.  
     
     
         20 . The insecticidal preparation of  claim 1 , wherein the preparation further comprises an effective amount of triphenyl phosphate (TPP) to enhance the efficacy of the first or second insecticide composition.  
     
     
         21 . The insecticidal preparation of  claim 9 , wherein the preparation comprises about 40 to 65% permethrin, about 5 to 20% dinotefuran, and about 1 to 2.5% pyriproxyfen.  
     
     
         22 . The insecticidal preparation of  claim 11 , wherein the preparation comprises about 45 to 65% phenothrin, about to 20% dinotefuran, and about 1 to 2.5% pyriproxyfen.  
     
     
         23 . The insecticidal preparation of  claim 16 , wherein the preparation comprises about 40 to 65% permethrin, about 5 to 50% acetamiprid, and about 0.5 to 5% pyriproxyfen.  
     
     
         24 . The insecticidal preparation of  claim 18 , wherein the preparation comprises about 50 to 90% phenothrin, about 5 to 50% acetamiprid and about 0.5 to 5% pyriproxyfen.  
     
     
         25 . The insecticidal preparation of  claim 1 , wherein the preparation is effective to achieve at least a 80% kill rate for fleas and at least a 80% kill rate for ticks.  
     
     
         26 . The insecticidal preparation of  claim 25 , wherein the preparation is effective to achieve at least a 90% kill rate for fleas and at least a 90% kill rate for ticks.  
     
     
         27 . The insecticidal preparation of  claim 1 , wherein the formulation is not irritating to dogs and is effective to kill ticks and fleas with applications of less than 10 ml to a dog.  
     
     
         28 . The insecticidal preparation of  claim 1 , wherein one application of the preparation is effective to kill fleas and ticks for one month.  
     
     
         29 . A method for controlling insect infestation in an animal, the method comprising applying the insecticidal preparation of  claim 1  to the animal.  
     
     
         30 . The method of  claim 29 , wherein the preparation is packaged in two separate containers.  
     
     
         31 . The method of  claim 29 , wherein the preparation is packaged in one container encompassing the first and second chambers.  
     
     
         32 . The method of  claim 29 , wherein the first and second chamber are encompassed by a container, wherein the container is a single dose package.  
     
     
         33 . The method of  claim 29 , wherein the animal is a dog.  
     
     
         34 . The method of  claim 33 , wherein the insect infestation comprises flea and tick infestation.  
     
     
         35 . The method of  claim 33 , wherein the method comprises administering about 15 to 130 mg/kg dog body weight permethrin, about 1.5 to 20 mg/kg dog body weight dinotefuran, and about 0.15 to 2.0 mg/kg dog body weight pyriproxyfen.  
     
     
         36 . The method of  claim 33 , wherein the method comprises administering about 80 to 500 mg/kg dog body weight phenothrin, about to 1.5 to 20 mg/kg dog body weight dinotefuran, and about 0.15 to 2 mg/kg dog body weight pyriproxyfen.  
     
     
         37 . The method of  claim 33 , wherein the method comprises administering about 15 to 130 mg/kg dog body weight permethrin, about 0.5 to 20 mg/kg dog body weight acetamiprid, and about 0.15 to 2.0 mg/kg dog body weight pyriproxyfen.  
     
     
         38 . The method of  claim 33 , wherein the method comprises administering about 80 to 500 mg/kg dog body weight phenothrin, about 0.5 to 20 mg/kg dog body weight acetamiprid and about 0.15 to 2 mg/kg dog body weight pyriproxyfen.  
     
     
         39 . The method of  claim 29 , wherein the animal is a cat.  
     
     
         40 . The method of  claim 39 , wherein the method comprises administering about 100 to 1000 mg/kg cat body weight phenothrin, about to 15 to 180 mg/kg cat body weight dinotefuran, and about 2 to 18 mg/kg cat body weight pyriproxyfen.  
     
     
         41 . The method of  claim 39 , wherein the method comprises administering about 80 to 500 mg/kg cat body weight phenothrin, about 3 to 200 mg/kg cat body weight acetamiprid and about 0.15 to 2 mg/kg cat body weight pyriproxyfen.