Methods of treating cancer using C-4 carbonate taxanes

Abstract

A process for the preparation of novel C-4 carbonate taxanes useful as antitumor agents.

1 - 30 . (canceled)  
   
   
       31 . A method for treating cancer comprising administering to a patient in need thereof a therapeutically effective dose of one or more compounds of formula I  
     
       
         
         
             
             
         
       
     
     wherein: 
 R is phenyl, isopropyl, or tert butyl;  
 R 1  is —C(O)R Z  in which R Z  is (CH 3 ) 3 CO—, (CH 3 ) 3 CCH 2 —, CH 3 (CH 2 ) 3 O—, cyclobutyl-, cyclohexyloxy, or (2-furyl); and  
 R 2  is CH 3 C(O)O—,  
 or a pharmaceutically acceptable salt thereof.  
 
   
   
       32 . The method of  claim 31  wherein one or more compounds of formula I are selected from the group consisting of compounds as shown in the table  
     
       
         
               
               
               
               
             
                   
               
                   
               
                 R 
                 R 1   
                 R 2   
                 Compound 
               
                   
               
                 (CH 3 ) 3 C— 
                 (CH 3 ) 3 COC(O)— 
                 CH 3 C(O)O— 
                 Ia 
               
                 (CH 3 ) 2 CH— 
                 (CH 3 ) 3 COC(O)— 
                 CH 3 C(O)O— 
                 Ib 
               
                 Phenyl- 
                 (CH 3 ) 3 CCH 2 C(O)— 
                 CH 3 C(O)O— 
                 Ic 
               
                 Phenyl- 
                 CyclobutylC(O)— 
                 CH 3 C(O)O— 
                 Id 
               
                 (CH 3 ) 3 C— 
                 CyclohexylOC(O)— 
                 CH 3 C(O)O— 
                 Ie 
               
                 (CH 3 ) 3 C— 
                 (CH 3 ) 3 CCH 2 C(O)— 
                 CH 3 C(O)O— 
                 If 
               
                 Phenyl- 
                 (CH 3 ) 3 COC(O)— 
                 CH 3 C(O)O— 
                 Ig 
               
                 Phenyl- 
                 CH 3 (CH 2 ) 3 OC(O)— 
                 CH 3 C(O)O— 
                 Ih 
               
                 (CH 3 ) 3 C— 
                 CyclobutylC(O)— 
                 CH 3 C(O)O— 
                 Ij 
               
                 (CH 3 ) 3 C— 
                 (2-furyl)C(O)— 
                 CH 3 C(O)O— 
                 Ik 
               
                   
               
                   
               
           
              
              
              
              
             
             
              
              
              
              
              
              
              
              
              
              
              
              
             
          
         
       
     
   
   
       33 . The method of  claim 32  wherein the compound of formula I is Compound Ia.  
   
   
       34 . The method of  claim 31  wherein the cancer being treated is selected from the group consisting of cancers of the lungs, prostate, gastric, breast, liver and sarcomas.  
   
   
       35 . The method of  claim 34  wherein the lung cancer being treated is non-small cell lung cancer.  
   
   
       36 . The method of  claim 31  wherein the compound is administered orally.  
   
   
       37 . The method of  claim 33  wherein the compound is administered orally.