Electromagnetic treatment apparatus and method for angiogensis modulation of living tissues and cells

Abstract

An apparatus and method for electromagnetic treatment of living tissues and cells comprising: configuring at least one waveform according to a mathematical model having at least one waveform parameter, said at least one waveform to be coupled to a angiogenesis and neovascularization target pathway structure; choosing a value of said at least one waveform parameter so that said at least waveform is configured to be detectable in said angiogenesis and neovascularization target pathway structure above background activity in said target pathway structure; generating an electromagnetic signal from said configured at least one waveform; and coupling said electromagnetic signal to said angiogenesis and neovascularization target pathway structure using a coupling device.

1 ) A method for electromagnetic treatment of living tissues and cells by enhancing angiogenesis and neovascularization comprising the steps of: 
 Configuring at least one waveform according to a mathematical model having at least one waveform parameter, said at least one waveform to be coupled to a angiogenesis and neovascularization target pathway structure;    Choosing a value of said at least one waveform parameter so that said at least waveform is configured to be detectable in said angiogenesis and neovascularization target pathway structure above background activity in said angiogenesis and neovascularization target pathway is structure;    Generating an electromagnetic signal from said configured at least one waveform; and    Coupling said electromagnetic signal to said angiogenesis and neovascularization target pathway structure using a coupling device.    
     
     
         2 ) The method of  claim 1 , wherein said at least one waveform parameter includes at least one of a frequency component parameter that configures said at least one waveform to repeat between about 0.01 Hz and about 100 MHz, a burst amplitude envelope parameter that follows a mathematically defined amplitude function, a burst width parameter that varies at each repetition according to a mathematically defined width function, a peak induced electric field parameter varying between about 1 μV/cm and about 100 mV/cm in said target pathway structure according to a mathematically defined function, and a peak induced magnetic electric field parameter varying between about 1 μT and about 0.1 T in said target pathway structure according to a mathematically defined function.  
     
     
         3 ) The method of  claim 1 , wherein said angiogenesis and neovascularization target pathway structure includes at least one of ions and ligands.  
     
     
         4 ) The method of  claim 1 , further comprising the step of binding ions and ligands to regulatory molecules in living cells and tissues thereby modulating angiogenesis and neovascularization.  
     
     
         5 ) The method of  claim 4 , wherein said binding of ions and ligands includes modulating Calcium to Calmodulin binding.  
     
     
         6 ) The method of  claim 4 , wherein said binding of ions and ligands includes modulating growth factor production in living cells and tissues.  
     
     
         7 ) The method of  claim 4 , wherein said binding of ions and ligands, includes modulating cytokine production in living cells and tissues.  
     
     
         8 ) The method of  claim 4 , wherein said binding of ions and ligands includes modulating growth factors and cytokines relevant to angiogenesis and neovascularization.  
     
     
         9 ) The method of  claim 4 , wherein said binding of ions and ligands includes modulating angiogenesis and neovascularization for treatment of bone fractures and disorders.  
     
     
         10 ) The method of  claim 4 , wherein said binding of ions and ligands includes modulating angiogenesis and neovascularization for treatment of cardiovascular diseases.  
     
     
         11 ) The method of  claim 4 , wherein said binding of ions and ligands includes modulating angiogenesis and neovascularization for treatment of cerebral diseases.  
     
     
         12 ) The method of  claim 4 , wherein said binding of ions and ligands includes modulating angiogenesis and neovascularization for treatment of cerebrovascular disease.  
     
     
         13 ) The method of  claim 4 , wherein said binding of ions and ligands includes modulating angiogenesis and neovascularization for treatment peripheral vascular disease.  
     
     
         14 ) The method of  claim 4 , wherein said binding of ions and ligands includes modulating angiogenesis and neovascularization for treatment of diseased or ischemic cells and tissues.  
     
     
         15 ) The method of  claim 4 , wherein said binding of ions and ligands includes modulating angiogenesis and neovascularization for treatment of an acute or chronic soft tissue wound.  
     
     
         16 ) The method of  claim 4 , wherein said binding of ions and ligands includes modulating angiogenesis and neovascularization for treatment of sprains strains and contusions.  
     
     
         17 ) An electromagnetic treatment apparatus for plants, animals, and humans to enhance angiogenesis and neovascularization comprising: 
 A waveform configuration means for configuring at least one waveform to be coupled to a angiogenesis and neovascularization target pathway structure according to a mathematical model having at least one waveform parameter capable of being chosen so that said at least one waveform is configured to be detectable in said angiogenesis and neovascularization target structure above background activity in said angiogenesis and neovascularization target pathway structure;    An electromagnetic signal generating means connected to said waveform device by at least one connecting means for generating an electromagnetic signal from said configured at least one waveform; and    A coupling device connected by at least one connecting means to said electromagnetic signal generating device for coupling said electromagnetic signal to said angiogenesis and neovascularization target pathway structure.    
     
     
         18 ) The electromagnetic treatment apparatus of  claim 17 , wherein said at least one waveform parameter includes at least one of a frequency component parameter that configures said at least one waveform to repeat between about 0.01 Hz an about 100 MHz according to a mathematical function, a burst amplitude envelope parameter that follows a mathematically defined amplitude function, a burst width parameter that varies at each repetition according to a mathematically defined width function, a peak induced electric field parameter varying between about 1 μV/cm and about 100 mV/cm in said angiogenesis and neovascularization target pathway structure according to a mathematically defined function, and a peak induced magnetic electric field parameter varying between about 1 μT and about 0.1 T in said angiogenesis and neovascularization target pathway structure according to a mathematically defined function.  
     
     
         19 ) The electromagnetic signal generating means of  claim 17  wherein the signal is inductively coupled to living cells and tissues wherein Calcium binding to Calmodulin is modulated.  
     
     
         20  ) The electromagnetic signal generating means of  claim 17  wherein the signal is capacitively coupled to living cells and tissues wherein Calcium binding to Calmodulin is modulated.  
     
     
         21 ) The electromagnetic signal generating means of  claim 17  wherein the signal is inductively coupled to living cells and tissues wherein growth factors and cytokines relevant to angiogenesis and neovascularization are modulated.  
     
     
         22 ) The electromagnetic signal generating means of  claim 21  wherein the growth factors include at least one of fibroblast growth factors, platelet derived growth factors and interleukin growth factors.  
     
     
         23 ) The electromagnetic signal generating means of  claim 17  wherein the signal is capacitively coupled to living cells and tissues wherein growth factors and cytokines relevant to angiogenesis and neovascularization are modulated.  
     
     
         24 ) The electromagnetic signal generating means of  claim 23  wherein the growth factors include at least one of fibroblast growth factors, platelet derived growth factors and interleukin growth factors.  
     
     
         25 ) The electromagnetic signal generating means of  claim 17  wherein the signal is inductively coupled to living cells and tissues to modulate growth factor production.  
     
     
         26 ) The electromagnetic signal generating means of  claim 17  wherein the signal is capacitively coupled to living cells and tissues to modulate growth factor production.  
     
     
         27 ) The electromagnetic signal generating means of  claim 17  wherein the signal is inductively coupled to living cells and tissues to modulate cytokine production.  
     
     
         28 ) The electromagnetic signal generating means of  claim 17  wherein the signal is capacitively coupled to living cells and tissues to modulate cytokine production.  
     
     
         29 ) The electromagnetic signal generating means of  claim 17  wherein the signal is inductively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of bone fractures and disorders.  
     
     
         30 ) The electromagnetic signal generating means of  claim 17  wherein the signal is capacitively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of bone fractures and disorders.  
     
     
         31 ) The electromagnetic signal generating means of  claim 17  wherein the signal is inductively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of cardiovascular diseases.  
     
     
         32 ) The electromagnetic signal generating means of  claim 17  wherein the signal is capacitively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of cardiovascular diseases.  
     
     
         33 ) The electromagnetic signal generating means of  claim 17  wherein the signal is inductively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of cerebral diseases.  
     
     
         34 ) The electromagnetic signal generating means of  claim 17  wherein the signal is capacitively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of cerebral diseases.  
     
     
         35 ) The electromagnetic signal generating means of  claim 17  wherein the signal is inductively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of cerebrovascular disease.  
     
     
         36 ) The electromagnetic signal generating means of  claim 17  wherein the signal is capacitively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of cerebrovascular disease.  
     
     
         37 ) The electromagnetic signal generating means of  claim 17  wherein the signal is inductively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of peripheral vascular disease.  
     
     
         38 ) The electromagnetic signal generating means of  claim 17  wherein the signal is capacitively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of peripheral vascular disease.  
     
     
         39 ) The electromagnetic signal generating means of  claim 17  wherein the signal is inductively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of diseased or ischemic cells and tissues.  
     
     
         40 ) The electromagnetic signal generating means of  claim 17  wherein the signal is capacitively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of diseased or ischemic cells and tissues.  
     
     
         41 ) The electromagnetic signal generating means of  claim 17  wherein the signal is inductively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of an acute or chronic soft tissue wound.  
     
     
         42 ) The electromagnetic signal generating means of  claim 17  wherein the signal is capacitively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of an acute or chronic soft tissue wound.  
     
     
         43 ) The electromagnetic signal generating means of  claim 17  wherein the signal is inductively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of sprains strains and contusions.  
     
     
         44 ) The electromagnetic signal generating means of  claim 17  wherein the signal is capacitively coupled to living cells and tissues to modulate angiogenesis and neovascularization for the treatment of sprains strains and contusions.