Topical composition for acne treatment

Abstract

A topical composition for treatment of skin disorders such as acne is disclosed. The composition includes benzoyl peroxide in an amount from between 0.5 and 20% by weight. There is also provided a water miscible solvent for solubilizing the benzoyl peroxide in an amount from between 10% and 95% by weight and finally, a water miscible or water dispersible surfactant is present in an amount from between 0.5 and 95% by weight.

1 . A topical composition for treatment of skin disorders, comprising: 
 benzoyl peroxide in an amount from between 0.5 and 20% by weight;    a water miscible solvent for solubilizing said benzoyl peroxide in an amount from between 10% and 95% by weight; and    a water miscible or water dispersible surfactant in an amount from between 0.5% and 95% by weight.    
   
   
       2 . The composition of  claim 1 , wherein said water miscible solvent is selected from the group consisting of aliphatic alcohols, propylene glycol, butylene glycol, polyethylene glycols, ethoxydiglycol, isosorbide ethers—dimethylisosorbide, diethylisosorbide, methylethylisosorbide, propylene carbonate, acetamide, solketal, dimethylformamide, ethyllactate and N-methylpyrrolidone.  
   
   
       3 . The composition of  claim 1 , wherein said water miscible or water dispersible surfactant is selected from the group consisting of dermatologically acceptable polyethoxylated aliphatic or aromatic derivatives, polyglycerin derivatives, sugar and polyol esters or ethers with HLB in the range of between 3 and 24.  
   
   
       4 . The composition of  claim 1 , wherein said benzoyl peroxide is solubilized in said solvent.  
   
   
       5 . The composition of  claim 1 , further including a thickener in amount from between 0.5% and 50% by weight.  
   
   
       6 . The composition of  claim 5 , wherein said thickener prevents precipitation of benzoyl peroxide during storage.  
   
   
       7 . The composition of  claim 5 , wherein said thickener is a dermatologically acceptable material with melting point of not less than 25° C.  
   
   
       8 . The composition of  claim 1 , further including a moisture absorbing additive in amount from between 0.5 and 50% by weight.  
   
   
       9 . The composition of  claim 8 , wherein said moisture absorbing additive is insoluble in water and in components of said topical composition.  
   
   
       10 . The composition of  claim 8 , wherein said moisture absorbing additive selected from the group consisting of inorganic silicates, phosphates, carbonates, alumosilicates, ceolites; cross-linked polymers, polyvinylpyrrolidone PVP-XL, polysaccharides, powdered cellulose, cellulose fibres or microcrystalline cellulose, starch and starch derivatives, polyacrylates and fibrous materials.  
   
   
       11 . The composition of  claim 1 , wherein said water miscible solvent is dimethylisosorbide, ethoxydiglycol, or mixture thereof in ratio from between 1:10 and 10:1.  
   
   
       12 . The composition of  claim 1 , wherein said skin disorder is a viral infection.  
   
   
       13 . The composition of  claim 1 , wherein said skin disorder is a microbial infection.  
   
   
       14 . The composition of  claim 1 , wherein said skin disorder is a fungal infection.  
   
   
       15 . A treatment method for a person afflicted with acne or superficial fungal infection, comprising applying to an affected area of the person's skin, a therapeutically effective amount of a composition comprising: 
 benzoyl peroxide in an amount from between 0.5 and 20% by weight;    a water miscible solvent for solubilizing said benzoyl peroxide in an amount from between 10% and 95% by weight;    a water miscible or water dispersible surfactant in an amount from between 0.5% and 95% by weight;    dermatologically acceptable thickener with a melting point no less than 25° C.; and    a dermatologically acceptable moisture absorbing additive in amount from between 0.5% and 50% by weight.    
   
   
       16 . The method of  claim 12 , wherein said water miscible solvent is dimethylisosorbide, ethoxydiglycol, or a mixture thereof in a ratio from between 1:10 and 10:1.  
   
   
       17 . A method for improving skin penetration of benzoyl peroxide in topical composition comprising: 
 providing benzoyl peroxide in an amount between 0.5 and 20% by weight;    a water miscible solvent for solubilizing said benzoyl peroxide in an amount from between 10% and 95% by weight;    a water miscible or water dispersible surfactant in an amount from between 0.5% and 95% by weight; and    mixing to form a liquid or semi-solid composition where said benzoyl peroxide is solubilized in said solvent.