US2005256044A1PendingUtilityA1

Gastrointestinal proliferative factor and uses thereof

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Individually held — no corporate assignee on recordPriority: Jan 27, 2004Filed: Jan 27, 2005Published: Nov 17, 2005
Est. expiryJan 27, 2024(expired)· nominal 20-yr term from priority
Inventors:Bryan BoyleWalter FunkMakoto KakitaniTakeshi OshimaEun Ju ParkY. TangMikio YagiKazuma Tomizuka
A61P 43/00A61P 29/00A01K 2267/01A61K 48/005A61P 1/00C07K 14/475G01N 33/5088C12N 2799/022A01K 2227/105A01K 2217/072A01K 67/0275C12N 15/8509A61K 38/1709C12N 2800/30A61K 38/18A61K 38/17
54
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Claims

Abstract

The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor (GIPF) polynucleotides and polypeptides. The invention further relates to the therapeutic use of GIPF to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.

Claims

exact text as granted — not AI-modified
1 . A pharmaceutical composition comprising a polypeptide comprising a biologically active fragment of GIPF and a pharmaceutically acceptable carrier.  
     
     
         2 . The pharmaceutical composition of  claim 1  wherein the GIPF is human GIPF.  
     
     
         3 . The pharmaceutical composition of  claim 1  wherein polypeptide comprises a biologically active fragment of the polypeptide of SEQ ID NO:4.  
     
     
         4 . A method of stimulating epithelial cell proliferation in a subject comprising administering to the subject a composition comprising a GIPF polypeptide, fragment or analog thereof and a carrier.  
     
     
         5 . The method for stimulating epithelial cell proliferation in the gastrointestinal tract of a patient, the method comprising administering a therapeutically effective amount of a composition comprising a GIPF polypeptide and a pharmaceutically acceptable carrier.  
     
     
         6 . The method of  claim 5  wherein epithelial cell proliferation in the esophagus is stimulated.  
     
     
         7 . The method of  claim 5  wherein epithelial cell proliferation in the small intestine is stimulated.  
     
     
         8 . The method of  claim 5  wherein epithelial cell proliferation in the large intestine is stimulated.  
     
     
         9 . The method of  claim 5  wherein epithelial cell proliferation in the stomach is stimulated.

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