Method for preparing free flow resin

Abstract

The present invention provides a method for producing a free flowing and/or non clumping resin that includes prior to drying, shrinking the resin under agitation. In one variant of the invention, the is a resin used in solid phase synthesis of peptides. In another aspect the invention provides a process of making a peptide using the free flowing resin described herein, and a polypeptide made using the process. Various therapeutics are then be made using the polypepdite.

1 - 5 . (canceled)  
   
   
       6 . A process of making a polypeptide using the resin of claim  1 .  
   
   
       7 - 8 . (canceled)  
   
   
       9 . A resin product made using a method comprising 
 i) providing a resin dispersed in a swelling solvent in a vessel,    ii) while said resin is under agitation, adding a non-swelling solvent to said resin, and    iii) then drying said resin,    wherein said resin comprises a crosslinked polymer that is polymerized from monomers comprising    a) one or more monounsaturated vinylaromatic monomers, and    b) one or more monomers having 2 or more copolymerizable carbon-carbon double bonds per molecule.    
   
   
       10 - 12 . (canceled)  
   
   
       13 . The resin product of  claim 9 , wherein said crosslinked polymer is polymerized from monomers comprising at least 50 weight percent, based on the total monomer weight, styrene.  
   
   
       14 . The resin product of  claim 9 , wherein said crosslinked polymer is polymerized from monomers comprising from 0.5 to 3.0 mole percent, based on the total of all monomers, one or more monomers having 2 or more copolymerizable carbon-carbon double bonds per molecule.  
   
   
       15 . The resin product of  claim 9 , wherein said resin product is a solid phase synthesis resin.  
   
   
       16 . The resin product of  claim 9 , wherein said adding a non-swelling solvent causes said resin to shrink.  
   
   
       17 . The resin product of  claim 9 , wherein said vessel comprises a filter.  
   
   
       18 . The resin product of  claim 9 , wherein said agitation is selected from the group consisting of mechanical mixing, tumbling, countercurrent charging, providing kinetic energy to said resin, lifting said resin from a resin bed, fluidizing said resin, expanding a resin bed, and charging solvent in from a bottom of a resin bed into said resin.