US2005261508A1PendingUtilityA1
Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE), pharmaceutical methods and compositions employing such inhibitors, and processes for evaluating the NHE-inhibitory efficacy of compounds
Est. expiryJun 7, 2015(expired)· nominal 20-yr term from priority
C07J 9/00G01N 33/5061G01N 2500/00G01N 33/5011G01N 33/5091G01N 33/5008G01N 33/5088G01N 33/505C07J 41/0005G01N 33/5044A61K 31/56G01N 33/5064
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Abstract
Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
Claims
exact text as granted — not AI-modified1 . A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
2 . A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
3 . A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.Cited by (0)
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