Method and pharmaceutical to treat spinal discs

Abstract

An injectable for injection into a spinal disc, and a method to treat a spinal disc with the injectable. The injectable consists essentially of chondroitin sulfate and glucosamine HCl buffered to a pH above about 6.0.

1 . For injection directly into a disrupted spinal disc to reduce pain caused by the disrupted disc, an injectable consisting essentially of: 
 (a) a stock solution consisting by weight percentages, chondroitin sulfate, between about 0.5% to about 2.0% glucosamine HCl, between about 5.0% to about 20.0%, and sterile water to make 100%, and buffer substance in quantity sufficient to bring the pH of this injectable to a value above 6.0; and    (b) water to dilute said stock solution to a concentration tolerated by the disc.    
   
   
       2 . An injectable according to  claim 1  in which said stock solution further includes a solution of dextrose (about 50% by weight of its own solution) in the ratio between about 1:1 to about 3:2 by weight (dextrose: stock solution before adding dextrose solution).  
   
   
       3 . An injectable according to  claim 1  in which said stock solution further includes a temporary anesthetic.  
   
   
       4 . An injectable according to  claim 1  in which said stock solution further includes low viscosity sodium carboxymethylcellulose in concentration between about 0.5% to about 2.0%  
   
   
       5 . An injectable according to  claim 1  in which the concentration of chondroitin sulfate in the stock solution is between about 1.5%, and the concentration of glucosamine HCl about 8%.  
   
   
       6 . An injectable according to  claim 1  in which the ration of glucosamine to chondroitin is between about 3:1 to 10:1.  
   
   
       7 . For injection directly into a disrupted spinal disc to reduce pain caused by the disrupted disc, a stock solution consisting essentially of: glucosamine HCl, about 8%, chondroitin sulfate about 1.5%, phosphate buffer substances to above pH 6.0, sterile water to make 100%; and 
 sterile water or normal saline solution to dilute the stock solution about by half.    
   
   
       8 . An injectable according to  claim 7  in which said stock solution for this includes low viscosity sodiumcarboxymethylcellulose, about 1.0%, and a temporary anaesthetic, about 1%.  
   
   
       9 . An injectable according to  claim 8  in which said stock solution further includes a volume of 50% dextrose, about ½ of the volume of the stock solution of  claim 7 .  
   
   
       10 . An injectable according to  claim 9  in which said stock solution further includes a volume of contrast material and antibiotic about ½ of the volume of the stock solution of  claim 7 .  
   
   
       11 . The method of treating a disrupted spinal disc comprising injecting a physiologically acceptably amount of said injectable of  claim 1  into said disc.  
   
   
       12 . The method of treating a disrupted spinal disc comprising injecting the injectable of  claim 7  into said disc.  
   
   
       13 . The method of treating a disrupted spinal disc comprising injecting the injectable of  claim 10  into said disc.