Substituted pyrimidines as selective cyclooxygenase-2 inhibitors

Abstract

Methods for the treatment of pain, fever, inflammation of a variety of conditions and diseases.

1 - 15 . (canceled)  
   
   
       16 . A method of treating a subject suffering from a condition selected from the group consisting of pain, fever, and inflammation, which method comprises administering to said subject an effective COX-2 inhibiting amount of a compound of formula (I)  
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable salt or solvate thereof, in which: 
 R 1  is H or C 1-6 alkyl;  
 R 2  is  
                     
  wherein   defines the point of attachment of the ring; and  
 R 3  is C 1-6 alkyl or NH 2 .  
 
   
   
       17 . A method of treating a subject suffering from a condition selected from the group consisting of rheumatic fever, symptoms associated with influenza or other viral infections, lower back pain, neck pain, headache, toothache, sprains, strains, myositis, neuropathic pain, synovitis, arthritis, rheumatoid arthritis, degenerative joint diseases, osteoarthritis, gout, ankylosing spondylitis, tendinitis, bursitis, psoriasis, eczema, burns, dermatitis, sports injuries, injuries arising from surgical and dental procedures, colonic cancer, stroke, epilepsy, epileptic seizures, dysmenorrhoea, premature labor, liver disease, asthma, allergic rhinitis, respiratory distress syndrome, inflammatory bowel disease, Crohns disease, gastritis, irritable bowel syndrome, ulcerative colitis, inflammation in vascular disease, inflammation in migraine, inflammation in periarteritis, inflammation in nodosa, inflammation in thyroiditis, inflammation in aplastic anemia, inflammation in Hodgkin's disease, inflammation in sclerodoma, inflammation in type I diabetes, inflammation in myasthenia gravis, inflammation in multiple sclerosis, inflammation in sorcoidosis, inflammation in nephrotic syndrome, inflammation in Bechet's syndrome, inflammation in polymyositis, inflammation in gingivitis, inflammation in conjunctivitis, inflammation in myocardial ischemia, retinitis, retinopathies, uveitis, acute injury to the eye tissue, dementia, degenerative dementia, vascular dementia, dementia associated with intracranial space occupying lesions, dementia associated with trauma, dementia associated with infections, dementia associated with metabolism, dementia associated with toxins, dementia associated with anoxia, dementia associated with vitamin deficiency, mild cognitive impairment associated with aging, ileus, gastroesophageal reflux disease, gastroparesis, non-ulcerative dyspepsia and non-cardiac chest pain, which method comprises administering to said subject an effective COX-2 inhibiting amount of a compound of formula (I)  
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable salt or solvate thereof, in which: 
 R 1  is H or C 1-6 alkyl;  
 R 2  is  
                     
  defines the point of attachment of the ring; and  
 R 3  is C 1-6 alkyl or NH 2 .  
 
   
   
       18 . A method of treating a subject suffering from an inflammatory disorder, which method comprises administering to said subject an effective COX-2 inhibiting amount of a compound of formula (I)  
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable salt or solvate thereof, in which: 
 R 1  is H or C 1-6 alkyl;  
 R 2  is  
                     
  defines the point of attachment of the ring; and  
 R 3  is C 1-6 alkyl or NH 2 .