Preventive and therapeutic medicament for gastroesophageal reflux disease

Abstract

The compound of the following formula: wherein R 1 and R 2 independently represent a hydrogen atom or a lower alkyl group; A represents a group selected from the group consisting of 1-azabicyclo[3.2.2]nonyl group, 1-azabicyclo[2.2.2]octyl group, or an N-oxide thereof, or a pharmaceutically acceptable salt thereof or a hydrate thereof has both improving effect on enterokinetic functions and suppressing effect on acid secretion, and also is highly safe. Accordingly, the substance is useful as preventive or therapeutic medicament for a gastroesophageal reflux disease.

1 . A preventive or therapeutic medicament for a gastroesophageal reflux disease, which comprises as an active ingredient a thieno[3,2-b]pyridinecarboxamide derivative represented by the following formula (i) or a pharmaceutically acceptable salt thereof, or a hydrate thereof:  
     
       
         
         
             
             
         
       
     
     wherein R 1  and R 2  independently represent a hydrogen atom or a lower alkyl group; A represents a group selected from the group consisting of 1-azabicyclo[3.2.2]nonyl group, 1-azabicyclo[2.2.2]octyl group, or an N-oxide thereof.  
   
   
       2 . The preventive or therapeutic medicament according to  claim 1 , wherein R 1  and R 2  independently represent a hydrogen atom or methyl group, and A is 1-azabicyclo[2.2.2]oct-3-yl group or an N-oxide thereof.  
   
   
       3 . The preventive or therapeutic medicament according to  claim 1 , wherein said derivative is any one of N-(1-azabicyclo[2.2.2]oct-3-yl)-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide, (R)-N-(1-azabicyclo[2.2.2]oct-3-yl)-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide, or (S)-N-(1-azabicyclo[2.2.2]oct-3-yl)-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide.  
   
   
       4 . The preventive or therapeutic medicament according to  claim 1 , wherein said derivative is (R)-N-(1-azabicyclo[2.2.2]oct-3-yl)-7-oxo-4,7-dihydrothieno-[3,2-b]pyridine-6-carboxamide hydrochloride.  
   
   
       5 . The preventive or therapeutic medicament according to  claim 1 , wherein the gastroesophageal reflux disease is reflux esophagitis or non-ulcer dyspepsia.