Platinum complexes and methods for inhibiting tumor cell proliferation

Abstract

The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.

1 . A platinum complex having the structure of a complex selected from the group consisting of the complex designated herein as CPA-2, CPA-4, CPA-5, CPA-6, CPA-8, CPA-9, CPA-10, CPA-11, CPA-12, CPA-13, CPA-14, CPA-15, CPA-16, CPA-17, CPA-18, CPA-19, CPA-20, CPA-21, CPA-22, CPA-23, CPA-24, CPA-25, CPA-26, CPA-27, CPA-28, CPA-29, CPA-30, CPA-31, CPA-32, CPA-33, CPA-34, CPA-35, CPA-36, CPA-37, CPA-38, CPA-39, CPA-40, CPA-41, CPA-42, CPA-43, CPA-44, CPA-45, CPA-46, CPA-47, CPA-48, CPA-49, CPA-50, CPA-51, CPA-52, CPA-53, CPA-54, CPA-55, CPA-56, CPA-57, CPA-58, JP3, JP4, JP5, JP6, GD6, GD2, GD3, GD4, JP13A, JP14C, JP14D, JP15, or a pharmaceutically acceptable salt thereof.  
     
     
         2 . A method for treating or preventing an oncological disorder, an inflammatory disorder, or a viral, bacterial, or parasitic infection in a patient, said method comprising administering an effective amount of a platinum complex of  claim 1  to the patient.