US2006002987A1PendingUtilityA1

Dissolvable film composition

38
Individually held — no corporate assignee on recordPriority: Jun 22, 2004Filed: Jun 21, 2005Published: Jan 5, 2006
Est. expiryJun 22, 2024(expired)· nominal 20-yr term from priority
Inventors:Andrew J. BevacquaPeter J. LentiniTracy N. KeelerJulles ZecchinoPauline Vassiliou
A61P 17/00A61Q 19/08A61Q 19/02A61K 9/7007A61K 8/9728A61K 2800/882A61Q 17/04A61K 8/8176A61K 8/9711A61K 8/9789A61K 8/39A61K 8/35A61K 8/9794A61K 8/0216A61K 8/8129A61K 8/345A61K 9/0014A61K 8/731A61K 8/97A61K 8/9761
38
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Claims

Abstract

A system, a kit and methods for delivering an effective amount of a labile active to the skin, comprising a composition comprising an effective amount of a labile active agent incorporated into a water-soluble polymeric film and an additive composition capable of dissolving the water-soluble polymeric film.

Claims

exact text as granted — not AI-modified
1 . A system for delivering a labile active to the skin, comprising: 
 a composition comprising an effective amount of a labile active agent incorporated into at least one water-soluble polymeric film; and    an additive composition capable of dissolving the water-soluble polymeric film.    
     
     
         2 . The system of  claim 1  wherein the labile active is selected from the group consisting of antioxidants, antiaging agents, whitening agents, UV-protective agents, skin conditioning agents, or combinations thereof.  
     
     
         3 . The system of  claim 2  wherein the labile active is selected from the group consisting of green tea extracts, white tea extracts, red tea extracts, black tea extracts, licorice extracts, phytosphingosine, ethylbisiminomethylguaiacol manganese chloride, white birch extract, hinokitiol, coffee extract, hoelen mushroom extract, ascorbic acid, siegesbeckia, rosemary extract, silymarin,  Boswellia  extract, ubiquinone, retinol, resveratrol, potassium cholesterol sulfate, protease enzymes, lipase enzymes, apigenin, vitamin E, grape seed extract, lutein, licochalcone, luteolin, ursolic acid,  Centella asiatica  extract, ximenynic acid, ferulic acid, amentoflavone, dihydroxyacetone, conjugated linoleate, salicylic acid, 1,3-Beta Glucan, and triclosan, and combinations thereof.  
     
     
         4 . The system of  claim 1  wherein the labile active is hinokitiol.  
     
     
         5 . The system of  claim 1  wherein the labile active is a polyphenol.  
     
     
         6 . The system of  claim 5  wherein the polyphenol is a green tea extract.  
     
     
         7 . The system of  claim 1  wherein the composition comprises at least two polymeric films.  
     
     
         8 . The system of  claim 7  wherein at least one film is skin-adhesive.  
     
     
         9 . The system of  claim 8  wherein the labile active is incorporated into the skin-adhesive film.  
     
     
         10 . The system of  claim 9  wherein a second polymeric film is adjacently adhered to the skin-adhesive film.  
     
     
         11 . The system of  claim 1  wherein the polymeric film contains no more than between 0.1% to 2% water.  
     
     
         12 . The system of  claim 1  wherein the water-soluble polymeric film is selected from the group consisting of collagen derivatives, cellulose derivatives, pullulan, homo- and copolymers of vinyl pyrrolidone, homo- or copolymers of vinyl alcohol, homo- and copolymers of acrylic and methacrylic acids, and salts and esters thereof, starch derivatives, gums, alginates, vegetable proteins, hellac, crotonic acid polymers, adipic acid polymers, carageenans, and mixtures thereof.  
     
     
         13 . The system of  claim 1  wherein the additive composition comprises an active selected from the group consisting of peptides, famesol, bisabolol, phytantriol, glycerol, urea, guanidine , vitamins and derivatives thereof, sunscreens, resorcinol, salicylic acid, phytosterols, lipoic acid, flavonoids, aloe vera extract, allantoin and combinations thereof.  
     
     
         14 . A kit for delivering a labile active to the skin, comprising a unit package containing the system of  claim 1 .  
     
     
         15 . The kit of  claim 14  wherein the labile active is selected from the group consisting of an effective amount of antioxidants, antiaging agents, whitening agents, UV-protective agents, skin conditioning agents, or combinations thereof.  
     
     
         16 . The kit of  claim 14  wherein the labile active is selected from the group consisting of an effective amount of green tea extracts, white tea extracts, red tea extracts, black tea extracts, licorice extracts, phytosphingosine, ethylbisiminomethylguaiacol manganese chloride, white birch extract, hinokitiol, coffee extract, hoelen mushroom extract, ascorbic acid, siegesbeckia, rosemary extract, silymarin,  Boswellia  extract, ubiquinone, retinol, resveratrol, potassium cholesterol sulfate, protease enzymes, lipase enzymes, apigenin, vitamin E, grape seed extract, lutein, licochalcone, luteolin, ursolic acid,  Centella asiatica  extract, ximenynic acid, ferulic acid, amentoflavone, dihydroxyacetone, conjugated linoleate, salicylic acid, 1,3-Beta Glucan, and triclosan, and combinations thereof.  
     
     
         17 . The kit of  claim 14  wherein the labile active is hinokitiol.  
     
     
         18 . The system of  claim 14  wherein the labile active is a polyphenol.  
     
     
         19 . The system of  claim 18  wherein the polyphenol is a green tea extract.  
     
     
         20 . The kit of  claim 14  wherein the composition comprises at least two polymeric films.  
     
     
         21 . The kit of  claim 20  wherein at least one film is skin-adhesive.  
     
     
         22 . The kit of  claim 21  wherein the labile active is incorporated into the skin-adhesive film.  
     
     
         23 . The kit of  claim 21  wherein a second polymeric film is adjacently adhered to the skin-adhesive film.  
     
     
         24 . The kit of  claim 14  wherein the polymeric film contains no more than between 0.1% to 2% water.  
     
     
         25 . The kit of  claim 14  wherein the water-soluble polymeric film is selected from the group consisting of collagen derivatives, cellulose derivatives, pullulan, homo- and copolymers of vinyl pyrrolidone, homo- or copolymers of vinyl alcohol, homo- and copolymers of acrylic and methacrylic acids, and salts and esters thereof, starch derivatives, gums, alginates, vegetable proteins, hellac, crotonic acid polymers, adipic acid polymers, carageenans, and mixtures thereof.  
     
     
         26 . The kit of  claim 14  wherein the additive composition comprises an active selected from the group consisting of peptides, farnesol, bisabolol, phytantriol, glycerol, urea, guanidine, vitamins and derivatives thereof, sunscreens, resorcinol, salicylic acid, phytosterols, lipoic acid, flavonoids, aloe vera extract, allantoin and combinations thereof.  
     
     
         27 . A method of stabilizing a labile active agent which comprises incorporating the labile active agent into a composition comprising a water-soluble polymeric film and drying the composition to form a film.  
     
     
         28 . The method of  claim 27  wherein the water-soluble polymeric film is selected from the group consisting of collagen derivatives, cellulose derivatives, pullulan, homo- and copolymers of vinyl pyrrolidone, homo- or copolymers of vinyl alcohol, homo- and copolymers of acrylic and methacrylic acids, and salts and esters thereof, starch derivatives, gums, alginates, vegetable proteins, hellac, crotonic acid polymers, adipic acid polymers, carageenans, and mixtures thereof.  
     
     
         29 . The method of  claim 27  wherein the labile active is selected from the group consisting of antioxidants, antiaging agents, whitening agents, UV-protective agents, skin conditioning agents, or combinations thereof.  
     
     
         30 . The method of  claim 27  wherein the labile active is selected from the group consisting of green tea extracts, white tea extracts, red tea extracts, black tea extracts, licorice extracts, phytosphingosine, ethylbisiminomethylguaiacol manganese chloride, white birch extract, hinokitiol, coffee extract, hoelen mushroom extract, ascorbic acid, siegesbeckia, rosemary extract, silymarin,  Boswellia  extract, ubiquinone, retinol, resveratrol, potassium cholesterol sulfate, protease enzymes, lipase enzymes, apigenin, vitamin E, grape seed extract, lutein, licochalcone, luteolin, ursolic acid,  Centella asiatica  extract, ximenynic acid, ferulic acid, amentoflavone, dihydroxyacetone, conjugated linoleate, salicylic acid, 1,3-Beta Glucan, and triclosan, and combinations thereof.  
     
     
         31 . The method of  claim 27  wherein the labile active is hinokitiol.  
     
     
         32 . The system of  claim 27  wherein the labile active is a polyphenol.  
     
     
         33 . The system of  claim 32  wherein the polyphenol is a green tea extract.  
     
     
         34 . The method of  claim 27  wherein the composition comprises at least two polymeric films.  
     
     
         35 . The method of  claim 34  wherein at least one film skin-adhesive.  
     
     
         36 . The method of  claim 35  wherein the labile active is incorporated into the skin-adhesive film.  
     
     
         37 . The method of  claim 36  wherein the second polymeric film is adjacently adhered to the skin-adhesive film.  
     
     
         38 . The method of  claim 27  wherein the polymeric film contains no more than between 0.1% to 2% water.  
     
     
         39 . The method of  claim 27  further comprising a step of applying an additive composition capable of dissolving the film-forming agent.  
     
     
         40 . A method of delivering a labile active to skin comprising applying to the skin a first composition comprising at least one water-soluble polymeric film containing an effective amount of a labile skin care active and applying to the film a second composition capable of dissolving the film.  
     
     
         41 . The method of  claim 40  wherein the water-soluble polymeric film is a water-soluble agent selected from the group consisting of collagen derivatives, cellulose derivatives, pullulan, homo- and copolymers of vinyl pyrrolidone, homo- or copolymers of vinyl alcohol, homo- and copolymers of acrylic and methacrylic acids, and salts and esters thereof, starch derivatives, gums, alginates, vegetable proteins, hellac, crotonic acid polymers, adipic acid polymers, carageenans, and mixtures thereof.  
     
     
         42 . The method of  claim 40  wherein the labile active is selected from the group consisting of antioxidants, antiaging agents, whitening agents, UV-protective agents, skin conditioning agents, or combinations thereof.  
     
     
         43 . The method of  claim 40  wherein the labile active is selected from the group consisting of green tea extracts, white tea extracts, red tea extracts, black tea extracts, licorice extracts, phytosphingosine, ethylbisiminomethylguaiacol manganese chloride, white birch extract, hinokitiol, coffee extract, hoelen mushroom extract, ascorbic acid, siegesbeckia, rosemary extract, silymarin,  Boswellia  extract, ubiquinone, retinol, resveratrol, potassium cholesterol sulfate, protease enzymes, lipase enzymes, apigenin, vitamin E, grape seed extract, lutein, licochalcone, luteolin, ursolic acid,  Centella asiatica  extract, ximenynic acid, ferulic acid, amentoflavone, dihydroxyacetone, conjugated linoleate, salicylic acid, 1,3-Beta Glucan, and triclosan, and combinations thereof.  
     
     
         44 . The method of  claim 43  wherein the labile active is hinokitiol.  
     
     
         45 . The system of  claim 40  wherein the labile active is a polyphenol.  
     
     
         46 . The system of  claim 45  wherein the polyphenol is a green tea extract.  
     
     
         47 . The method of  claim 40  wherein the first composition comprises at least two polymeric films.  
     
     
         48 . The method of  claim 45  wherein at least one film is skin-adhesive.  
     
     
         49 . The method of  claim 48  wherein the labile active is incorporated into the skin-adhesive film.  
     
     
         50 . The method of  claim 40  wherein the second polymeric film is adjacently adhered to the skin-adhesive film.  
     
     
         51 . The method of  claim 40  wherein the polymeric film contains no more than between 0.1% to 2% water.

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