Local nasal immunotherapy with allergen strip for allergic rhinitis

Abstract

A method and strip for treating allergen-induced airway inflammation. The method includes applying a nasal or skin strip containing a mixture of an allergen and a pharmaceutically acceptable carrier to an individual having allergen-induced airway inflammation in a manner consistent with local nasal immunotherapy.

1 . A nasal strip for treating allergen-induced airway inflammation in an individual, comprising a substrate with a mixture of an allergen and a pharmaceutically acceptable carrier thereon for local nasal immunotherapy.  
     
     
         2 . The strip as claimed in  claim 1 , wherein the allergen-induced airway inflammation comprises allergic rhinitis, allergic conjunctivitis, allergic bronchial asthma.  
     
     
         3 . The strip as claimed in  claim 1 , wherein the substrate is nitrocellulose (NC), polyvinylidene fluoride (PVDF), nylon, filter papers, fabric, cloth, polyethylene, polypropylene, composite fibers, flexible medical grade materials, or a combination thereof.  
     
     
         4 . The strip as claimed in  claim 1 , wherein the allergen comprises dust mite extract, pollen extract, mold extract, animal dander, cockroach extract, food allergen, recombinant allergen peptide, or a combination thereof.  
     
     
         5 . The strip as claimed in  claim 1 , wherein the nasal or skin strip further comprises an immunomodulatory adjuvant.  
     
     
         6 . The method as claimed in  claim 5 , Wherein the immunomodulatory adjuvant comprises fungal immunomodulatory protein (FIP) isolated from  Flammalina velutipes,  immunostimulatory sequence CpG (CpG oligodeoxynucleotides), or mycobacterium-Bacillus Calmette Guerin (BCG).  
     
     
         7 . The strip as claimed in  claim 1 , wherein the pharmaceutically acceptable carrier is detergent, lipid solvent, glycerol, PBS, normal saline, water, petrolatum, or vaseline.  
     
     
         8 . The strip as claimed in  claim 7 , wherein the lipid solvent is alcohol or mint.  
     
     
         9 . The strip as claimed in  claim 4 , wherein the allergen is in a concentration of 1˜1000 μg/ml.  
     
     
         10 . The strip as claimed in  claim 9 , wherein the allergen is in a concentration of 1˜10 μg/ml.