US2006009099A1PendingUtilityA1

Adhesive-containing wound closure device and method

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Assignee: CLOSURE MEDICAL CORPPriority: Jul 12, 2004Filed: Jul 12, 2004Published: Jan 12, 2006
Est. expiryJul 12, 2024(expired)· nominal 20-yr term from priority
Inventors:Jerry JonnJulian QuinteroGlenn HoskinSusan Roweton
A61L 15/24A61L 15/425Y10T442/183Y10T442/172A61L 15/58Y10T442/10Y10T442/20A61L 15/44
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Claims

Abstract

An article, such as a tissue bonding article, includes a flexible material, a polymerization initiator or rate modifier disposed in or on the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material, where the polymerization initiator or rate modifier is a polymerization initiator or rate modifier for the polymerizable adhesive composition.

Claims

exact text as granted — not AI-modified
1 . A composite article, comprising: 
 a flexible material;    a polymerization initiator or rate modifier disposed in or on said flexible material; and    a polymerizable adhesive composition permeated throughout at least a portion of said flexible material,    wherein said polymerization initiator or rate modifier is a polymerization initiator or rate modifier for said polymerizable adhesive composition.    
     
     
         2 . The article of  claim 1 , wherein said flexible material is a mesh.  
     
     
         3 . The article of  claim 1 , wherein said flexible material is flexible and porous.  
     
     
         4 . The article of  claim 1 , wherein said flexible material is substantially free of elastin.  
     
     
         5 . The article of  claim 1 , wherein said flexible material is elastic.  
     
     
         6 . The article of  claim 1 , further comprising a pressure sensitive adhesive located on at least a portion of said flexible material.  
     
     
         7 . The article of  claim 1 , wherein said polymerizable adhesive composition is a monomeric composition.  
     
     
         8 . The article of  claim 1 , wherein said polymerizable adhesive composition is polymerized.  
     
     
         9 . The article of  claim 1 , wherein said polymerizable adhesive composition comprises a 1,1-disubstituted monomer.  
     
     
         10 . The article of  claim 1 , wherein said polymerizable adhesive composition comprises a cyanoacrylate monomer.  
     
     
         11 . The article of  claim 1 , wherein said polymerizable adhesive composition, after polymerization, substantially covers surfaces on at least a bottom side and a top side of said flexible material.  
     
     
         12 . The article of  claim 1 , wherein said polymerization initiator or rate modifier is immobilized on said flexible material.  
     
     
         13 . The article of  claim 1 , wherein said polymerization initiator or rate modifier is adsorbed or absorbed on said flexible material.  
     
     
         14 . The article of  claim 1 , wherein said polymerization initiator or rate modifier is chemically bonded to said flexible material.  
     
     
         15 . The article of  claim 1 , wherein said polymerization initiator or rate modifier is soluble or dispersible in said polymerizable adhesive composition  
     
     
         16 . The article of  claim 1 , further comprising a bioactive material disposed in or on said flexible material.  
     
     
         17 . The article of  claim 16 , wherein said bioactive material is chemically bonded to said flexible material.  
     
     
         18 . The article of  claim 16 , wherein said bioactive material is not immobilized on said flexible material, but is soluble or dispersible in said polymerizable adhesive composition.  
     
     
         19 . The article of  claim 1 , further comprising a non-bioactive material disposed in or on said flexible material.  
     
     
         20 . The article of  claim 19 , wherein said non-bioactive material is selected from the group consisting of colorants, scents, protective coatings that do not chemically detach, and temperature sensitive agents.  
     
     
         21 . The article of  claim 1 , wherein the flexible material is biodegradable.  
     
     
         22 . The article of  claim 1 , wherein the flexible material is not biodegradable.  
     
     
         23 . The article of  claim 1 , wherein the flexible material and the polymerizable adhesive composition are together biodegradable.  
     
     
         24 . The article of  claim 1 , wherein the flexible material and the polymerizable adhesive composition are together not biodegradable.  
     
     
         25 . The article of  claim 1 , wherein the article is opaque.  
     
     
         26 . The article of  claim 1 , wherein the article is translucent.  
     
     
         27 . The article of  claim 1 , wherein said flexible substrate does not include features that penetrate an underlying substrate during use.  
     
     
         28 . The article of  claim 1 , wherein said article is a tissue bonding article.  
     
     
         29 . A composite article, comprising: 
 a flexible material;    a polymerization initiator or rate modifier disposed in or on said flexible material; and    a polymerized adhesive composition permeated throughout at least a portion of said flexible material,    wherein said polymerization initiator or rate modifier is a polymerization initiator or rate modifier for said polymerizable adhesive composition.    
     
     
         30 . A method of bonding, comprising: 
 placing a flexible material over a substrate, wherein a polymerization initiator or rate modifier disposed in or on said flexible material;    applying a polymerizable adhesive composition over and substantially covering at least a portion of the flexible material; and    allowing the polymerizable adhesive composition to permeate into and under the flexible material and polymerize to form a composite structure bonded to said substrate.    
     
     
         31 . The method of  claim 30 , wherein said polymerization initiator or rate modifier is a polymerization initiator or rate modifier for said polymerizable adhesive composition.  
     
     
         32 . The method of  claim 30 , wherein said substrate is tissue.  
     
     
         33 . The method of  claim 30 , wherein said tissue is selected from the group consisting of bone, organ surfaces, skin, and mucous membranes.  
     
     
         34 . The method of  claim 30 , wherein said substrate is tissue is internal tissue.  
     
     
         35 . The method of  claim 30 , wherein said substrate is tissue is external tissue.  
     
     
         36 . The method of  claim 30 , wherein said substrate is a section of tissue that includes a wound to be closed.  
     
     
         37 . The method of  claim 36 , wherein said flexible material fully covers said wound.  
     
     
         38 . The method of  claim 30 , wherein said applying comprises: 
 placing a quantity of said polymerizable adhesive composition on an exposed side of the flexible material; and    spreading the quantity of polymerizable adhesive composition to substantially cover the flexible material.    
     
     
         39 . The method of  claim 30 , further comprising applying a polymerizable adhesive composition to said substrate prior to placing said flexible material over said substrate.  
     
     
         40 . The article of  claim 1 , wherein the flexible material is sterilized.  
     
     
         41 . The article of  claim 1 , wherein the polymerizable adhesive composition is sterilized.

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