Arylindenopyridines and related therapeutic and prophylactic methods

Abstract

This invention provides novel arylindenopyridines of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.

1 . A compound having the structure  
       
         
           
           
               
               
           
         
         wherein  
         (a) R 1  is selected from the group consisting of: 
 (i) —COR 5 , wherein R 5  is selected from H, optionally substituted C 1-8  straight or branched chain alkyl, optionally substituted aryl and optionally substituted arylalkyl;  
 
         wherein the substituents on the alkyl, aryl and arylalkyl group are selected from C 1-8  alkoxy, phenylacetyloxy, hydroxy, halogen, p-tosyloxy, mesyloxy, amino, cyano, carboalkoxy, or NR 20 R 21  wherein R 20  and R 21  are independently selected from the group consisting of hydrogen, C 1-8  straight or branched chain alkyl, C 3-7  cycloalkyl, benzyl, aryl, or heteroaryl or NR 20 R 21  taken together form a heterocycle or heteroaryl; 
 (ii) COOR 6 , wherein R 6  is selected from H, optionally substituted C 1-8  straight or branched chain alkyl, optionally substituted aryl and optionally substituted arylalkyl;  
 
         wherein the substituents on the alkyl, aryl and arylalkyl group are selected from C 1-8  alkoxy, phenylacetyloxy, hydroxy, halogen, p-tosyloxy, mesyloxy, amino, cyano, carboalkoxy, or NR 20 R 21  wherein R 20  and R 21  are independently selected from the group consisting of hydrogen, C 1-8  straight or branched chain alkyl, C 3-7  cycloalkyl, benzyl, aryl, or heteroaryl or NR 20 R 21  taken together form a heterocycle or heteroaryl; 
 (iii) cyano;  
 (iv) a lactone or lactam formed with R 4 ;  
 (v) —CONR 7 R 8  wherein R 7  and R 8  are independently selected from H, C 1-8  straight or branched chain alkyl, C 3-7  cycloalkyl, trifluoromethyl, hydroxy, alkoxy, acyl, alkylcarbonyl, carboxyl, arylalkyl, aryl, heteroaryl and heterocyclyl; 
 wherein the alkyl, cycloalkyl, alkoxy, acyl, alkylcarbonyl, carboxyl, arylalkyl, aryl, heteroaryl and heterocyclyl groups may be substituted with carboxyl, alkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heteroaryl, substituted heteroaryl, hydroxamic acid, sulfonamide, sulfonyl, hydroxy, thiol, alkoxy or arylalkyl,  
 or R 7  and R 8  taken together with the nitrogen to which they are attached form a heterocycle or heteroaryl group;  
 
 
         (b) R 2  is selected from the group consisting of optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl and optionally substituted C 3-7  cycloalkyl; or R 2  is  
         
           
             
             
                 
                 
             
           
         
         (c) R 3  is from one to four groups independently selected from the group consisting of: 
 (i) hydrogen, halo, C 1-8  straight or branched chain alkyl, arylalkyl, C 3-7  cycloalkyl, C 1-8  alkoxy, cyano, C 1-4  carboalkoxy, trifluoromethyl, C 1-8  alkylsulfonyl, halogen, nitro, hydroxy, trifluoromethoxy, C 1-8  carboxylate, aryl, heteroaryl, and heterocyclyl;  
 (ii) —NR 10 R 11  wherein R 10  and R 11  are independently selected from H, C 1-8  straight or branched chain alkyl, arylalkyl, C 3-7  cycloalkyl, carboxyalkyl, aryl, heteroaryl, and heterocyclyl or R 10  and R 11  taken together with the nitrogen form a heteroaryl or heterocyclyl group;  
 (iii) —NR 12 COR 13  wherein R 12  is selected from hydrogen or alkyl and R 13  is selected from hydrogen, alkyl, substituted alkyl, C 1-3  alkoxyl, carboxyalkyl, R 30 R 31 N (CH 2 ) p —, R 30 R 31 NCO(CH 2 ) p —, aryl, arylalkyl, heteroaryl and heterocyclyl or R 12  and R 13  taken together with the carbonyl form a carbonyl containing heterocyclyl group, wherein , R 30  and R 31  are independently selected from H, OH, alkyl, and alkoxy, and p is an integer from 1-6,  
 
         (d) R 4  is selected from the group consisting of (i) hydrogen, (ii) C 1-3  straight or branched chain alkyl, (iii) benzyl and (iv) —NR 13 R 14 , wherein R 13  and R 14  are independently selected from hydrogen and C 1-6  alkyl; 
 wherein the C 1-3 alkyl and benzyl groups are optionally substituted with one or more groups selected from C 3-7  cycloalkyl, C 1-8  alkoxy, cyano, C 1-4  carboalkoxy, trifluoromethyl, C 1-8  alkylsulfonyl, halogen, nitro, hydroxy, trifluoromethoxy, C 1-8  carboxylate, amino, NR 13 R 14 , aryl and heteroaryl; and  
 
         (e) X is selected from S and O;  
         with the proviso that when R 4  is isopropyl, then R 3  is not halogen, and with the proviso that one or more of R 1 , R 2 , R 3  or R 4  comprses heteroaryl or heterocycle and the pharmaceutically acceptable salts, esters and pro-drug forms thereof.  
       
     
     
         2 . The compound of  claim 1 , wherein R 1  is COOR 6 , wherein R 6  is selected from H, optionally substituted C 1-8  straight or branched chain alkyl, optionally substituted aryl and optionally substituted arylalkyl.  
     
     
         3 . The compound of  claim 2 , wherein R 6  is selected from H, or C 1-8  straight or branched chain alkyl which may be optionally substituted with a substituent selected from CN and hydroxy.  
     
     
         4 . The compound of  claim 1 , wherein R 2  is selected from optionally substituted aryl and optionally substituted heteroaryl.  
     
     
         5 . The compound of  claim 4  wherein the aryl or heteroaryl groups are substituted with one to five members selected from the group consisting of halogen, alkyl, alkoxy, alkoxyphenyl, halo, triflouromethyl, trifluoro or difluoromethoxy, amino, alkylamino, hydroxy, cyano, and nitro.  
     
     
         6 . The compound of  claim 4  wherein, R 2  is optionally substituted phenyl or napthyl or R 2  is  
       
         
           
           
               
               
           
         
       
       optionally substituted, wherein the optional substituents are from one to three members selected from the group consisting of halogen, alkyl, hydroxy, cyano, and nitro.  
     
     
         7 . The compound of  claim 1  wherein R 3  is selected from: 
 (i) hydrogen, halo, C 1-8  straight or branched chain alkyl, C 1-8  alkoxy, cyano, C 1-4  carboalkoxy, trifluoromethyl, C 1-8  alkylsulfonyl, halogen, nitro, and hydroxy;    (ii) —NR 10 R 11  wherein R 10  and R 11  are independently selected from H, C 1-8  straight or branched chain alkyl, arylC 1-8 alkyl, C 3 - 7  cycloalkyl, carboxyC 1-8 alkyl, aryl, heteroaryl, and heterocyclyl or R 10  and R 11  taken together with the nitrogen form a heteroaryl or heterocyclyl group;    (iii) —NR 12 COR 13  wherein R 12  is selected from hydrogen or alkyl and R 13  is selected from hydrogen, alkyl, substituted alkyl, C 1-3 alkoxyl, carboxyC 1-8 alkyl, aryl, arylalkyl, R 30 R 31 N (CH 2 ) p —, R 30 R 31 NCO(CH 2 ) p —, heteroaryl and heterocyclyl or R 12  and R 13  taken together with the carbonyl form a carbonyl containing heterocyclyl group, wherein, R 30  and R 31  are independently selected from H, OH, alkyl, and alkoxy, and p is an integer from 1-6.    
     
     
         8 . The compound of  claim 7 , wherein R 3  is selected from the group consisting of:  
       
         
           
           
               
               
           
         
       
     
     
         9 . The compound of  claim 1  wherein R 4  is selected from hydrogen, and C 1-3  straight or branched chain alkyl.  
     
     
         10 . The compound of  claim 9 , wherein R 4  is selected from methyl and amino.  
     
     
         11 . The compound of  claim 1  wherein R 1  is COOR 6  and R 2  is selected from the group consisting of substituted phenyl, and substituted naphthyl.  
     
     
         12 . The compound of  claim 1  wherein R 1  is COOR 6  where R 6  is alkyl, R 2  is substituted phenyl or naphthyl, and R 3  is selected from the group consisting of H, nitro, amino, NHAc, halo, hydroxy, alkoxy, or a moiety of the formulae:  
       
         
           
           
               
               
           
         
         and R 4  is selected from hydrogen, C 1-3  straight or branched chain alkyl and amino and X is Oxygen.  
       
     
     
         13 . A compound having the structure:  
       
         
           
           
               
               
           
         
         wherein  
         (a) R 1  is selected from the group consisting of: 
 (i) —COR 5 , wherein R 5  is selected from H, optionally substituted C 1-8  straight or branched chain alkyl, optionally substituted aryl and optionally substituted arylalkyl;  
 
         wherein the substituents on the alkyl, aryl and arylalkyl group are selected from C 1-8  alkoxy, phenylacetyloxy, hydroxy, halogen, p-tosyloxy, mesyloxy, amino, cyano, carboalkoxy, or NR 20 R 21  wherein R 20  and R 21  are independently selected from the group consisting of hydrogen, C 1-8  straight or branched chain alkyl, C 3-7  cycloalkyl, benzyl, aryl, or heteroaryl or NR 20 R 21  taken together form a heterocycle or heteroaryl; 
 (ii) COOR 6 , wherein R 6  is selected from H, optionally substituted C 1-8  straight or branched chain alkyl, optionally substituted aryl and optionally substituted arylalkyl;  
 
         wherein the substituents on the alkyl, aryl and arylalkyl group are selected from C 1-8  alkoxy, phenylacetyloxy, hydroxy, halogen, p-tosyloxy, mesyloxy, amino, cyano, carboalkoxy, or NR 20 R 21  wherein R 20  and R 21  are independently selected from the group consisting of hydrogen, C 1-8  straight or branched chain alkyl, C 3-7  cycloalkyl, benzyl, aryl, or heteroaryl or NR 20 R 21  taken together form a heterocycle or heteroaryl; 
 (iii) cyano;  
 (iv) a lactone or lactam formed with R 4 ;  
 (v) —CONR 7 R 8  wherein R 7  and R 8  are independently selected from H, C 1-8  straight or branched chain alkyl, C 3-7  cycloalkyl, trifluoromethyl, hydroxy, alkoxy, acyl, alkylcarbonyl, carboxyl, arylalkyl, aryl, heteroaryl and heterocyclyl; 
 wherein the alkyl, cycloalkyl, alkoxy, acyl, alkylcarbonyl, carboxyl, arylalkyl, aryl, heteroaryl and heterocyclyl groups may be substituted with carboxyl, alkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heteroaryl, substituted heteroaryl, hydroxamic acid, sulfonamide, sulfonyl, hydroxy, thiol, alkoxy or arylalkyl,  
 or R 7  and R 8  taken together with the nitrogen to which they are attached form a heterocycle or heteroaryl group;  
 
 
         (b) R 2  is —NR 15 R 16  wherein R 15  and R 16  are independently selected from hydrogen, optionally substituted C 1-8  straight or branched chain alkyl, arylalkyl, C 3-7  cycloalkyl, aryl, heteroaryl, and heterocyclyl or R 15  and R 16  taken together with the nitrogen form a heteroaryl or heterocyclyl group; with the proviso that when R 2  is NHR 16 , R 1  is not —COOR 6  where R 6  is ethyl;  
         (c) R 3  is from one to four groups independently selected from the group consisting of: 
 (i) hydrogen, halo, C 1-8  straight or branched chain alkyl, arylalkyl, C 3-7  cycloalkyl, C 1-8  alkoxy, cyano, C 1-4  carboalkoxy, trifluoromethyl, C 1-8  alkylsulfonyl, halogen, nitro, hydroxy, trifluoromethoxy, C 1-8  carboxylate, aryl, heteroaryl, and heterocyclyl;  
 (ii) —NR 10 R 11  wherein R 10  and R 11  are independently selected from H, C 1-8  straight or branched chain alkyl, arylalkyl, C 3-7  cycloalkyl, carboxyalkyl, aryl, heteroaryl, and heterocyclyl or R 10  and R 11  taken together with the nitrogen form a heteroaryl or heterocyclyl group;  
 (iii) —NR 12 COR 13  wherein R 12  is selected from hydrogen or alkyl and R 13  is selected from hydrogen, alkyl, substituted alkyl, C 1-3 alkoxyl, carboxyalkyl, R 30 R 31 N (CH 2 ) p —, R 30 R 31 NCO(CH 2 ) p —, aryl, arylalkyl, heteroaryl and heterocyclyl or R 12  and R 13  taken together with the carbonyl form a carbonyl containing heterocyclyl group, wherein, R 30  and R 31  are independently selected from H, OH, alkyl, and alkoxy, and p is an integer from 1-6, wherein the alkyl group may be substituted with carboxyl, alkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heteroaryl, substituted heteroaryl, hydroxamic acid, sulfonamide, sulfonyl, hydroxy, thiol, alkoxy or arylalkyl;  
 
         (d) R 4  is selected from the group consisting of (i) hydrogen, (ii) C 13  straight or branched chain alkyl, (iii) benzyl and (iv) —NR 13 R 14 , wherein R 13  and R 14  are independently selected from hydrogen and C 1-6  alkyl; 
 wherein the C 1-3 alkyl and benzyl groups are optionally substituted with one or more groups selected from C 3-7  cycloalkyl, C 1-8  alkoxy, cyano, C 1-4  carboalkoxy, trifluoromethyl, C 1-8  alkylsulfonyl, halogen, nitro, hydroxy, trifluoromethoxy, C 1-8  carboxylate, amino, NR 13 R 14 , aryl and heteroaryl; and  
 
         (e) X is selected from S and O;  
         with the proviso that one or more of R 1 , R 2 , R 3  or R 4  comprises heteroaryl or heterocycle and the pharmaceutically acceptable salts, esters and pro-drug forms thereof.  
       
     
     
         14 . The compound of  claim 13 , wherein R 1  is COOR 6  wherein R 6  is alkyl, R 2  is NR 6 R 7 , and R 3  is selected from the group consisting of  
       
         
           
           
               
               
           
         
         halogen, and hydrogen, and R 4  is selected from hydrogen, C 1-3  straight or branched chain alkyl and amino and X is Oxygen.  
       
     
     
         15 - 47 . (canceled)