Inhibition of tau-tau-association

Abstract

A composition and use thereof for the prophylaxis or treatment of Alzheimer's disease, motor neurone disease, Lewy body disease, Pick's disease or progressive supranuclear palsy. The composition includes an agent which modulates or inhibits tau-tau association and which does not inhibit tau-tubulin binding. In the method the agent is administered to an individual in order to achieve the desired therapeutic effect. Preferably the agent which is administered is a phenothiazine compound.

1 . A method of screening for an agent that modulates or inhibits tau-tau association comprising contacting 
 a) a tau protein or a derivative thereof containing the tau core fragment and which is bound to a solid phase with    b) an agent suspected of being capable of modulating or inhibiting tau-tau association and    c) a labelled tau protein or a labelled derivative thereof capable of binding to a tau protein or a tau protein or a derivative thereof which is distinct from the tau protein of a) and capable of binding to a tau protein and    d) detection of the tau-tau binding.    
     
     
         2 - 25 . (canceled)