Method of treating diabetes and obesity using carbohydrate absorption inhibitors

Abstract

This invention provides carbohydrate absorption inhibitor derived from evening primrose seed which is significantly effective to prevent and cure diabetes mellitus and prevent obesity, and the manufacturing method of the same. Carbohydrate absorption inhibitor in this invention is characterized that the effective component is an alcohol extract of evening primrose seed. The aforementioned evening primrose seed is preferably a defatted evening primrose seed. Extracting solvent of the aforementioned evening primrose seed is preferably ethanol, or preferably a 70 to 85% (v/v) aqueous ethanol. Also, this invention is characterized that the carbohydrate absorption inhibitor is an effective component of polyphenol derived from evening primrose seed. The polyphenol is preferably one or more substances selected from among gallic acid, ellagic acid, catechin, pentagalloylglucose, procyanidin, and proantocyanidin. The manufacturing method of the carbohydrate absorption inhibitor in this invention is characterized to be composed of the following processes A to C. Process A: evening primrose is compressed, oil is separated then the compressed cake is obtained. Process B: The aforementioned compressed cake is defatted in fat-soluble organic solvent, and defatted substance is obtained. Process C: The aforementioned defatted substance is extracted by alcohol, and then this extracted liquid is concentrated or evaporated.

1 - 6 . (canceled)  
     
     
         7 . In a method of administering treatment to a patient suffering from diabetes mellitus, the improvement comprising administering to the patient an effective amount of an carbohydrate absorption inhibitor comprising an effective component of solvent extract of compressed cake derived from defatted evening primrose seed and wherein the effective component contains polyphenol—essential elements comprising ellagic acid, gallic acid, pentagalloylglucose and catechin.  
     
     
         8 . In a method of administering treatment to patients suffering from obesity, the improvement comprising administering to the patients an effective amount of the carbohydrate absorption inhibitor comprising an effective component of solvent extract of compressed cake derived from defatted evening primrose seed and wherein the effective component contains polyphenol—essential elements comprising ellagic acid, gallic acid, pentagalloylglucose and catechin.  
     
     
         9 . The method of  claim 7 , wherein an extracting solvent of the compressed cake derived from the evening primrose seed is 55 to 99% (v/v) aqueous ethanol.  
     
     
         10 . The method of  claim 8 , wherein an extracting solvent of the compressed cake derived from the evening primrose seed is 55 to 99% (v/v) aqueous ethanol.  
     
     
         11 . The method of  claim 9 , wherein an extracting solvent of the compressed cake derived from the evening primrose seed is 70 to 85% (v/v) aqueous ethanol.  
     
     
         12 . The method of  claim 10 , wherein an extracting solvent of the compressed cake derived from the evening primrose seed is 70 to 85% (v/v) aqueous ethanol.  
     
     
         13 . The method of  claim 7 , wherein a fat-soluble organic solvent is used in when defatting the evening primrose seed.  
     
     
         14 . The method of  claim 8 , wherein a fat-soluble organic solvent is used in when defatting the evening primrose seed.  
     
     
         15 . The method of  claim 7 , wherein patients receive the effective amount of the carbohydrate either orally or by injection.  
     
     
         16 . The method of  claim 8 , wherein patients receive the effective amount of the carbohydrate either orally or by injection.  
     
     
         17 . The method of  claim 7 , wherein oil is removed from the evening primrose seed by first compressing the seed into a cake for oil removal, and then using a solvent to remove remaining oil from the cake.  
     
     
         18 . The method of  claim 8 , wherein oil is removed from the evening primrose seed by first compressing the seed into a cake for oil removal, and then using a solvent to remove remaining oil from the cake.