Crystal modificaion of a N-phenyl-2-pyrimidineamine derivative, processed for its manufacture and its use

Abstract

The invention relates to a new crystalline form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of formula 1, which may be used for example for tumour therapy.

1 - 12 . (canceled)  
     
     
         13 . The methanesulfonate salt of a compound of formula I,  
       
         
           
           
               
               
           
         
       
     
     
         14 . A process for the preparation of the methansulfonate of a compound of formula I according to claim  1  wherein the free base of formula I is reacted with an equimolar amount of methanesulfonic acid under reflux in ethanol.  
     
     
         15 . The use of the methansulfonate salt of a compound of formula I according to claim  1  for the preparation of a β-crystal form of the methansulfonate salt of a compound of formula I.