Silicone hydrogel contact lens

Abstract

Ophthalmically compatible contact lenses include lens bodies configured for placement on a cornea of an animal or human eye. The lens bodies are made of a hydrophilic silicon-containing polymeric material. The lens bodies have oxygen permeabilities, water content, surface wettabilities, flexibilities, and/or designs to be worn by a lens wearer even during sleep. The present lenses can be worn on a daily basis, including overnight, or can be worn for several days, such as about thirty days, without requiring removal or cleaning.

1 . A silicone hydrogel contact lens, comprising a non-surface treated lens body comprising a hydrophilic, silicon-containing polymeric material, the lens body having at least one of an oxygen permeability, a water content, a surface wettability, a modulus, and a design effective in facilitating ophthalmically compatible wearing of the contact lens by a lens wearer at least for one day.  
     
     
         2 . The contact lens of  claim 1 , wherein the lens body has an oxygen permeability, a water content, a surface wettability, a modulus, and a design effective in facilitating ophthalmically compatible wearing of the contact lens by the lens wearer at least for one day.  
     
     
         3 . The contact lens of  claim 1 , wherein the lens body has an oxygen permeability, a water content, a surface wettability, a modulus, and a design effective in facilitating ophthalmically compatible wearing of the contact lens by the lens wearer for about thirty days.  
     
     
         4 . The contact lens of  claim 1 , wherein the polymeric material comprises units from one silicon-containing macromer.  
     
     
         5 . The contact lens of  claim 1 , wherein the polymeric material comprises units from two different silicon-containing macromers, each macromer having a different molecular weight.  
     
     
         6 . The contact lens of  claim 1 , wherein the lens body has an oxygen permeability of at least about 70 barrers, a water content of at least about 30% by weight, a modulus less than about 1.4 mPa, and a contact angle on a surface of the lens body less than about 60 degrees.  
     
     
         7 . The contact lens of  claim 6 , wherein the lens body has an oxygen permeability greater than about 110 barrers.  
     
     
         8 . The contact lens of  claim 6 , wherein the lens body has a water content greater than about 45% by weight.  
     
     
         9 . The contact lens of  claim 6 , wherein the lens body has a modulus less than about 0.9 mPa.  
     
     
         10 . The contact lens of  claim 6 , wherein the lens body has an oxygen permeability of at least about 115 barrers, a water content of about 48% by weight, and a modulus of about 0.84 mPa.  
     
     
         11 . The contact lens of  claim 6 , wherein the lens body has an oxygen permeability from about 70 barrers to about 100 barrers, a water content of at least about 50% by weight, and a modulus from about 0.3 mPa to about 0.5 mPa.  
     
     
         12 . A contact lens comprising a lens body comprising a hydrophilic, silicon-containing polymeric material, the lens body having a Dk of greater than about 110 barrers and an equilibrium water content of greater than about 30% by weight, the contact lens being ophthalmically compatible.  
     
     
         13 . The contact lens of  claim 1  wherein the lens body has a Dk of at least about 150 barrers.  
     
     
         14 . The contact lens of  claim 12 , wherein the lens body has an equilibrium water content of at least about 35% by weight.  
     
     
         15 . The contact lens of  claim 12 , wherein the lens body has an anterior surface and a posterior surface, and at least one of the anterior and posterior surfaces is not modified.  
     
     
         16 . The contact lens of  claim 15 , wherein both the anterior and posterior surfaces are not modified.  
     
     
         17 . The contact lens of  claim 12 , wherein the lens body has a modulus of about 1.4 mPa or less.  
     
     
         18 . The contact lens of  claim 12 , wherein the lens body has an elongation of at least about 90%.  
     
     
         19 . The contact lens of  claim 12 , wherein the lens body has an ionoflux of no greater than about 5 10 −3  mm 2 /min.  
     
     
         20 . The contact lens of  claim 12 , wherein the polymeric material comprises units from one silicon-containing macromer.  
     
     
         21 . The contact lens of  claim 12 , wherein the polymeric material comprises units from two silicon-containing macromers having different molecular weights.  
     
     
         22 . The contact lens of  claim 21 , wherein units from a high molecular weight silicon-containing macromer are present in a greater amount by weight in the polymeric material than units from a low molecular weight silicon-containing macromer.  
     
     
         23 . The contact lens of  claim 21 , wherein the polymeric material comprises units from a silicon-containing macromer having a number average molecular weight of at least about 10,000.  
     
     
         24 . The contact lens of  claim 21  wherein the two silicon-containing macromers have number average molecular weights which differ by at least about 5,000.  
     
     
         25 . The contact lens of  claim 22 , wherein units from the high molecular weight silicon-containing macromer are at least about 40% by weight of the polymeric material.  
     
     
         26 . The contact lens of  claim 22 , wherein units from the high molecular weight silicon-containing macromer and from the low molecular weight silicon-containing macromer total at least about 50% by weight of the polymeric material.  
     
     
         27 . The contact lens of  claim 21 , wherein one of the silicon-containing macromers is mono-functional.  
     
     
         28 . The contact lens of  claim 21 , wherein the polymeric material comprise units from a plurality of hydrophilic monomers.  
     
     
         29 . A contact lens comprising a lens body comprising a hydrophilic, silicon-containing polymeric material, the lens body having a Dk of greater than about 70 barrers and an equilibrium water content of greater than about 30% by weight, the lens body being produced without surface treatment, the contact lens being ophthalmically compatible.  
     
     
         30 . The contact lens of  claim 29 , wherein the lens body has a Dk of at least about 90 barrers.  
     
     
         31 . The contact lens of  claim 29 , wherein the lens body has an equilibrium water content of at least about 35% by weight.  
     
     
         32 . The contact lens of  claim 29 , wherein the lens body has a modulus of about 1.4 mPa or less.  
     
     
         33 . The contact lens of  claim 29 , wherein the lens body has an elongation of at least about 90%.  
     
     
         34 . The contact lens of  claim 29 , wherein the lens body has an ionoflux of no greater than about 5 10 −3  mm 2 /min.  
     
     
         35 . The contact lens of  claim 29 , wherein the polymeric material comprises units from one silicon-containing macromer.  
     
     
         36 . The contact lens of  claim 29 , wherein the polymeric material comprise units from two silicon-containing macromers having different molecular weights.  
     
     
         37 . The contact lens of  claim 36 , wherein the polymeric material comprises units from a plurality of hydrophilic monomers.  
     
     
         38 . A contact lens comprising a lens body comprising a hydrophilic, silicon-containing polymeric material, the lens body having a Dk of greater than 100 barrers, an equilibrium water content of greater than about 30% by weight, and an ionoflux no greater than about 5 10 −3  mm 2 /min, the contact lens being ophthalmically compatible.  
     
     
         39 . The contact lens of  claim 38 , wherein the lens body has a Dk of at least about 130 barrers.  
     
     
         40 . The contact lens of  claim 38 , wherein the lens body has an equilibrium water content of at least about 35% by weight.  
     
     
         41 . The contact lens of  claim 38 , wherein the lens body has an anterior surface and a posterior surface, and at least one of the anterior and posterior surfaces is not treated.  
     
     
         42 . The contact lens of  claim 41 , wherein both the anterior and posterior surfaces are not treated.  
     
     
         43 . The contact lens of  claim 38 , wherein the lens body has a modulus of about 1.4 mPa or less.  
     
     
         44 . The contact lens of  claim 38 , wherein the polymeric material comprise units from two silicon-containing macromers having different molecular weights.  
     
     
         45 . The contact lens of  claim 38 , wherein the polymeric material comprises units from a plurality of hydrophilic monomers.  
     
     
         46 . A contact lens comprising a lens body comprising a hydrophilic, silicon-containing polymeric material, the lens body having an equilibrium water content of greater than about 15% by weight, the polymeric material comprises units from two silicon-containing macromers having different molecular weights, the lens body being ophthalmically compatible.  
     
     
         47 . The contact lens of  claim 46 , wherein one of the macromers has a number average molecular weight greater than about 10,000.  
     
     
         48 . The contact lens of  claim 46 , wherein the polymeric material comprises units from a plurality of hydrophilic monomers.  
     
     
         49 . The contact lens of  claim 46 , wherein the lens body has a Dk of at least about 70 barrers.  
     
     
         50 . The contact lens of  claim 46 , wherein the lens body has an equilibrium water content of at least about 30% by weight.  
     
     
         51 . The contact lens of  claim 46 , wherein the lens body has an anterior surface and a posterior surface, and at least one of the anterior and posterior surfaces is not treated.  
     
     
         52 . The contact lens of  claim 46 , wherein the lens body comprises no surface treatment.  
     
     
         53 . The contact lens of  claim 46 , wherein the lens body has a modulus of about 1.4 mPa or less.  
     
     
         54 . The contact lens of  claim 46 , wherein the lens body has an ionoflux of no greater than about 5 10 −3  mm 2 /min.  
     
     
         55 . The contact lens of  claim 46 , wherein the lens body has an elongation of at least about 90%.