Oxazinones and methods for their use and synthesis

Abstract

The invention pertains, at least in part, to new intermediates and synthetic methods for the stereospecific synthesis of oxazinone compounds, which are useful, for example, as antibiotics. The invention also pertains to novel olefinic oxazinone compounds, methods for their synthesis, and methods of using these compounds for the synthesis of oxazinones. The invention also pertains to methods for using the compounds to treat bacterial associated states in subjects.

1 . An olefinic oxazinone of the formula (I):  
       
         
           
           
               
               
           
         
       
       wherein: 
 R 1  is an amino acid side chain mimicking moiety;  
 R 4 , R 6 , R 8 , and R 9  are substituting moieties;  
 R 7  is hydrogen, a protecting moiety, or a prodrug moiety, and acceptable salts and esters thereof.