Dalbavancin compositions for treatment of bacterial infections

Abstract

The invention provides methods and compositions for treatment of bacterial infections. The composition may be a combination of factors, which include A 0 , A 1 , B 1 , B 2 , C 0 , C 1 , isoB 0 , and MAG, in the presence of low level solvent. Methods of the invention include administration of dalbavancin formulations for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Dosing regimens include multiple dose administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection. Dosing regimens for renal patients are also included.

1 - 69 . (canceled)  
     
     
         70 . A chemical compound of the formula  
       
         
           
           
               
               
           
         
       
       wherein R 2  is a C 10-14  acyl.  
     
     
         71 . The compound of  claim 70 , wherein R 2  is selected from the group consisting of 8-methyl nonanoic acid, n-decanoic acid, 9-methyl-decanoic acid, n-undecanoic acid, 10-methyl-undecanoic acid, n-dodecanoic acid, 11-methyl-dodecanoic acid, n-tridecanoic acid, 12-methyl-tridecanoic acid, and n-tetradecanoic acid.  
     
     
         72 . The compound of  claim 70 , wherein R 2  is 10-methyl-undecanoic acid.  
     
     
         73 . A compound of the formula  
       
         
           
           
               
               
           
         
       
     
     
         74 . A compound according to formula 1, or a pharmaceutically acceptable salt or solvate thereof:  
       
         
           
           
               
               
           
         
       
       wherein: 
 M is hydrogen, α-D-mannopyrannosyl, or 6-O-acetyl-α-D-mannopyrannosyl;  
 G is hydrogen, glucuronamine or acylglucuronamine; and  
 X is an aminoalkylamino.  
 
     
     
         75 . The compound of  claim 74 , having formula 2:  
       
         
           
           
               
               
           
         
       
     
     
         76 - 163 . (canceled)