Specificity exchangers that redirect antibodies to a pathogen

Abstract

Specificity exchangers and methods of making and using specificity exchangers are disclosed. Specificity exchangers are useful for preventing and treating human diseases including cancer and those resulting from pathogens such as bacteria, yeast, parasites, fungus, viruses, and the like. More specifically, specificity exchangers can redirect existing antibodies in a subject to pathogens and cancer cells.

1 . A ligand/receptor specificity exchanger comprising at least one specificity domain comprising a fragment of a ligand for a bacterial receptor joined to an oligo/polysaccharide.  
     
     
         2 . The ligand/receptor specificity exchanger of  claim 1 , wherein said specificity domain comprises at least 3 and up to 27 consecutive amino acids of a ligand for a bacterial receptor.  
     
     
         3 . The ligand/receptor specificity exchanger of  claim 1 , wherein said specificity domain contains between 3-200 consecutive amino acids of a ligand for a bacterial receptor.  
     
     
         4 . The ligand/receptor specificity exchanger of  claim 1 , wherein said specificity domain contains between 5-100 consecutive amino acids of a ligand for a bacterial receptor.  
     
     
         5 . The ligand/receptor specificity exchanger of  claim 1 , wherein said specificity domain contains between 8-50 consecutive amino acids of a ligand for a bacterial receptor.  
     
     
         6 . The ligand/receptor specificity exchanger of  claim 1 , wherein said specificity domain contains between 10-25 consecutive amino acids of a ligand for a bacterial receptor.  
     
     
         7 . The ligand/receptor specificity exchanger of  claim 1 , wherein said specificity domain contains between 3-20 consecutive amino acids of a ligand for a bacterial receptor.  
     
     
         8 . The ligand/receptor specificity exchanger of  claim 1 , wherein said specificity domain contains between 3-30 consecutive amino acids of a ligand for a bacterial receptor.  
     
     
         9 . The ligand/receptor specificity exchanger of  claim 1 , wherein said specificity domain comprises at least three consecutive amino acids of fibrinogen.  
     
     
         10 . The ligand/receptor specificity exchanger of  claim 1 , wherein said specificity domain is selected from the group consisting of fibrinogen, collagen, vitronectin, laminin, plasminogen, thrombospondin, and fibronectin.  
     
     
         11 . The ligand/receptor specificity exchanger of  claim 1 , wherein said bacterial receptor is selected from the group consisting of extracellular fibrinogen binding protein (Efb), collagen binding protein, vitronectin binding protein, laminin binding protein, plasminogen binding protein, thrombospondin binding protein, clumping factor A (ClfA), clumping factor B (ClfB), fibronectin binding protein, coagulase, and extracellular adherence protein.  
     
     
         12 . The ligand/receptor specificity exchanger of  claim 6 , comprising a sequence selected from the group consisting of SEQ. ID. No. 1, SEQ. ID. No. 2, SEQ. ID. No. 3, SEQ. ID. No. 4, SEQ. ID. No. 5, SEQ. ID. No. 6, SEQ. ID. No. 7, SEQ. ID. No. 8, SEQ. ID. No. 9, SEQ. ID. No. 10, SEQ. ID. No. 11, SEQ. ID. No. 12, SEQ. ID. No. 13, SEQ. ID. No. 14, SEQ. ID. No. 15, SEQ. ID. No. 16, SEQ. ID. No. 17, SEQ. ID. No. 18, SEQ. ID. No. 19, SEQ. ID. No. 20, SEQ. ID. No. 21, SEQ. ID. No. 22, SEQ. ID. No. 23, SEQ. ID. No. 24, SEQ. ID. No. 25, SEQ. ID. No. 26, SEQ. ID. No. 27, SEQ. ID. No. 28, SEQ. ID. No. 29, SEQ. ID. No. 30, SEQ. ID. No. 31, SEQ. ID. No. 32, SEQ. ID. No. 33, SEQ. ID. No. 34, SEQ. ID. No. 35, SEQ. ID. No. 36, SEQ. ID. No. 37, SEQ. ID. No. 38, SEQ. ID. No. 39, SEQ. ID. No. 40, SEQ. ID. No. 41, SEQ. ID. No. 42, SEQ. ID. No. 43, SEQ. ID. No. 44, SEQ. ID. No. 45, SEQ. ID. No. 46, and SEQ. ID. No. 47.  
     
     
         13 . A ligand/receptor specificity exchanger comprising at least one specificity domain comprising a fragment of a ligand for a bacterial receptor joined to a carbohydrate.