Dental whitening compositions

Abstract

A two-component whitening system has a de-sensitizing effect as well as re-mineralizing capability. The system may be an unfoamed, a foamed or a foamable composition. The system has a first component with at least one peroxide compound, at least one source of phosphate and at least one gelling agent; and a second component with at least one source of calcium, strontium and/or mixtures thereof. The second component may also contain at least one gelling agent, and the composition maybe present as a foam or is foamable. The composition may be packed in a two-compartment syringe.

1 . A two-component whitening system comprising: 
 a first component comprising at least one peroxide compound, at least one source of phosphate and at least one gelling agent; and    a second component comprising at least one source of calcium, strontium or mixtures thereof, and at least one gelling agent.    
   
   
       2 . The two-component system of  claim 1  wherein said second component comprises at least one peroxide compound.  
   
   
       3 . The two-component system of  claim 1  wherein said second component further comprises an ingredient selected from a group consisting of a de-sensitizing agent, an antibacterial agent, a fluoridating agent, a vitamin supplement, an anti-staining agent, an anti-plaque agent and mixtures thereof.  
   
   
       4 . The two-component system of  claim 1  wherein the first component s visually distinguishable from the second component.  
   
   
       5 . The two-component system of  claim 1  wherein the components are adapted to be admixed and applied to the teeth from a dental tray for sustained contact.  
   
   
       6 . The two-component system of  claim 1  wherein the peroxide present in the whitening gel ranges from about 0.5% by weight to about 45% by weight.  
   
   
       7 . The two-component system of  claim 1  wherein the peroxide present in the whitening gel ranges from about 1% by weight to about 35% by weight.  
   
   
       8 . The two-component system of  claim 1  wherein the source of phosphate in the first component is selected from the group consisting of monosodium phosphate (NaH 2 PO 4 ), disodium phosphate, tetrapotassium pyrophosphate and mixtures thereof.  
   
   
       9 . The two-component system of  claim 1  wherein the source of phosphate in the first component is present in an amount of from about 0.2% to about 5% by weight.  
   
   
       10 . The two-component system of  claim 1  wherein the source of calcium or strontium, or combinations thereof in the second component comprises a calcium salt, a strontium salt, or mixtures thereof.  
   
   
       11 . The two-component system of  claim 1  wherein said source of calcium in the second component comprises calcium nitrate.  
   
   
       12 . The two-component system of  claim 1  wherein said source of calcium, strontium or combinations thereof in the second component comprises an amount of from about 0.25% by weight to about 1.5% by weight.  
   
   
       13 . The two component system of  claim 1  wherein said source of phosphate in the first component combines with the source of calcium, strontium or combinations thereof in the second component to form various amorphous calcium and/or strontium phosphates.  
   
   
       14 . The two-component system of  claim 3  wherein the de-sensitizing agent comprises potassium nitrate.  
   
   
       15 . The two-component system of  claim 15  wherein potassium nitrate is present up to about 5% by weight of the system.  
   
   
       16 . The two-component system of  claim 1  further comprising a de-sensitizing agent is the first component.  
   
   
       17 . The two-component system of  claim 1  wherein said system is foamable.  
   
   
       18 . A two-compartment container comprising a two-component whitening system, comprising: 
 a first component comprising at least one peroxide compound, at least one source of phosphate and at least one gelling agent; and    a second component comprising at least one source of calcium, strontium or mixtures thereof, and at least one gelling agent.    
   
   
       19 . The two-compartment container of  claim 18  wherein said system is foamable.  
   
   
       20 . The two-compartment container of  claim 18  wherein the source of phosphate in the first compartment is selected from the group consisting of monosodium phosphate (NaH 2 PO 4 ), disodium phosphate, tetrapotassium pyrophosphate and mixtures thereof.  
   
   
       21 . The two-compartment container of  claim 18  wherein source of calcium or strontium, or combinations thereof in the second compartment comprises a calcium salt, a strontium salt, or mixtures thereof.  
   
   
       22 . The two-compartment container of  claim 18  wherein said container comprises a dual-barrel syringe.  
   
   
       23 . The two-compartment container of  claim 18  further comprising a dispensing device selected from the group consisting of a dispensing tip, a pump, a mixer and combinations thereof.  
   
   
       24 . The two-compartment container of  claim 22  wherein the syringe comprises a dispensing device adapted for foaming selected from the group consisting of a dispensing tip, a pump, a mixer and combinations thereof.  
   
   
       25 . The two-compartment container of  claim 18  wherein said system is foamed;  
   
   
       26 . The two-compartment container of  claim 25  wherein said foamed system has a half life of at least about 1 month.  
   
   
       27 . The two-compartment container of  claim 18  wherein said system comprises at least one foaming agent.  
   
   
       28 . The two-compartment container of  claim 18  wherein said system further comprises an ingredient selected from a group consisting of a de-sensitizing agent, an antibacterial agent, a fluoridating agent, a vitamin supplement, an anti-staining agent, an anti-plaque agent and mixtures thereof.  
   
   
       29 . A foamable two-component whitening system comprising: 
 a first component comprising at least one peroxide compound, at least one source of phosphate and at least one gelling agent; and    a second component comprising at least one source of calcium, strontium or mixtures thereof and at least one foaming agent;    wherein the resulting foam has a half life of at least about 1 hour.    
   
   
       30 . The foamable system of  claim 29  wherein the source of phosphate in the first component is selected from the group consisting of monosodium phosphate (NaH 2 PO 4 ), disodium phosphate, tetrapotassium pyrophosphate and mixtures thereof.  
   
   
       31 . The foamable two-component system of  claim 29  wherein the source of phosphate in the first component is present in an amount of from about 0.2% to about 5% by weight.  
   
   
       32 . The foamable two-component system of  claim 29  wherein the source of calcium or strontium, or combinations thereof in the second component comprises a calcium salt, a strontium salt, or mixtures thereof.  
   
   
       33 . The foamable two-component system of  claim 29  wherein said source of calcium, strontium or combinations thereof in the second component comprises an amount of from about 0.25% by weight to about 1.5% by weight.  
   
   
       34 . The foamable two-component system of  claim 29  wherein said foaming agent is selected from the group consisting of surfactants, alkali metal carbonates and bicarbonates, alkaline metal carbonates and bicarbonates, gases and mixtures thereof.  
   
   
       35 . The foamable two-component system of  claim 34  wherein said surfactant comprises ionic, non-ionic and amphoteric surfactants.  
   
   
       36 . The foamable two-component system of  claim 34  wherein said surfactant is selected from the group consisting of sodium lauryl sulfate, compounds comprising a hydrophilic and hydrophobic component, phospholipids, and mixtures thereof.  
   
   
       37 . The foamable two-component system of  claim 29  further comprising an ingredient selected from a group consisting of a de-sensitizing agent, an antibacterial agent, a fluoridating agent, a vitamin supplement, an anti-staining agent, an anti-plaque agent and mixtures thereof