Device and method for delivering an oral care agent

Abstract

An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an oral care layer, and a non-woven binding material with a first part that is substantially invested in the oral care layer and a second part that is substantially invested in the backing layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.

1 . A device for delivering an oral care agent, wherein the device is sized to fit over a plurality of teeth in an upper or lower dental arch in a subject, the device comprising: 
 a permanently deformable backing layer;    a non-woven binding material comprising a first part and a second part; and    an oral care layer comprising at least one oral care agent and at least one hydrophilic polymer, wherein the first part of the binding material is substantially invested in at least a portion of the oral care layer, and the second part of the binding material is substantially invested in at least a portion of the backing layer, and    wherein the oral care layer has an adhesiveness when hydrated relative to the surface of the teeth of the subject that is sufficient to retain the device on the user's teeth when placed thereon.    
   
   
       2 . The device of  claim 1 , wherein the backing layer is from about 0.025 mm to about 0.508 mm thick.  
   
   
       3 . The device of  claim 1 , wherein the backing layer is from about 0.125 mm to about 0.457 mm thick.  
   
   
       4 . The device of  claim 1 , wherein the backing layer is about 0.38 mm thick.  
   
   
       5 . The device of  claim 1 , wherein the backing layer comprises a non-polymeric material.  
   
   
       6 . The device of  claim 5 , wherein the non-polymeric material comprises a wax, a resin, or mixtures thereof.  
   
   
       7 . The device of  claim 6 , wherein the wax is selected from the group consisting of a microcrystalline wax; a paraffin wax; a synthetic paraffin wax; and mixtures thereof.  
   
   
       8 . The device of  claim 6 , wherein the resin is a hydrocarbon resin.  
   
   
       9 . The device of  claim 8 , wherein the hydrocarbon resin is a water-white, clear cycloaliphatic hydrocarbon resin.  
   
   
       10 . The device of  claim 1  wherein the backing layer is colored.  
   
   
       11 . The device of  claim 10  wherein the backing layer is colored with at least one colorizing compound.  
   
   
       12 . The device of  claim 11  wherein the at least one colorizing compound is selected from the group consisting of FD&C Red No. 3; Food Red 17; Food Yellow 13; FD&C Yellow No. 5; FD&C Yellow No. 6; FD&C Green No. 3; FD&C Blue No. 1; FD&C Blue No. 2; FD&C Red No. 40; Orange B; Citrus Red No. 2; and combinations thereof.  
   
   
       13 . The device of  claim 11  wherein the at least one colorizing compound is selected from the group consisting of annatto extract; beta-apo-8′-carotenal; beta-carotene; beet powder; canthaxanthin; caramel color; carrot oil; cochineal extract (carmine); toasted, partially defatted, cooked cottonseed flour; ferrous gluconate; fruit juice; grape color extract; grape skin extract (enocianina); paprika; paprika oleoresin; riboflavin; saffron; turmeric; turmeric oleoresin; vegetable juice; and combinations thereof.  
   
   
       14 . The device of  claim 11  wherein the at least one colorizing compound is selected from the group consisting of titanium dioxide; chromium oxide greens; ultramarine blues and pinks; and ferric oxides.  
   
   
       15 . The device of  claim 11 , wherein the dye comprises a dye-lake form.  
   
   
       16 . The device of  claim 15 , wherein the dye-lake form is selected from the group consisting of FD&C Green #1 lake; FD&C Blue #2 lake; FD&C R&D #30 lake; and FD&C Yellow #15 lake.  
   
   
       17 . The device of  claim 11 , wherein the at least one colorizing compound comprises about 0.05% to about 10% by weight of the backing layer.  
   
   
       18 . The device of  claim 17 , wherein the at least one colorizing compound comprises about 0.1% to about 5% by weight of the backing layer.  
   
   
       19 . The device of  claim 11 , wherein the backing layer comprises multiple colors.  
   
   
       20 . The device of  claim 19 , wherein the multiple colors comprise a pattern.  
   
   
       21 . The device of  claim 11 , wherein the backing layer further comprises glitter particles.  
   
   
       22 . The device of  claim 1 , wherein the backing layer is embedded or decorated with decorative items.  
   
   
       23 . The device of  claim 11 , wherein the backing layer is embedded or decorated with decorative items.  
   
   
       24 . The device of  claim 1 , wherein the backing layer displays letters, words, or images.  
   
   
       25 . The device of  claim 11 , wherein the backing layer displays letters, words, or images.  
   
   
       26 . The device of  claim 1 , wherein the binding material is selected from a group consisting of a polyolefin; polyester; polyurethane; polyamide; polyaramide; and glass.  
   
   
       27 . The device of  claim 26 , wherein the binding material comprises a polypropylene.  
   
   
       28 . The device of  claim 27 , wherein the binding material comprises a spun bonded polypropylene.  
   
   
       29 . The device of  claim 1 , wherein the binding material is from about 0.089 mm to about 0.279 mm thick.  
   
   
       30 . The device of  claim 29 , wherein the binding material is from about 0.114 mm to about 0.203 mm thick.  
   
   
       31 . The device of  claim 30 , wherein the binding material is about 0.152 mm thick.  
   
   
       32 . The device of  claim 1 , wherein the binding material is colored.  
   
   
       33 . The device of  claim 32  wherein the binding material is colored with at least one colorizing compound.  
   
   
       34 . The device of  claim 33  wherein the at least one colorizing compound is selected from the group consisting of FD&C Red No. 3; Food Red 17; Food Yellow 13; FD&C Yellow No. 5; FD&C Yellow No. 6; FD&C Green No. 3; FD&C Blue No. 1; FD&C Blue No. 2; FD&C Red No. 40; Orange B; Citrus Red No. 2; and combinations thereof.  
   
   
       35 . The device of  claim 33  wherein the at least one colorizing compound is selected from the group consisting of annatto extract; beta-apo-8′-carotenal; beta-carotene; beet powder; canthaxanthin; caramel color; carrot oil; cochineal extract (carmine); toasted, partially defatted, cooked cottonseed flour; ferrous gluconate; fruit juice; grape color extract; grape skin extract (enocianina); paprika; paprika oleoresin; riboflavin; saffron; turmeric; turmeric oleoresin; vegetable juice; and combinations thereof.  
   
   
       36 . The device of  claim 33  wherein the at least one colorizing compound is selected from the group consisting of titanium dioxide; chromium oxide greens; ultramarine blues and pinks; and ferric oxides.  
   
   
       37 . The device of  claim 33 , wherein the dye comprises a dye-lake form.  
   
   
       38 . The device of  claim 37 , wherein the dye-lake form is selected from the group consisting of FD&C Green #1 lake; FD&C Blue #2 lake; FD&C R&D #30 lake; and FD&C Yellow #15 lake.  
   
   
       39 . The device of  claim 33 , wherein the colorizing compound comprises about 0.05 percent to about 10 percent by weight of the binding material.  
   
   
       40 . The device of  claim 39 , wherein the colorizing compound comprises about 0.1 percent to about 5 percent by weight of the binding material.  
   
   
       41 . The device of  claim 33 , wherein the binding material comprises multiple colors.  
   
   
       42 . The device of  claim 1 , wherein the oral care layer is from about 0.025 mm to about 4 mm thick.  
   
   
       43 . The device of  claim 42 , wherein the oral care layer is from about 0.125 mm to about 1.5 mm thick.  
   
   
       44 . The device of  claim 43 , wherein the oral care layer is from about 0.25 mm to about 1.0 mm thick.  
   
   
       45 . The device of  claim 44 , wherein the oral care layer is about 0.3 mm thick.  
   
   
       46 . The device of  claim 1 , wherein the adhesiveness of the oral care layer with respect to the surface of the user's teeth is from about 200 N/m to about 400 N/m.  
   
   
       47 . The device of  claim 1 , wherein the at least one oral care agent is entrapped within the oral care layer.  
   
   
       48 . The device of  claim 47 , wherein the at least one oral care agent is released from the hydrophilic polymer upon hydration of the oral care layer.  
   
   
       49 . The device of  claim 1 , wherein the at least one oral care agent is activated upon hydration of the oral care layer.  
   
   
       50 . The device of  claim 1  wherein the oral care layer comprises a pressure-sensitive adhesive comprising at least one oral care agent, at least one hydrophilic polymer, and at least one water-soluble plasticizer that is miscible with the hydrophilic polymer.  
   
   
       51 . The device of  claim 50  wherein the at least one hydrophilic polymer has a hydrophilicity as measured by water uptake of greater than about 25%.  
   
   
       52 . The device of  claim 51  wherein the at least one hydrophilic polymer has a glass transition temperature T(g) or melting point T(m) higher than about 25° C. and lower than about 120° C.  
   
   
       53 . The device of  claim 52 , wherein the at least one hydrophilic polymer has a glass transition temperature T(g) or melting point T(m) higher than about 30° C. and lower than about 100° C.  
   
   
       54 . The device of  claim 50  wherein the at least one hydrophilic polymer is selected from the group consisting of polysaccharides; water-soluble synthetic polymers; polypeptides; and natural gums.  
   
   
       55 . The device of  claim 50  wherein the at least one hydrophilic polymer is selected from the group consisting of starches and starch derivatives; polyvinyl pyrrolidone; polyvinyl alcohol; hydroxypropyl cellulose; sodium carboxymethyl cellulose; polyethylene oxide; polyacrylic acid; polyacrylates; carboxylic acid polymers; xanthan gum; karaya gum; and gelatin.  
   
   
       56 . The device of  claim 50  wherein the at least one plasticizer is liquid at room temperature and has a boiling point higher than about 80° C.  
   
   
       57 . The device of  claim 56  wherein the at least one plasticizer is selected from the group consisting of glycerins; sorbitol; glycols; polysorbate 80; triethyl titrate; acetyl triethyl titrate; and tributyl titrate.  
   
   
       58 . The device of  claim 50 , wherein the oral care layer comprises at least one crosslinked or non-crosslinked polymer selected from the group consisting of 2-acrylamido-2-methyl-propanesulfonic acid; polyvinyl pyrrolidone; polyethylene oxide; acrylates; polyvinyl alcohol; and carboxylic acid polymers.  
   
   
       59 . The device of  claim 58 , wherein the oral care layer comprises crosslinked or non-crosslinked 2-acrylamido-2-methyl-propanesulfonic acid.  
   
   
       60 . The device of  claim 58 , wherein the oral care layer comprises crosslinked or non-crosslinked polyvinyl pyrrolidone.  
   
   
       61 . The device of  claim 1 , wherein the oral care layer is a sustained release oral care layer.  
   
   
       62 . The device of  claim 50 , wherein the oral care layer is a sustained release oral care layer.  
   
   
       63 . The device of  claim 60 , wherein the oral care layer is a sustained release oral care layer.  
   
   
       64 . The device of  claim 63  wherein the sustained-release oral care layer releases the at least one oral care agent at a rate of approximately 0.2 mg/cm 2 -min to 1 mg/cm 2 -min.  
   
   
       65 . The device of  claim 1 , wherein the amount of the at least one oral care agent in the oral care layer is about 0.01% to about 40%.  
   
   
       66 . The device of  claim 65 , wherein the amount of the at least one oral care agent in the oral care layer is about 0.1% to about 20%.  
   
   
       67 . The device of  claim 66 , wherein the amount of the at least one oral care agent in the oral care layer is about 0.5% to about 14%.  
   
   
       68 . The device of  claim 67 , wherein the amount of the at least one oral care agent in the oral care layer is about 1% to about 10%.  
   
   
       69 . The device of  claim 1 , wherein the at least one oral care agent is a pharmaceutically active agent or a cosmetically active agent.  
   
   
       70 . The device of  claim 69 , wherein the pharmaceutically active agent is selected from the group consisting of a non-steroidal anti-inflammatory/analgesic; a steroidal anti-inflammatory agent; a local anesthetic; a bactericide/disinfectant; an antibiotic; an antifungal; a tooth desensitizing agent; a fluoride anticavity/antidecay agent; an anti-tartar/anti-calculus agent; an enzyme which inhibits the formation of plaque, calculus or dental caries; and a nutritional supplement for local delivery to the teeth and surrounding tissue.  
   
   
       71 . The device of  claim 70 , wherein the non-steroidal anti-inflammatory/analgesic agent is selected from the group consisting of acetaminophen; methyl salicylate; monoglycol salicylate; aspirin; mefenamic acid; flufenamic acid; indomethacin; diclofenac; alclofenac; diclofenac sodium; ibuprofen; flurbiprofen; fentizac; bufexamac; piroxicam; phenylbutazone; oxyphenbutazone; clofezone; pentazocine; mepirizole; and tiaramide hydrochloride.  
   
   
       72 . The device of  claim 70 , wherein the steroidal anti-inflammatory agent is selected from the group consisting of hydrocortisone; prednisolone; dexamethasone; triamcinolone acetonide; fluocinolone acetonide; hydrocortisone acetate; prednisolone acetate; methylprednisolone; dexamethasone acetate; betamethasone; betamethasone valerate; flumetasone; flourometholone; budesonide; and beclomethasone dipropionate.  
   
   
       73 . The device of  claim 70 , wherein the local anesthetic is selected from the group consisting of dibucaine hydrochloride; dibucaine; lidocaine hydrochloride; lidocaine; benzocaine; p-buthylaminobenzoic acid 2-(diethylamino) ethyl ester hydrochloride; procaine hydrochloride; tetracaine hydrochloride; chloroprocaine hydrochloride; oxyprocaine hydrochloride; mepivacaine; cocaine hydrochloride; and piperocaine hydrochloride.  
   
   
       74 . The device of  claim 70 , wherein the bactericide/disinfectant is selected from the group consisting of thimerosol; phenol; thymol; benzalkonium chloride; benzethonium chloride; chlorhexidine; providone iodide; cetylpyridinium chloride; eugenol, and trimethylammonium bromide.  
   
   
       75 . The device of  claim 70 , wherein the antibiotic is selected from the group consisting of penicillin; meticillin; oxacillin; cefalotin; cefaloridin; erythromycin; lincomycin; tetracycline; chlortetracycline; oxytetracycline; metacycline; chloramphenicol; kanamycin; streptomycin; gentamicin; bacitracin; and cycloserine.  
   
   
       76 . The device of  claim 70 , wherein the antifungal drug is selected from the group consisting of amphotericin; clotrimazole; econazole nitrate; fluconazole; griseofulvin; itraconazole; ketoconazole; miconazole; nystatin; terbinafine hydrochloride; undecenoic acid; and zinc undecenoate.  
   
   
       77 . The device of  claim 70 , wherein the tooth-desensitizing agent is selected from the group consisting of potassium nitrate and strontium chloride.  
   
   
       78 . The device of  claim 70 , wherein the fluoride anticavity/antidecay agent is selected from the group consisting of sodium fluoride, potassium fluoride and ammonium fluoride.  
   
   
       79 . The device of  claim 70 , wherein the anti-tartar/anti-calculus agents is selected from the group consisting of phosphates; pyrophosphates, polyphosphates, polyphosphonates; linear carboxylic acids; sodium zinc citrate; and mixtures thereof.  
   
   
       80 . The device of  claim 70 , wherein the enzyme which inhibits the formation of plaque, calculus or dental caries is selected from the group consisting of proteases; lipases; dextranases, glucanohydrolases, endoglycosidases, mucinases; amylases; and mixtures thereof.  
   
   
       81 . The device of  claim 70 , wherein the nutritional supplement for local delivery to the teeth and surrounding tissue is a vitamin or mineral.  
   
   
       82 . The device of  claim 81 , wherein the nutritional supplement for local delivery to the teeth and surrounding tissue is a vitamin selected from the group consisting of vitamin C; vitamin D; thiamine; riboflavin; calcium pantothenate; niacin; folic acid; nicotinamide; pyridoxine; cyanocobalamin; para-aminobenzoic acid; bioflavonoids; and mixtures thereof.  
   
   
       83 . The device of  claim 81 , wherein the nutritional supplement for local delivery to the teeth and surrounding tissue is a mineral selected from the group consisting of calcium; phosphorus; fluoride; zinc; manganese; potassium; and mixtures thereof.  
   
   
       84 . The device of  claim 69 , wherein the cosmetically active agent is selected from the group consisting of a breath freshener; a tooth whitening agent; and a tooth coloring or tinting agent.  
   
   
       85 . The device of  claim 84 , wherein the tooth whitening agent is selected from the group consisting of peroxides; metal chlorites; perborates; percarbonates; peroxyacids; and combinations thereof.  
   
   
       86 . The device of  claim 85 , wherein the tooth whitening agent is a peroxide selected from the group consisting of hydrogen peroxide; calcium peroxide; carbamide peroxide; and mixtures thereof.  
   
   
       87 . The device of  claim 85 , wherein the tooth whitening agent is a metal chlorite selected from the group consisting of calcium chlorite; barium chlorite; magnesium chlorite; lithium chlorite; sodium chlorite; and potassium chlorite; hypochlorite and chlorine dioxide.  
   
   
       88 . The device of  claim 85 , wherein the concentration of tooth whitening agent in the oral care layer is about 0.01% to about 40%.  
   
   
       89 . The device of  claim 86 , wherein the peroxide compound in the oral care layer is equivalent to about 0.1% to about 20% hydrogen peroxide.  
   
   
       90 . The device of  claim 89 , wherein the peroxide compound in the oral care layer is equivalent to about 0.5% to about 13% hydrogen peroxide.  
   
   
       91 . The device of  claim 90 , wherein the peroxide compound in the oral care layer is equivalent to about 1% to about 10% hydrogen peroxide.  
   
   
       92 . The device of  claim 91 , wherein the peroxide compound in the oral care layer is equivalent to about 6-9% hydrogen peroxide.  
   
   
       93 . The device of  claim 86 , wherein the amount of hydrogen peroxide in the oral care layer is from about 0.1% to about 30%.  
   
   
       94 . The device of  claim 93 , wherein the amount of hydrogen peroxide in the oral care layer is from about 3% to about 20%.  
   
   
       95 . The device of  claim 94 , wherein the amount of hydrogen peroxide in the oral care layer is from about 6% to about 12%.  
   
   
       96 . The device of  claim 1 , wherein at least one layer further comprises a colorizing compound; food additive; flavorant; sweetener; or preservative.  
   
   
       97 . The device of  claim 96 , wherein the flavorant is selected from the group consisting of wintergreen; peppermint; spearmint; menthol; fruit flavors; vanilla; cinnamon; spices; flavor oils; oleoresins; and mixtures thereof.  
   
   
       98 . The device of  claim 96 , wherein the sweetener is selected from the group consisting of sucrose; fructose; aspartame; xylitol; and saccharine.  
   
   
       99 . The device of  claim 1 , wherein: 
 i) the backing layer comprises 50% microcrystalline wax, 15% paraffin wax; and 35% hydrocarbon resin;    ii) the binding material comprises a spun bonded polypropylene; and    iii) the oral care layer comprises 6-9% hydrogen peroxide, 30-40% polyvinylpyrrolidone K90, 7-15% polyethylene glycol 400; and 15-20% methacrylic acid-ethyl acrylate copolymer (1:1).    
   
   
       100 . The device of  claim 99 , wherein the backing layer is colored.  
   
   
       101 . The device of  claim 1 , further comprising a release liner or covering over the oral care layer.  
   
   
       102 . The device of  claim 1 , further comprising a scrim embedded in the oral care layer.  
   
   
       103 . The device of  claim 99 , further comprising a scrim embedded in the oral care layer.  
   
   
       104 . The device of  claim 103 , wherein the scrim comprises one or more of woven, non-woven or perforated sheetlike materials.  
   
   
       105 . The device of  claim 104 , wherein the woven materials of the scrim are selected from the group consisting of cotton; a polyolefin; polyester; polyurethane; polyamide; polyaramide; and glass.  
   
   
       106 . The device of  claim 104 , wherein the non-woven material of the scrim is selected from the group consisting of a polyolefin; polyester; polyurethane; polyamide; polyaramide; and glass.  
   
   
       107 . The device of  claim 104 , wherein the perforated material of the scrim comprises fine pitch polypropylene net.  
   
   
       108 . The device of  claim 102 , wherein the scrim comprises a non-woven polyolefin.  
   
   
       109 . The device of  claim 103 , wherein the scrim comprises a non-woven polyolefin.  
   
   
       110 . The device of  claim 1  which has a “J”, “reversed J”, or “C” shape when viewed in cross-section.  
   
   
       111 . The device of  claim 1  which is sized to fit the primary, mixed or permanent dentition of a human being.  
   
   
       112 . The device of  claim 1  which is of sufficient length and width to cover the facial surface, crowns and at least partially cover the lingual surface of the incisors in an upper or lower dental arch of a human being.  
   
   
       113 . The device of  claim 1  which is of sufficient length and width to cover the facial surface, crowns and at least partially cover the lingual surface of the anterior teeth in an upper or lower dental arch of a human being.  
   
   
       114 . The device of  claim 1  which is of sufficient length and width to cover the facial surface, crowns and at least partially cover the lingual surface of the anterior and posterior teeth in an upper or lower dental arch of a human being.  
   
   
       115 . The device of  claim 1  designed to fit the upper dental arch of a human being, wherein the device is about 7 cm to about 9 cm in length, and about 0.8 cm to about 2.5 cm in width.  
   
   
       116 . The device of  claim 1  designed to fit the lower dental arch of a human being, wherein the device is about 4 cm to about 6 cm in length, and about 1 cm to about 2 cm in width.  
   
   
       117 . The device of  claim 1 , wherein the device, when viewed in plan view, is bent into an essentially horseshoe shape that generally matches the catenary arch of a human being.  
   
   
       118 . The device of  claim 1  further comprising one or more notches.  
   
   
       119 . The device of  claim 1 , wherein the device is substantially non-flat.  
   
   
       120 . A method for delivering an oral care agent to the teeth in an upper or lower dental arch in a subject, which teeth are in need of treatment, comprising: 
 1) providing the device of  claim 1;     2) wetting the teeth or the oral care layer of the device;    3) placing the device over the teeth of a dental arch which are in need of treatment, and    4) conforming the device to the teeth and surrounding tissue by manual pressure so that the oral care layer is in contact with at least the facial surface of the teeth to be treated.    
   
   
       121 . The method of  claim 120 , wherein the treatment comprises the treatment of an undesirable physiological condition.  
   
   
       122 . The method of  claim 121 , wherein the undesirable physiological condition is selected from the group consisting of halitosis; periodontal and oral infections; periodontal lesions; dental caries or decay; and gingivitis.  
   
   
       123 . The method of  claim 120 , wherein the oral care layer comprises a pressure-sensitive adhesive comprising at least one oral care agent, at least one hydrophilic polymer, and at least one water-soluble plasticizer that is miscible with the hydrophilic polymer.  
   
   
       124 . The method of  claim 123 , wherein the at least one hydrophilic polymer has a hydrophilicity as measured by water uptake of greater than about 25%.  
   
   
       125 . The method of  claim 124 , wherein the at least one hydrophilic polymer has a glass transition temperature T(g) or melting point T(m) higher than about 25° C. and lower than about 120° C.  
   
   
       126 . The method of  claim 125 , wherein the oral care layer comprises at least one crosslinked or non-crosslinked polymer selected from the group consisting of 2-acrylamido-2-methyl-propanesulfonic acid; polyvinyl pyrrolidone; polyethylene oxide; acrylates; polyvinyl alcohol; and carboxylic acid polymers.  
   
   
       127 . The method of  claim 126 , wherein the oral care layer comprises crosslinked or non-crosslinked 2-acrylamido-2-methyl-propanesulfonic acid.  
   
   
       128 . The method of  claim 126 , wherein the oral care layer comprises crosslinked or non-crosslinked polyvinyl pyrrolidone.  
   
   
       129 . The method of  claim 120 , wherein the oral care layer is a sustained release oral care layer.  
   
   
       130 . The method of  claim 128 , wherein the oral care layer is a sustained release oral care layer.  
   
   
       131 . The method of  claim 130 , wherein the sustained-release oral care layer releases the at least one oral care agent at a rate of approximately 0.2 mg/cm 2  -min to 1 mg/cm 2 -min.  
   
   
       132 . The method of  claim 120 , wherein the treatment comprises a cosmetic treatment.  
   
   
       133 . The method of  claim 120 , wherein the device is left on the teeth for about 15 minutes to about 4 hours.  
   
   
       134 . The method of  claim 133 , wherein the device is left on the teeth for about 30 minutes to about 1 hour.  
   
   
       135 . A method for delivering a tooth whitening agent to the teeth in an upper or lower dental arch in a subject comprising: 
 1) providing the device of  claim 1 , wherein the oral care agent is a tooth whitening agent;    2) wetting the teeth or the oral care layer of the device;    3) placing the device over the teeth of a dental arch, and    4) conforming the device to the teeth and surrounding tissue by manual pressure so that the oral care layer is in contact with at least the facial surface of the teeth.    
   
   
       136 . The method of  claim 135 , wherein the oral care layer comprises a pressure-sensitive adhesive comprising at least one tooth whitening agent, at least one hydrophilic polymer, and at least one water-soluble plasticizer that is miscible with the hydrophilic polymer.  
   
   
       137 . The method of  claim 136 , wherein the at least one hydrophilic polymer has a hydrophilicity as measured by water uptake greater than about 25%.  
   
   
       138 . The method of  claim 137 , wherein the at least one hydrophilic polymer has a glass transition temperature T(g) or melting point T(m) higher than about 25° C. and lower than about 120° C.  
   
   
       139 . The method of  claim 138 , wherein the oral care layer comprises at least one crosslinked or non-crosslinked polymer selected from the group consisting of 2-acrylamido-2-methyl-propanesulfonic acid; polyvinyl pyrrolidone; polyethylene oxide; acrylates; polyvinyl alcohol; and carboxylic acid polymers.  
   
   
       140 . The method of  claim 139 , wherein the oral care layer comprises crosslinked or non-crosslinked 2-acrylamido-2-methyl-propanesulfonic acid.  
   
   
       141 . The method of  claim 139 , wherein the oral care layer comprises crosslinked or non-crosslinked polyvinyl pyrrolidone.  
   
   
       142 . The method of  claim 135 , wherein the oral care layer is a sustained release oral care layer.  
   
   
       143 . The method of  claim 141 , wherein the oral care layer is a sustained release oral care layer.  
   
   
       144 . The method of  claim 143 , wherein the sustained-release oral care layer releases the at least one tooth whitening agent at a rate of approximately 0.2 mg/cm 2 -min to 1 mg/cm 2 -min.  
   
   
       145 . The method of  claim 135 , wherein the device is left on the teeth for about 15 minutes to about 4 hours.  
   
   
       146 . The method of  claim 135 , wherein the device is left on the teeth for about 30 minutes to about 1 hour.  
   
   
       147 . The method of  claim 135 , wherein the tooth whitening agent is selected from the group consisting of peroxides; metal chlorites; perborates; percarbonates; peroxyacids; and combinations thereof.  
   
   
       148 . The method of  claim 147 , wherein the tooth whitening agent is a peroxide selected from the group consisting of hydrogen peroxide; calcium peroxide; carbamide peroxide; and mixtures thereof.  
   
   
       149 . The method of  claim 147 , wherein the tooth whitening agent is a metal chlorite selected from the group consisting of calcium chlorite; barium chlorite; magnesium chlorite; lithium chlorite; sodium chlorite; and potassium chlorite; hypochlorite and chlorine dioxide.  
   
   
       150 . The method of  claim 135 , wherein the concentration of tooth whitening agent in the oral care layer is about 0.01% to about 40%.  
   
   
       151 . The method of  claim 148 , wherein the peroxide compound in the oral care layer provides an amount of peroxide equivalent to about 0.1% to about 20% of hydrogen peroxide.  
   
   
       152 . The method of  claim 148 , wherein the peroxide compound in the oral care layer provides an amount of peroxide equivalent to about 0.5% to about 13% of hydrogen peroxide.  
   
   
       153 . The method of  claim 148 , wherein the peroxide compound in the oral care layer provides an amount of peroxide equivalent to about 1% to about 10% of hydrogen peroxide.  
   
   
       154 . The method of  claim 148 , wherein the peroxide compound in the oral care layer provides an amount of peroxide equivalent to about 6% of hydrogen peroxide.  
   
   
       155 . The method of  claim 148 , wherein the amount of hydrogen peroxide in the oral care layer is from about 0.1% to about 30%.  
   
   
       156 . The method of  claim 148 , wherein the amount of hydrogen peroxide in the oral care layer is from about 3% to about 20%.  
   
   
       157 . The method of  claim 148 , wherein the amount of hydrogen peroxide in the oral care layer is from about 6% to about 12%.  
   
   
       158 . A method of making the device of  claim 1 , comprising the steps of: 
 1) providing a permanently deformable backing layer, an oral care layer, and a non-woven binding material, wherein the binding material comprises a first part and a second part;    2) integrally coupling at least a portion of the backing layer with the second part of the binding material;    3) extruding an oral care layer onto the first part of the binding material such that at least a portion of the oral care layer is integrally coupled with the first part of the binding material.    
   
   
       159 . The method of  claim 158 , in which an aqueous solution of the oral care agent is printed onto the binding material prior to extruding the oral care layer onto the binding material.  
   
   
       160 . The method of  claim 158 , further comprising placing a scrim on the binding material before extruding the oral care layer onto the binding material.  
   
   
       161 . The method of  claim 160 , wherein the scrim comprises a non-woven polyolefin.