Novel anticonvulsant derivative salts

Abstract

The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the treatment of epilepsy.

1 . A salt of a compound of formula (I)  
     
       
         
         
             
             
         
       
       wherein the salt of the compound of formula (I) is formed at the sulfamate groups and wherein the salt is selected from the group consisting of magnesium and lithium.  
     
   
   
       2 . A salt as in  claim 1 , wherein the compound of formula (I) is topiramate.  
   
   
       3 . A salt as in  claim 1 , wherein a lithium or magnesium cation displaces one hydrogen atom of the sulfamate.  
   
   
       4 - 15 . (canceled)  
   
   
       16 . A salt as in  claim 1 , wherein the salt of the compound of formula (I) is a lithium salt of topiramate.  
   
   
       17 . A salt as in  claim 16 , of the formula (IV)  
     
       
         
         
             
             
         
       
     
   
   
       18 . A salt as in  claim 1 , wherein the salt of the compound of formula (I) is a magnesium salt of topiramate.  
   
   
       19 . A salt as in  claim 18 , of the formula (V)  
     
       
         
         
             
             
         
       
     
   
   
       20 . A pharmaceutical composition comprising a salt of  claim 1  and a pharmaceutically acceptable carrier.  
   
   
       21 . A pharmaceutical composition prepared by combining a salt of  claim 1  and a pharmaceutically acceptable carrier.  
   
   
       22 . A process for making a pharmaceutical composition comprising combining a salt of  claim 1  with a pharmaceutically acceptable carrier.  
   
   
       23 - 25 . (canceled)  
   
   
       26 . A process for preparing a lithium salt of a compound of formula (I) comprising 
 reacting a compound of formula (I)                          with lithium hydride under anhydrous conditions, lithium hydroxide, lithium lower alkoxide, alkyl lithium under anhydrous conditions or lithium amide under anhydrous conditions, in an organic solvent; and precipitating the product.    
   
   
       27 . A process for preparing a magnesium salt of a compound of formula (I) comprising 
 reacting a compound of formula (I)                          with a magnesium lower alkoxide, under anhydrous conditions, in an organic solvent; and precipitating the product.    
   
   
       28 - 30 . (canceled)  
   
   
       31 . A process as in  claim 26 , wherein the compound of formula (I) is topiramate.  
   
   
       32 . A process as in  claim 27 , wherein the compound of formula (I) is topiramate.