US2006106116A1PendingUtilityA1

Composition for lessening oxidative stress

Assignee: KANEKA CORPPriority: Oct 12, 2001Filed: Dec 23, 2005Published: May 18, 2006
Est. expiryOct 12, 2021(expired)· nominal 20-yr term from priority
A61P 43/00A61K 31/085A61K 31/122A61P 39/06
51
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Claims

Abstract

A method for lessening oxidative stress in vivo in a subject in need thereof, comprising administering to said subject a composition containing a reduced coenzyme Q and an oxidized coenzyme of Q.

Claims

exact text as granted — not AI-modified
1 . A method for lessening oxidative stress in vivo in a subject in need thereof, comprising administering to said subject a composition containing a reduced coenzyme Q of formula (2) and an oxidized coenzyme Q of formula (1):  
     
       
         
         
             
             
         
       
     
     (wherein n represents an integer from 1 to 12);  
     
       
         
         
             
             
         
       
     
     (wherein n represents an integer from 1 to 12).  
   
   
       2 . The method according to  claim 1 , wherein the coenzyme Q is coenzyme Q 10 .  
   
   
       3 . A method of reducing oxidative stress in viva associated with a disease comprising administering to a subject a composition containing a reduced coenzyme Q antioxidant of formula (2) and an oxidized coenzyme Q of formula (1):  
     
       
         
         
             
             
         
       
     
     (wherein n represents an integer from 1 to 12);  
     
       
         
         
             
             
         
       
     
     (wherein n represents an integer from 1 to 12).  
   
   
       4 . The method according to  claim 2 , wherein the coenzyme Q is coenzyme Q 10 .  
   
   
       5 . A method according to  claim 2 , wherein the reduced and oxidized coenzyme Q are administered to a human in a total dose per kg of weight of a human body of 0.1 mg/day to 500 mg/day.  
   
   
       6 . A method according to  claim 2 , wherein the reduced and oxidized coenzyme Q are administered to a human in a total dose per kg of weight of a human body of 1 mg/day to 100 mg/day.  
   
   
       7 . A method according to  claim 2 , wherein the reduced and oxidized coenzyme Q are administered to a human in a total dose per kg of weight of a human body of 2 mg/day to 75 mg/day.  
   
   
       8 . A method for reducing oxidative stress in vivo due to a skin disease comprising externally administering to a subject a composition containing a reduced coenzyme Q of formula (2) and an oxidized coenzyme Q of formula (1):  
     
       
         
         
             
             
         
       
     
     (wherein n represents an integer from 1 to 12);  
     
       
         
         
             
             
         
       
       (wherein n represents an integer from 1 to 12).  
     
   
   
       9 . The method according to  claim 8 , wherein the coenzyme Q is coenzyme Q 10 .  
   
   
       10 . A method for lessening oxidative stress in vivo in a subject in need thereof, comprising administering to said subject a composition containing a reduced coenzyme Q of formula (2):  
     
       
         
         
             
             
         
       
       (wherein n represents an integer from 1 to 12).  
     
   
   
       11 . The method according to  claim 10 , wherein the coenzyme Q is coenzyme Q 10 .  
   
   
       12 . A method for reducing oxidative stress in vivo due to a disease comprising administering to a subject a composition containing a reduced coenzyme Q antioxidant of formula (2):  
     
       
         
         
             
             
         
       
       (wherein n represents an integer from 1 to 12).  
     
   
   
       13 . The method according to  claim 12 , wherein the coenzyme Q is coenzyme Q 10 .  
   
   
       14 . A method according to  claim 12 , wherein the reduced coenzyme Q is administered to a human in dose per kg of weight of a human body of 0.1 mg/day to 500 mg/day.  
   
   
       15 . A method according to  claim 12 , wherein the reduced coenzyme Q is administered to a human in dose per kg of weight of a human body of 1 mg/day to 100 mg/day.  
   
   
       16 . A method according to  claim 12 , wherein the reduced coenzyme Q is administered to a human in dose per kg of weight of a human body of 2 mg/day to 75 mg/day.  
   
   
       17 . A method for treating reducing oxidative stress in vivo due to a skin disease comprising externally administering to a subject a composition containing a reduced coenzyme Q of formula (2):  
     
       
         
         
             
             
         
       
       (wherein n represents an integer from 1 to 12).  
     
   
   
       18 . The method according to  claim 17 , wherein the coenzyme Q is coenzyme Q 10 .

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