Remedy and preventive for diseases caused by NF-kB

Abstract

Administration of a decoy, i.e. a compound which specifically antagonizes the nucleic acid domain to which NF-κB is bound, is effective in the treatment and prevention of diseases caused by the transcriptional regulatory factor NF-κB, such as ischemic diseases, inflammatory diseases, autoimmune diseases, cancer metastasis and invasion, and cachexia.

1 . An NF-κB double-stranded decoy oligonucleotide, comprising a sense and an anti-sense strand, wherein the sequence comprises, in the 5′ to 3′ direction, SEQ ID NO: 1.  
     
     
         2 . An NF-κB double-stranded decoy oligonucleotide, comprising a sense and an anti-sense strand, wherein a strand consists of, in the 5′ to 3′ direction, SEQ ID NO: 1.