1H-pyrazole and 1h-pyrole-azabicyclic compounds for the treatment of disease

Abstract

The invention provides compounds of Formula I: wherein Azabicyclo is W is where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat a disease or condition in which α7 is known to be involved.

1 . A compound of the Formula I:  
     
       
         
         
             
             
         
       
     
     wherein Azabicyclo is  
     
       
         
         
             
             
         
       
     
     W is  
     
       
         
         
             
             
         
       
     
     wherein W 1  is N or CH; 
 X is O or S;  
 R 0  is H, lower alkyl, substituted lower alkyl, or halogenated lower alkyl;  
 R 1  is H, alkyl, halogenated alkyl, cycloalkyl, substituted phenyl, or substituted naphthyl;  
 R 2  is F, Cl, Br, I, alkyl, halogenated alkyl, substituted alkyl, cycloalkyl, or aryl;  
 k 1 , k 2 , k 5 , k 6 , and k 7  are independently 0, or 1;  
 k 3 , and k 4  are independently 0, 1, or 2;  
 Each R 3  is independently F, Cl, Br, I, —CN, —NO 2 , alkyl, halogenated alkyl, substituted alkyl, alkenyl, halogenated alkenyl, substituted alkenyl, alkynyl, halogenated alkynyl, substituted alkynyl, cycloalkyl, halogenated cycloalkyl, substituted cycloalkyl, heterocycloalkyl, halogenated heterocyloalkyl, substituted heterocycloalkyl, lactam heterocyclcoalkyl, aryl, R 7 , R 9 , —OR 10 , —SR 10 , —SOR 10 , —SO 2 R 10 , —SCN, —S(O)N(R 10 ) 2 , —S(O) 2 N(R 10 ) 2 , —C(O)R 10 , —C(O) 2 R 10 , —C(O)N(R 10 ) 2 , C(R 10 )═N—OR 10 , —NC(O)R 7 , —NC(O)R 8 , —NC(O)R 9 , —N(R 10 ) 2 , —NR 10 C(O)R 10 , —NR 10 S(O) 2 R 10 , or two R 3  on adjacent carbon atoms may fuse to form a 6-membered ring to give a 5-6 fused, bicyclic moiety where the 6-membered ring is optionally substituted with 1-3 substitutents selected from R 4 ;  
 m is 0, 1, or 2;  
 R 4  is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, halogenated alkyl, halogenated alkenyl, halogenated alkynyl, halogenated cycloalkyl, halogenated heterocycloalkyl, —OR 8 , —SR 8 , —S(O) 2 R 8 , —S(O)R 8 , —OS(O) 2 R 8 , —N(R 8 ) 2 , —C(O)R 8 , —C(S)R 8 , —C(O)OR 8 , —CN, —C(O)N(R 8 ) 2 , —NR 8 C(O)R 8 , —S(O) 2 N(R 8 ) 2 , —NR 8 S(O) 2 R 8 , —NO 2 , —N(R 8 )C(O)N(R 8 ) 2 , substituted alkyl, substituted alkenyl, substituted alkynyl, substituted cycloalkyl, substituted heterocycloalkyl, lactam heterocycloalkyl, phenyl, phenyl having 0-4 substituents independently selected from F, Cl, Br, I and R 15 , naphthyl, naphthyl having 0-4 substituents independently selected from F, Cl, Br, I, or R 15 , or two R 4  on adjacent carbon atoms may combine to form a three-ring-fused-5-6-6 system optionally substituted with up to 3 substituents independently selected from Br, Cl, F, I, —CN, —NO 2 , —CF 3 , —N(R 8 ) 2 , —N(R 8 )C(O)R 8 , alkyl, alkenyl, and alkynyl;  
 Each R 5  is independently H, alkyl, or substituted alkyl;  
 R 6  is H, alkyl, an amino protecting group, or an alkyl group having 1-3 substituents selected from F, Cl, Br, I, —OH, —CN, —NH 2 , —NH(alkyl), or —N(alkyl) 2 ;  
 R 7  is 5-membered heteroaromatic mono-cyclic moieties containing within the ring 1-3 heteroatoms independently selected from the group consisting of —O—, ═N—, —N(R 14 )—, and —S—, and having 0-1 substituent selected from R 15 , and further having 0-3 substituents independently selected from F, Cl, Br, or I, or R 7  is 9-membered fused-ring moieties having a 6-membered ring fused to a 5-membered ring and having the formula  
                     
 wherein A 1  is O, S, or NR 14 ,  
                     
 wherein A is CR 17  or N, and each A 2  or A 3  is independently selected from CR 17 , O, S, N, or NR 14 , or  
                     
 wherein A is CR 17  or N, and each A 2  or A 3  is independently selected from CR 17 , O, S, N, or NR 14 , and, each 9-membered fused-ring moiety having 0-1 substituent selected from R 15 , and further having 0-3 substituent(s) independently selected from F, Cl, Br, or I, and having a bond directly or indirectly attached to the core molecule where valency allows in either the 6-membered or the 5-membered ring of the fused-ring moiety;  
 Each R 8  is independently H, alkyl, halogenated alkyl, substituted alkyl, cycloalkyl, halogenated cycloalkyl, substituted cycloalkyl, heterocycloalkyl, halogenated heterocycloalkyl, substituted heterocycloalkyl, phenyl, or phenyl substituted with 0-4 independently selected from F, Cl, Br, I, or R 15 ;  
 R 9  is 6-membered heteroaromatic mono-cyclic moieties containing within the ring 1-3 heteroatoms selected from ═N— and having 0-1 substituent selected from R 15  and 0-3 substituent(s) independently selected from F, Cl, Br, or I, or R 9  is 10-membered heteroaromatic bi-cyclic moieties containing within one or both rings 1-3 heteroatoms selected from ═N—, including, but not limited to, quinolinyl or isoquinolinyl, each 10-membered fused-ring moiety having 0-1 substituent selected from R 15 , and 0-3 substituent(s) independently selected from F, Cl, Br, or I and having a bond directly or indirectly attached to the core molecule where valency allows;  
 Each R 10  is independently H, alkyl, cycloalkyl, heterocycloalkyl, alkyl substituted with 1 substituent selected from R 13 , cycloalkyl substituted with 1 substituent selected from R 13 , heterocycloalkyl substituted with 1 substituent selected from R 13 , halogenated alkyl, halogenated cycloalkyl, halogenated heterocycloalkyl, phenyl, or substituted phenyl;  
 Each R 11  is independently H, alkyl, cycloalkyl, heterocyclo-alkyl, halogenated alkyl, halogenated cycloalkyl, or halogenated heterocycloalkyl;  
 R 12  is —NO 2 , —CN, alkyl, cycloalkyl, heterocycloalkyl, halogenated alkyl, halogenated cycloalkyl, halogenated heterocycloalkyl, substituted alkyl, substituted cycloalkyl, substituted heterocycloalkyl, —OR 11 , —SR 11 , —N(R 11 ) 2 , —C(O)R 11 , —C(O)N(R 11 ) 2 , —NR 11 C(O)R 11 , —S(O) 2 N(R 11 ) 2 , or —NR 11 S(O) 2 R 11 ;  
 R 13  is —OR 11 , —SR 11 , —N(R 11 ) 2 , —C(O)R 11 , —SOR 11 , —SO 2 R 11 , —C(O)N(R 11 ) 2 , —CN, —CF 3 , —NR 11 C(O)R 11 , —S(O) 2 N(R 11 ) 2 , —NR 11 S(O) 2 R 11 , or —NO 2 ;  
 R 14  is independently H, alkyl, halogenated alkyl, limited substituted alkyl, cycloalkyl, halogenated cycloalkyl, substituted cycloalkyl, heterocycloalkyl, halogenated heterocycloalkyl, or substituted heterocycloalkyl;  
 R 15  is alkyl, substituted alkyl, halogenated alkyl, —OR 11 , —CN, —NO 2 , —N(R 10 ) 2 ;  
 R 17  is H, alkyl, cycloalkyl, heterocycloalkyl, halogenated alkyl, halogenated cycloalkyl, halogenated heterocycloalkyl, R 18 , —OR 11 , —SR 11 , —N(R 11 ) 2 , —NR 11 S(O) 2 R 11 , F, Cl, Br, or I, or a bond directly or indirectly attached to the core molecule, provided that there is only one said bond to the core molecule within the 9-membered fused-ring moiety, further provided that the fused-ring moiety has 0-1 substituent selected from alkyl, cycloalkyl, heterocycloalkyl, halogenated alkyl, halogenated cycloalkyl, halogenated heterocycloalkyl, R 18 , —OR 11 , —SR 11 , —NR 11 R 11 , —C(O)R 11 , —NO 2 , —C(O)NR 11 R 11 , —CN, —NR 11 C(O)R 1 , —S(O) 2 NR 11 R 11 , or —NR 11 S(O) 2 R 11 , and further provided that the fused-ring moiety has 0-3 substituent(s) selected from F, Cl, Br, or I;  
 R 18  is alkyl, cycloalkyl, heterocycloalkyl, any of which is substituted with 0-3 substituents independently selected from F, Cl, Br, or I and further substituted with 1 substituent selected from —NO 2 , —CN, —OR 10 , —SR 10 , —NR 10 R 10 , —C(O)R 10 , —C(O)NR 10 R 10 , —NR 10 C(O)R 10 , —S(O) 2 NR 10 R 10 , —NR 10 S(O) 2 R 10 , phenyl, or phenyl having 1 substituent selected from R 15  and further having 0-3 substituents independently selected from F, Cl, Br, or I;  
 or pharmaceutically acceptable salt, racemic mixture, or pure enantiomer thereof.  
 
   
   
       2 . The compound of  claim 1 , wherein X is O.  
   
   
       3 . The compound of  claim 2 , wherein R 0  is H, lower alkyl, substituted lower alkyl, or halogenated lower alkyl, wherein R 1  is H, alkyl, or cycloalkyl, and wherein k 1 , k 2 , k 3  and k 4  are each 0 or 1, provided that when k 1 , k 2 , k 3  or k 4  is 1, each R 2  is independently lower alkyl, substituted lower alkyl, or halogenated lower alkyl.  
   
   
       4 . The compound of  claim 3 , wherein m is 0 or 1.  
   
   
       5 . The compound of  claim 4 , wherein Azabicyclo is I, II, III, or IV.  
   
   
       6 . The compound of  claim 5 , where R 2  is lower alkyl, provided that k 1 , k 2 , k 3  or k 4  is 1, or k l , k 2 , k 3  and k 4  is 0.  
   
   
       7 . The compound of  claim 6 , wherein W 1  is N.  
   
   
       8 . The compound of  claim 7 , wherein the compound is 
 N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-chloro-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-bromo-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-iodo-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-methyl-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-cyano-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-(methylthio)-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-thien-2-yl-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-thien-3-yl-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-pyridin-2-yl-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-pyridin-3-yl-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-phenyl-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-(2-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-(3-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-(4-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-(2-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-(3-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-(4-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-(2-methylphenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-(3-methylphenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-(4-methylphenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-(2-methoxyphenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-(3-methoxyphenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-(4-methoxyphenyl)-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-chloro-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-bromo-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-iodo-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-methyl-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-cyano-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(methylthio)-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-thien-2-yl-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-4-thien-3-yl-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-pyridin-2-yl-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-pyridin-3-yl-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-phenyl-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(2-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(3-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(4-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-4-(2-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(3-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(4-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(2-methylphenyl)-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(3-methylphenyl)-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(4-methylphenyl)-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(2-methoxyphenyl)-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(3-methoxyphenyl)-1H-pyrazole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(4-methoxyphenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-chloro-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-bromo-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-iodo-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-methyl-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-cyano-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(methylthio)-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-thien-2-yl-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-thien-3-yl-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-pyridin-2-yl-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-pyridin-3-yl-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-phenyl-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(2-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(3-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(4-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(2-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(3-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(4-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(2-methylphenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(3-methylphenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(4-methylphenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(2-methoxyphenyl)-1H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(3-methoxyphenyl)-H-pyrazole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]4-(4-methoxyphenyl)-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-chloro-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-bromo-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2. I]hept-3-yl)-4-iodo-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-methyl-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-cyano-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-(methylthio)-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-thien-2-yl-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-thien-3-yl-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-pyridin-2-yl-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-pyridin-3-yl-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-phenyl-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-(2-fluorophenyl)-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-(3-fluorophenyl)-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-(4-fluorophenyl)-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-(2-chlorophenyl)-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-(3-chlorophenyl)-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-(4-chlorophenyl)-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-(2-methylphenyl)-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-(3-methylphenyl)-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-(4-methylphenyl)-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-(2-methoxyphenyl)-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-(3-methoxyphenyl)-1H-pyrazole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-4-(4-methoxyphenyl)-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-chloro-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-bromo-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-iodo-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-methyl-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-cyano-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-(methylthio)-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-thien-2-yl-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-thien-3-yl-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-pyridin-2-yl-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-pyridin-3-yl-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-phenyl-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-(2-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-(3-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-(4-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-(2-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-(3-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-(4-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-(2-methylphenyl)-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-(3-methylphenyl)-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-(4-methylphenyl)-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-(2-methoxyphenyl)-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-(3-methoxyphenyl)-1H-pyrazole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-4-(4-methoxyphenyl)-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-chloro-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-bromo-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-iodo-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-methyl-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-cyano-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-(methylthio)-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-thien-2-yl-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-thien-3-yl-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-pyridin-2-yl-1H-pyrazole-1-carboxamide;    N−1-azabicyclo[3.2.2]non-3-yl-4-pyridin-3-yl-1H-pyrazole-1-carboxamide;    N−1-azabicyclo[3.2.2]non-3-yl-4-phenyl-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-(2-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-(3-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-(4-fluorophenyl)-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-(2-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-(3-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-(4-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-(2-methylphenyl)-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-(3-methylphenyl)-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-(4-methylphenyl)-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-(2-methoxyphenyl)-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-(3-methoxyphenyl)-1H-pyrazole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-4-(4-methoxyphenyl)-1H-pyrazole-1-carboxamide; or    a pharmaceutically acceptable salt thereof.    
   
   
       9 . The compound of  claim 8 , wherein the compound is 
 N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-bromo-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-iodo-1H-pyrazole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]4-(2-chlorophenyl)-1H-pyrazole-1-carboxamide;    N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]4-iodo-1H-pyrazole-1-carboxamide; or    pharmaceutically acceptable salt thereof.    
   
   
       10 . The compound of  claim 6 , wherein W 1  is CH.  
   
   
       11 . The compound of  claim 9 , wherein the compound is 
 N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-chloro-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-bromo-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-iodo-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-methyl-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-cyano-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-(methylthio)-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-thien-2-yl-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-thien-3-yl-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-pyridin-2-yl-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-pyridin-3-yl-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-phenyl-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-(2-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-(3-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-(4-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-(2-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-(3-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-(4-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-(2-methylphenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-(3-methylphenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-(4-methylphenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-(2-methoxyphenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-(3-methoxyphenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-(4-methoxyphenyl)-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-chloro-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-bromo-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-iodo-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-methyl-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-cyano-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(methylthio)-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-thien-2-yl-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-thien-3-yl-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-pyridin-2-yl-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-pyridin-3-yl-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-phenyl-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(2-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(3-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(4-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(2-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(3-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(4-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(2-methylphenyl)-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(3-methylphenyl)-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(4-methylphenyl)-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(2-methoxyphenyl)-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(3-methoxyphenyl)-1H-pyrrole-1-carboxamide;    N-[(2S,3R)-2-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(4-methoxyphenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-chloro-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-bromo-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-iodo-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-methyl-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-cyano-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(methylthio)-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-thien-2-yl-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-thien-3-yl-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-pyridin-2-yl-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-pyridin-3-yl-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-phenyl-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(2-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(3-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(4-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(2-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(3-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(4-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(2-methylphenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(3-methylphenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(4-methylphenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(2-methoxyphenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(3-methoxyphenyl)-1H-pyrrole-1-carboxamide;    N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-3-(4-methoxyphenyl)-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-chloro-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-bromo-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-iodo-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-methyl-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-cyano-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-(methylthio)-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-thien-2-yl-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-thien-3-yl-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-pyridin-2-yl-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-pyridin-3-yl-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-phenyl-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-(2-fluorophenyl)-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-(3-fluorophenyl)-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-(4-fluorophenyl)-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-(2-chlorophenyl)-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-(3-chlorophenyl)-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-(4-chlorophenyl)-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-(2-methylphenyl)-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-(3-methylphenyl)-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-(4-methylphenyl)-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-(2-methoxyphenyl)-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-(3-methoxyphenyl)-1H-pyrrole-1-carboxamide;    Exo-4(S)-N-(1-azabicyclo[2.2.1]hept-3-yl)-3-(4-methoxyphenyl)-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-chloro-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-bromo-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-iodo-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-methyl-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-cyano-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-(methylthio)-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-thien-2-yl-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-thien-3-yl-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-pyridin-2-yl-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-pyridin-3-yl-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-phenyl-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-(2-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-(3-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-(4-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-(2-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-(3-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-(4-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-(2-methylphenyl)-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-(3-methylphenyl)-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-(4-methylphenyl)-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-(2-methoxyphenyl)-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-(3-methoxyphenyl)-1H-pyrrole-1-carboxamide;    N-(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl-3-(4-methoxyphenyl)-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-chloro-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-bromo-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-iodo-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-methyl-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-cyano-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-(methylthio)-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-thien-2-yl-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-thien-3-yl-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-pyridin-2-yl-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-pyridin-3-yl-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-phenyl-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-(2-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-(3-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-(4-fluorophenyl)-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-(2-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-(3-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-(4-chlorophenyl)-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-(2-methylphenyl)-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-(3-methylphenyl)-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-(4-methylphenyl)-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-(2-methoxyphenyl)-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-(3-methoxyphenyl)-1H-pyrrole-1-carboxamide;    N-1-azabicyclo[3.2.2]non-3-yl-3-(4-methoxyphenyl)-1H-pyrrole-1-carboxamide; or a pharmaceutically acceptable salt thereof.    
   
   
       12 . A pharmaceutical composition comprising a compound of  claim 1  and a pharmaceutically acceptable excipient.