Ocular compositions that increases the activity of gelatinase a in ocular cells

Abstract

Compositions capable of effecting a “pharmacological trabeculocanalotomy” in an eye by means of reducing juxtacanalicular meshwork as a barrier to outflow of aqueous. The small organic molecules increase Gelatinase A activity in ocular cells by increasing cell membrane expression of membrane-type matrix metalloproteinases (MT-MMPs) to increase aqueous outflow as a treatment for primary open angle glaucoma.

1 - 19 . (canceled)  
     
     
         20 . A pharmaceutically acceptable composition comprising: 
 a small-molecule, organic compound or hydrates and salts of the organic compound in a therapeutically effective amount to increase the activity of Gelatinase A in ocular cells; and    a pharmaceutically acceptable aqueous or non-aqueous carrier for delivery on or within the eye.    
     
     
         21 . A method of administering the pharmaceutically acceptable composition of  claim 20  comprising: 
 formulating said composition as a sterile aqueous or non-aqueous solution; and    applying said solution on or within an eye.    
     
     
         22 . A method of administering the pharmaceutically acceptable composition of  claim 20  comprising: 
 providing said composition in the form of an ocular implant; and    implanting said ocular implant within an eye.