US2006122100A1PendingUtilityA1

Melanin extinguisher

47
Assignee: OGA RES INCPriority: Sep 13, 2002Filed: Sep 11, 2003Published: Jun 8, 2006
Est. expirySep 13, 2022(expired)· nominal 20-yr term from priority
Inventors:Kazumi Ogata
A61P 43/00A61P 17/16A61K 31/4172A61K 31/28A61Q 19/02C07K 5/06113C07D 233/26C07D 213/75A61K 31/404C07D 209/14C07K 5/0606C07C 323/60A61K 8/46A61K 31/4402A61K 31/315A61P 17/00A61K 31/22C07C 323/52A61K 2800/51A61K 31/4015C07D 207/16A61K 31/185A61K 31/16C07D 339/02A61K 8/00
47
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Claims

Abstract

A melanin eliminator preparation comprising a metal chelate compound represented by the following formula (I), wherein M denotes a metal, and R denotes hydroxyl, O-lower alkyl, an amine bonded at N, an amino acid bonded at N, or a peptide bonded at N, or a pharmacologically acceptable salt thereof.

Claims

exact text as granted — not AI-modified
1 . A melanin eliminator preparation comprising a metal chelate compound represented by the following formula (I),  
     
       
         
         
             
             
         
       
     
     wherein M denotes a metal, and R denotes hydroxyl, O-lower alkyl, an amine bonded at N, an amino acid bonded at N, or a peptide bonded at N, or a pharmacologically acceptable salt thereof.  
   
   
       2 . The melanin eliminator preparation of  claim 1  wherein the metal chelate compound is 6,8-dimercaptooctanoic acid metal chelate compound.  
   
   
       3 . The melanin eliminator preparation of  claim 1  wherein the metal chelate compound is a 6,8-dimercaptooctanoic acid lower alkyl ester metal chelate compound.  
   
   
       4 . The melanin eliminator preparation of  claim 3  wherein the 6,8-dimercaptooctanoic acid lower alkyl ester metal chelate compound is a 6,8-dimercaptooctanoic acid ethyl ester metal chelate compound.  
   
   
       5 . The melanin eliminator preparation of  claim 1  wherein the metal chelate compound is a N-(6,8-dimercaptooctanoyl)amine metal chelate compound.  
   
   
       6 . The melanin eliminator preparation of  claim 5  wherein the N-(6,8-dimercaptooctanoyl)amine metal chelate compound is selected from the group consisting of 6,8-dimercaptooctanoic acid amide metal chelate, N-(6,8-dimercaptooctanoyl)-2-aminoethanol metal chelate, N-(6,8-dimercaptooctanoyl)isopropylamine metal chelate, N-(6,8-dimercaptooctanoyl)melatonin metal chelate, and N-(6,8-dimercaptooctanoyl)-2-aminopyridine metal chelate.  
   
   
       7 . The melanin eliminator preparation  claim 1  wherein the metal chelate compound is a N-(6,8-dimercaptooctanoyl)amino acid metal chelate compound.  
   
   
       8 . The melanin eliminator preparation of  claim 7  wherein the N-(6,8-dimercaptooctanoyl)amino acid metal chelate compound is selected from the group consisting of N-(6,8-dimercaptooctanoyl)-α-amino acid metal chelate, N-(6,8-dimercaptooctanoyl)-ω-amino acid metal chelate, and N-(6,8-dimercaptooctanoyl)-special amino acids metal chelate compound.  
   
   
       9 . The melanin eliminator preparation of  claim 8  wherein the N-(6,8-dimercaptooctanoyl)-α-amino acid metal chelate is selected from the group consisting of N-(6,8-dimercaptooctanoyl) glycine metal chelate, N-(6,8-dimercaptooctanoyl)alanine metal chelate, N-(6,8-dimercaptooctanoyl)threonine metal chelate, N-(6,8-dimercaptooctanoyl)serine metal chelate, N-(6,8-dimercaptooctanoyl)aspartic acid metal chelate, N-(6,8-dimercaptooctanoyl)glutamic acid metal chelate, N-(6,8-dimercaptooctanoyl)phenylalanine metal chelate, N-(6,8-dimercaptooctanoyl)methionine metal chelate, N-(6,8-dimercaptooctanoyl)norleucine metal chelate, N-(6,8-dimercaptooctanoyl)cysteine metal chelate, N-(6,8-dimercaptooctanoyl)hydroxyproline metal chelate, N-(6,8-dimercaptooctanoyl)histidine metal chelate, N-(6,8-dimercaptooctanoyl)-5-hydroxytryptophan metal chelate, N-(6,8-dimercaptooctanoyl)penicillamine metal chelate and N-(6,8-dimercaptooctanoyl)lysine metal chelate compounds.  
   
   
       10 . The melanin eliminator preparation of  claim 9  wherein the N-(6,8-dimercaptooctanoyl)-ω-amino acid metal chelate and the N-(6,8-dimercaptooctanoyl)special amino acid metal chelate compounds are selected from the group consisting of N-(6,8-dimercaptooctanoyl)-3-aminopropionic acid metal chelate, N-(6,8-dimercaptooctanoyl)-4-aminobutyric acid metal chelate, N-(6,8-dimercaptooctanoyl)-6-aminohexanoic acid metal chelate, N-(6,8-dimercaptooctanoyl)-4-trans-aminomethyl-1-cyclohexane carboxylic acid metal chelate, N-(6,8-dimercaptooctanoyl)-2-aminoethanesulfonic acid metal chelate, N-(6,8-dimercaptooctanoyl)sulfanilic acid metal chelate, N-(6,8-dimercaptooctanoyl)anthranilic acid metal chelate and N-(6,8-dimercaptooctanoyl)anthranilic acid ethyl ester metal chelate compounds.  
   
   
       11 . The melanin eliminator preparation  claim 1  the metal chelate compound is a N-(6,8-dimercaptooctanoyl)peptide metal chelate compound.  
   
   
       12 . The melanin eliminator preparation  claim 11  wherein the N-(6,8-dimercaptooctanoyl)peptide metal chelate compound is selected from the group consisting of N-(6,8-dimercaptooctanoyl)aspartylglycine metal chelate and N-(6,8-dimercaptooctanoyl)threonylglycine metal chelate.  
   
   
       13 . The melanin eliminator preparation of  claim 1  wherein the metal is zinc.  
   
   
       14 . The melanin eliminator preparation of  claim 1  wherein the preparation is a dermatological preparation for external use.  
   
   
       15 . The melanin eliminator preparation of  claim 14  wherein the preparation is a cosmetic preparation.  
   
   
       16 . A zinc chelate compound represented by the following formula (II),  
     
       
         
         
             
             
         
       
     
     wherein R denotes hydroxyl, O-alkyl, an amine bonded at N or a peptide bonded at N, or a pharmacologically acceptable salt thereof.  
   
   
       17 . The zinc chelate compound of  claim 16  wherein the compound is a 6,8-dimercaptooctanoic acid zinc chelate compound, or a pharmacologically acceptable salt thereof.  
   
   
       18 . A method for elimination of melanin comprising administering to a human an effective amount of a metal chelate compound represented by the following formula (I),  
     
       
         
         
             
             
         
       
     
     wherein M denotes a metal, and R denotes hydroxyl, O-lower alkyl, an amine bonded at N, an amino acid bonded at N or a peptide bonded at N, or a pharmacologically acceptable salt thereof.  
   
   
       19 . Use of a metal chelate compound represented by the following formula (I),  
     
       
         
         
             
             
         
       
     
     wherein M denotes a metal, and R denotes hydroxyl, O-lower alkyl, an amine bonded at N, an amino acid bonded at N or a peptide bonded at N, or a pharmacologically acceptable salt thereof for the manufacture of a melanin eliminating preparation.

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