Method of identifying changes in biopolymers

Abstract

The current invention relates to a method of identifying changes in biopolymers, especially in chromosomal DNA, using two or more different sets of labeled detector molecules, as well as to a diagnostic kit for detecting these changes.

1 - 14 . (canceled)  
     
     
         15 . A diagnostic kit for identifying changes in biopolymers comprising: 
 a first set of detector molecules labeled with a first label;    a second set of detector molecules labeled with a second label, said second label differing from said first label;    said first and second sets of detector molecules capable of forming bondings with biopolymers whereby evaluation of said bondings permits identification of changes in said biopolymers.    
     
     
         16 . The diagnostic kit according to  claim 15 , wherein said sets of detector molecules are capable of forming bondings with material selected from the group consisting of human chromosomal material and tumor material.  
     
     
         17 - 26 . (canceled)  
     
     
         27 . The diagnostic kit according to  claim 15 , further comprising calibrating probes.  
     
     
         28 . The diagnostic kit according to  claim 27 , further comprising calibrating probes for intensity standardization.  
     
     
         29 . The diagnostic kit according to  claim 27 , further comprising a sufficient number of said calibrating probes to enable a direct assignment of color bands to the ISCN nomenclature.  
     
     
         30 . The diagnostic kit according to  claim 27 , wherein said probes are simultaneously used for positional correction or intensity standardization.