Methods of delivering stable topical drug compositions

Abstract

A method of delivering a drug composition comprises providing a carrier having a phosphatidylcholine component and a drug entrapped therein, and applying the composition to the skin for transdermal delivery of the drug, wherein the composition is stable at room temperature.

1 . A method for administering a drug comprising applying to skin composition containing: 
 an effective amount of said drug,    a carrier having a phosphatidylcholine component entrapping said drug,    wherein said carrier stabilizes said drug at room temperature.    
     
     
         2 . The method of  claim 1 , wherein said phosphatidylcholine component comprises polyenylphosphatidylcholine and at least one polyglycol.  
     
     
         3 . The method of  claim 2 , wherein said polyglycol comprises polyglycol having a molecular weight of 200 and polyglycol having a molecular weight of 400.  
     
     
         4 . The method of  claim 3 , wherein said phosphatidylcholine component comprises 45% w/w polyenylphosphatidylcholine, 50% w/w polyglycol having a molecular weight of 200, and 5% w/w polyglycol having a molecular weight of 400.  
     
     
         5 . The method of  claim 1 , wherein said carrier comprises a surfactant, a lubricant, and methyl paraben.  
     
     
         6 . The method of  claim 4 , wherein said carrier comprises 97.25% w/w phosphatidylcholine component, 1.00% w/w surfactant, 1.00% w/w lubricant, and 0.75% methyl paraben.  
     
     
         7 . The method of  claim 4 , wherein said carrier further comprises water.  
     
     
         8 . The method of  claim 7 , wherein said carrier comprises 53.25% w/w phosphatidylcholine component, 1.00% w/w surfactant, 1.00% lubricant, 0.75% w/w methyl paraben and 45% w/w water.  
     
     
         9 . The method of  claim 5 , wherein said surfactant is a siloxylated polyether.  
     
     
         10 . The method of  claim 9 , wherein said siloxylated polyether is dimethyl, methyl(propylpolyethylene oxide propylene oxide, acetate) siloxane.  
     
     
         11 . The method of  claim 5 , wherein said lubricant is silicone fluid.  
     
     
         12 . The method of  claim 11 , wherein said silicone fluid contains low viscosity polydimethylsiloxane polymers.  
     
     
         13 . The method of  claim 1 , wherein said drug is selected from the group consisting of oxytocin, vasopressin, insulin, somatotropin, calcitonin, chorionic gonadotropin, menotropins, follitropins, somatostatins, progestins, and combinations of any of these.