US2006127474A1PendingUtilityA1

Pharmaceutical compositions comprising fluvastatin

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Assignee: KALB OSKARPriority: Apr 11, 2001Filed: Feb 3, 2006Published: Jun 15, 2006
Est. expiryApr 11, 2021(expired)· nominal 20-yr term from priority
Inventors:Oskar KalbStephen Valazza
A61K 31/225A61K 9/2054A61P 3/06
51
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Claims

Abstract

Pharmaceutical compositions comprising fluvastatin, HPMC and optionally other pharmaceutical excipients which are colour-stable upon prolonged periods of storage.

Claims

exact text as granted — not AI-modified
1 - 15 . (canceled)  
   
   
       16 . A color-stable sustained release pharmaceutical composition comprising fluvastatin, a hydroxypropyl methyl cellulose polymer, and a non-ionic hydrophilic polymer, wherein the non-ionic hydrophilic polymer is selected from the group consisting of hydroxyethylcellulose having a number average molecular weight of from about 90,000 to about 1,300,000, hydroxypropyl cellulose having a number average molecular weight of about 370,000 to about 1,500,000, and poly(ethylene) oxide having a number average molecular weight of about 100,000 to about 500,000.  
   
   
       17 . The composition according to  claim 16  wherein the hydroxypropyl methyl cellulose polymer has a number average molecular weight of about 20,000 to about 170,000.  
   
   
       18 . The composition according to  claim 17  wherein the hydroxypropyl methyl cellulose polymer comprises up to 12 percent hydroxypropyl functionality.  
   
   
       19 . The composition according to  claim 16  wherein the hydroxyethylcellulose has a number average molecular weight of from about 1,000,000 to about 1,300,000.  
   
   
       20 . The composition according to  claim 16  wherein the hydroxypropyl cellulose has a number average molecular weight of about 850,000 to about 1,200,000.  
   
   
       21 . The composition according to  claim 16  wherein the poly(ethylene) oxide has a number average molecular weight of about 150,000 to about 300,000.  
   
   
       22 . The composition according to  claim 16  wherein the weight ratio of hydroxypropyl methyl cellulose to non-ionic hydrophilic polymer is from about 10:1 to about 3:1.  
   
   
       23 . The composition according to  claim 22  wherein the weight ratio of hydroxypropyl methyl cellulose to non-ionic hydrophilic polymer is from about 7:1 to about 5:1.  
   
   
       24 . The composition according to  claim 23  wherein the weight ratio of hydroxypropyl methyl cellulose to non-ionic hydrophilic polymer is about 6:1.  
   
   
       25 . The composition according to  claim 16  in the form of an oral dosage form.  
   
   
       26 . The composition according to  claim 16  in the form of granules.  
   
   
       27 . The composition according to  claim 16  in the form of a tablet.  
   
   
       28 . The composition according to  claim 16  wherein the fluvastatin is fluvastatin sodium.

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