Dried product and a process for manufacturing the product

Abstract

A dried product of an extract from inflammatory rabbit skin inoculated with vaccinia virus having an inhibitory activity for the production of a kallikrein-like substance is produced by admixing the extract with a saccharide, sugar alcohol or ascorbic acid before reaching dryness, and then drying the admixture to a solid form such as granules. The dried product may be employed to produce a solid preparation for oral administration, such as tablets, having an inhibitory activity for the production of a kallikrein-like substance.

1 . A process for the manufacture of a dried product of an extract from inflammatory rabbit skin inoculated with vaccinia virus comprising admixing said extract with at least one member selected from the group consisting of saccharides, sugar alcohols, and ascorbic acid to obtain a mixture, and then drying the mixture to obtain a dried product.  
   
   
       2 . A process as claimed in  claim 1  where the dried product has an inhibitory activity for the production of a kallikrein-like substance.  
   
   
       3 . A process as claimed in  claim 1  wherein a saccharide, sugar alcohol or ascorbic acid is added to and mixed with an extract from inflammatory rabbit skin inoculated with vaccinia virus and then the mixture is concentrated and dried.  
   
   
       4 . A process as claimed in  claim 1  wherein an extract from inflammatory rabbit skin inoculated with vaccinia virus is concentrated and, before the concentrated extract reaches dryness, a saccharide, sugar alcohol or ascorbic acid is added thereto and mixed therewith and then the mixture is dried.  
   
   
       5 . A process as claimed in  claim 3  wherein concentration and drying of said extract is carried out at a pH of less than or equal to 10.  
   
   
       6 . A process as claimed in  claim 3  wherein concentration and drying of said extract is carried out at a pH of 8.5 to 9.7.  
   
   
       7 . A process as claimed in  claim 1  wherein said at least one member comprises at least one saccharide selected from the group consisting of glucose, mannose, arabinose, xylose, galactose, sorbose, lactose, sucrose, maltose, raffinose, melezitose, pullulan, dextrin, β-cyclodextrin and dextran.  
   
   
       8 . A process as claimed in  claim 1  wherein said at least one member comprises at least one sugar alcohol selected from the group consisting of mannitol, maltitol, lactitol, palatinit and sorbitol.  
   
   
       9 . A process as claimed in  claim 1  wherein the amount of said at least one member is at least 0.1% by weight, based upon the weight of the extract and said at least one member.  
   
   
       10 . A process as claimed in  claim 1  wherein said drying comprises vacuum drying.  
   
   
       11 . A process as claimed in  claim 1  wherein said mixture is granulated and dried to obtain granules.  
   
   
       12 . A process as claimed in  claim 11  wherein said granules are formed into tablets.  
   
   
       13 . A process as claimed in  claim 12  wherein said tablets are spray coated with a coating solution.  
   
   
       14 . A dried product obtained by the process of  claim 1 .  
   
   
       15 . A dried product as claimed in  claim 14  where the dried product has an inhibitory activity for the production of a kallikrein-like substance.  
   
   
       16 . A solid preparation for oral administration comprising a dried product of  claim 14 .  
   
   
       17 . A dried product having an inhibitory activity for the production of a kallikrein-like substance comprising a co-dried admixture of an extract from inflammatory rabbit skin inoculated with vaccinia virus and at least one member selected from the group consisting of saccharides, sugar alcohols and ascorbic acid.  
   
   
       18 . A dried product as claimed in  claim 17  wherein said at least one member comprises at least one saccharide selected from the group consisting of glucose, mannose, arabinose, xylose, galactose, sorbose, lactose, sucrose, maltose, raffinose, melezitose, pullulan, dextrin, β-cyclodextrin and dextran.  
   
   
       19 . A dried product as claimed in  claim 17  wherein said at least one member comprises at least one sugar alcohol selected from the group consisting of mannitol, maltitol, lactitol, palatinit and sorbitol.  
   
   
       20 . A solid preparation for oral administration comprising granules of a dried product as claimed in  claim 17 .  
   
   
       21 . A solid preparation for oral administration as claimed in  claim 20 , wherein the preparation is a tablet.  
   
   
       22 . A solid preparation having an inhibitory activity for the production of a kallikrein-like substance for oral administration comprising an extract from inflammatory rabbit skin inoculated with vaccinia virus as an effective ingredient which is manufactured using dried granules prepared in such a manner that said extract is concentrated and, before said extract reaches dryness, an excipient comprising at least one member selected from the group consisting of saccharides, sugar alcohols and ascorbic acid is added thereto and kneaded therewith, and then the kneaded mixture is granulated and dried.