Method for treatment of HIV infection

Abstract

A method for treatment of HIV infection includes administering at least one anti-HIV drug, such as a reverse transcriptase inhibitor, to a patient in need of such treatment and administering an extract from inflammatory tissue inoculated with vaccinia virus to the patient following the administration of the at least one anti-HIV drug. The extract maintains suppressive action on HIV replication, even if the administration of the anti-HIV drug is terminated.

1 . A method for treatment of HIV infection comprising: 
 administering at least one anti-HIV drug to a patient in need of such treatment; and    administering an extract from inflammatory tissue inoculated with vaccinia virus to the patient following the administration of the at least one anti-HIV drug.    
   
   
       2 . A method according to  claim 1  wherein the at least one anti-HIV drug is at least one drug selected from the group consisting of nucleoside/nucleotide reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, protease inhibitors, and fusion inhibitors.  
   
   
       3 . A method according to  claim 1  wherein the at least one anti-HIV drug comprises a reverse transcriptase inhibitor.  
   
   
       4 . A method according to  claim 3  wherein the reverse transcriptase inhibitor is at least one member selected from the group consisting of Abacavir (ABC), Didanosine (ddI), Emtricitabine (FTC), Lamivudine (3TC), Stavudine (d4T), Tenofovir (TDF), Zalcitabine (ddC), Zidovudine (AZT), Delavirdine (DLV), Efavirenz (RFV), and Nevirapine (NVP).  
   
   
       5 . A method according to  claim 1  wherein the inflammatory tissue comprises skin tissue of a rabbit.  
   
   
       6 . A method according to  claim 1  wherein viral loads of HIV in the blood of the patient are lowered by administration of the at least one anti-HIV drug.  
   
   
       7 . A method according to  claim 1  wherein the plasma viral level of HIV-RNA is lowered to less than a detectable level by the administration of at least one anti-HIV drug.  
   
   
       8 . A method according to  claim 1  wherein the administration of at least one anti-HIV drug is terminated and the extract maintains suppressive action on HIV replication.  
   
   
       9 . A method for treatment of HIV infection comprising the administration of an extract from inflammatory tissue inoculated with vaccinia virus to a patient in need of such treatment after viral loads of HIV in blood are lowered by the administration of at least one anti-HIV drug, or after the plasma viral level of HIV-RNA is lowered to less than a detectable limit by the administration of at least one anti-HIV drug.  
   
   
       10 . A method according to  claim 9  wherein the administration of an extract from inflammatory tissue inoculated with vaccinia virus to a patient in need of such treatment is after the plasma viral level of HIV-RNA is lowered to less than a detectable limit by the administration of at least one anti-HIV drug.  
   
   
       11 . A method according to  claim 9  wherein the inflammatory tissue is skin tissue of rabbit.  
   
   
       12 . A method according to  claim 9  wherein the at least one anti-HIV drug comprises a reverse transcriptase inhibitor.  
   
   
       13 . A method according to  claim 10  wherein the inflammatory tissue is skin tissue of rabbit.  
   
   
       14 . A method according to  claim 10  wherein the at least one anti-HIV drug comprises a reverse transcriptase inhibitor.  
   
   
       15 . A method according to  claim 9  wherein said at least one anti-HIV drug comprises at least one member selected from the group consisting of Abacavir (ABC), Didanosine (ddI), Emtricitabine (FTC), Lamivudine (3TC), Stavudine (d4T), Tenofovir (TDF), Zalcitabine (ddC), Zidovudine (AZT), Delavirdine (DLV), Efavirenz (RFV), Nevirapine (NVP), Amprenavir (APV), Atazanavir (ATV), Indinavir (IDV), Ritonavir (RTV), Lopinavir/Ritonavir (LPV/RTV), Nelfinavir (NFV), Saquinavir (SQV), and Enfuvirtide (T20)  
   
   
       16 . A method for treatment of HIV infection comprising reducing the viral load of HIV in the blood or reducing the plasma viral level of HIV-RNA in a patient by the administration of a pharmaceutically effective amount of at least one anti-HIV drug, and administering a pharmaceutically effective amount of an extract from inflammatory tissue inoculated with vaccinia virus while said viral load of HIV or viral level of HIV-RNA is reduced.  
   
   
       17 . A method according to  claim 16  wherein said extract is administered during and after treatment with said at least one anti-HIV drug.  
   
   
       18 . A method according to  claim 16  wherein said administration of said extract is initiated just prior to termination of treatment with said at least one anti-HIV drug.  
   
   
       19 . A method according to  claim 16  wherein said administration of said extract is initiated after termination of treatment with said at least one anti-HIV drug.  
   
   
       20 . A method according to  claim 16 , wherein said administration of said extract is initiated when the plasma viral level of HIV-RNA is lowered to less than a detectable limit by administration of the at least one anti-HIV drug, the inflammatory tissue is skin tissue of rabbit, and the anti-HIV drug comprises a reverse transcriptase inhibitor.