US2006140866A1PendingUtilityA1

Agents for treating neurodegenerative disorders

Individually held — no corporate assignee on recordPriority: Oct 23, 1995Filed: Feb 24, 2006Published: Jun 29, 2006

Est. expiryOct 23, 2015(expired)· nominal 20-yr term from priority

Inventors:Nikolai Zefirov Andrei Afanasiev Svetlana Afanasieva Sergei Bachurin Sergei Tkachenko Vladimir Grigoriev Marina Jurovskaya Valery Chetverikov Elizaveta Bukatina Irina Grigorieva

A61K 31/437A61K 49/006A61P 25/28

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Abstract

Compounds and methods of using these compounds to treat neurodegenerative diseases, especially Alzheimer's disease, are provided. The compounds that are provided for the treatment of neurodegenerative diseases can be represented by a general formula (I): wherein R 1 is Me, Et or PhCH 2 ; R 2 is H, PhCH 2 or 6-Me-3-Py-(CH 2 ) 2 ; and R 3 is H, Me or Br. The solid line accompanied by the dotted line i.e. represents a single or double bond and salts thereof with pharmacologically acceptable acids and quaternary derivatives.

Claims

exact text as granted — not AI-modified

1 . A method of measuring the accuracy of NMDA injection into a mouse brain comprising co-injecting methylene blue and NMDA into the mouse brain and monitoring the migration of methylene blue.

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