Composition of biochemical compounds involved in bioenergy metabolism of cells and method of use

Abstract

A composition of biochemical compounds involved in bioenergy metabolism of cells and a method of use in prevention and therapy of diseases are disclosed.

1 - 22 . (canceled)  
   
   
       23 . A method for improving bioenergy metabolism of cells comprising administering to a human a composition which comprises a pharmaceutically acceptable carrier; and  
     
       
         
               
               
               
             
                   
                   
               
                   
                   
               
                   
                 Biochemical Substances 
                 Amount 
               
                   
                   
               
                   
               
               
               
               
               
             
                   
                 Succinate 
                 0.01-100 
                 mg; 
               
                   
                 Fumarate 
                 0.01-100 
                 mg; 
               
                   
                 L-Malate 
                 0.01-100 
                 mg; and 
               
                   
                 α-Ketoglutarate 
                 0.01-100 
                 mg. 
               
                   
                   
               
                   
                   
               
           
              
              
              
              
             
             
              
             
          
           
              
              
              
              
              
              
             
          
         
       
     
   
   
       24 . A method for improving bioenergy metabolism of cells comprising administering to a human a composition which comprises a pharmaceutically acceptable carrier; and  
     
       
         
               
               
               
             
                   
                   
               
                   
                   
               
                   
                 Biochemical Substances 
                 Amount 
               
                   
                   
               
                   
               
               
               
               
               
             
                   
                 Pyruvate 
                 0.01-100 
                 mg; 
               
                   
                 Acetyl -Coenzyme a 
                 0.01-100 
                 mg; 
               
                   
                 Citrate 
                 0.01-200 
                 mg; 
               
                   
                 Cis-Aconitate 
                 0.01-100 
                 mg; 
               
                   
                 Isocitrate 
                 0.01-100 
                 mg; 
               
                   
                 Oxalosuccinate 
                 0.01-100 
                 mg; 
               
                   
                 2-Oxo-Glutarate 
                 0.01-100 
                 mg; 
               
                   
                 Succinyl- 
                 0.01-100 
                 mg; 
               
                   
                 Coenzyme A and 
               
                   
                 Oxaloacetate 
                 0.01-100 
                 mg. 
               
                   
                   
               
                   
                   
               
           
              
              
              
              
             
             
              
             
          
           
              
              
              
              
              
              
              
              
              
              
              
              
             
          
         
       
     
   
   
       25 . A method for improving bioenergy metabolism of cells comprising administering to a human a composition which comprises a pharmaceutically acceptable carrier; and  
     
       
         
               
               
               
             
                   
                   
               
                   
                   
               
                   
                 Biochemical Substances 
                 Amount 
               
                   
                   
               
                   
               
               
               
               
               
             
                   
                 Lipoic Acid 
                 0.01-100 
                 mg; 
               
                   
                 Lipoamide (Lipoic Acid + Lysine); 
                 0.01-100 
                 mg 
               
                   
                 Acetyl-Lipoamide 
                 0.01-100 
                 mg; 
               
                   
                 Lysine 
                 0.01-100 
                 mg; 
               
                   
                 Carnitine 
                 0.01-100 
                 mg; 
               
                   
                 Ascorbate 
                 0.01-200 
                 mg; 
               
                   
                 Thiamine 
                 0.01-10 
                 mg; 
               
                   
                 Riboflavin 
                 0.01-10 
                 mg; 
               
                   
                 Nicotinic Acid 
                 0.01-10 
                 mg; 
               
                   
                 Niacinamide 
                 0.01-10 
                 mg; 
               
                   
                 Pantothenate 
                 0.01-10 
                 mg; 
               
                   
                 Nicotinamide-Adenine 
                 0.01-10 
                 mg; 
               
                   
                 Dinucleotide (NAD) 
               
                   
                 Reduced Nicotinamide 
                 0.01-10 
                 mg; 
               
                   
                 Adenine 
               
                   
                 Dinucleotide 
               
                   
                 Nicotinamide-Adenine 
                 0.01-10 
                 mg; 
               
                   
                 Dinucleotide 
               
                   
                 Phosphate (NADP) 
               
                   
                 reduced NADP (NADPH) 
                 0.01-10 
                 mg; 
               
                   
                 Quinolinate 
                 0.01-10 
                 mg; 
               
                   
                 (NAD/NADP precursor) 
               
                   
                 Flavin-Adenine 
                 0.01-10 
                 mg; 
               
                   
                 Dinucleotide (FAD) 
               
                   
                 Reduced Flavin-Adenine 
                 0.01-10 
                 mg; 
               
                   
                 Dinucleotide (FADH) 
               
                   
                 Flavin Mononucleotide 
                 0.01-10 
                 mg; 
               
                   
                 (FMN) 
               
                   
                 Reduced Flavin 
                 0.01-10 
                 mg; 
               
                   
                 Mononucleotide (FMNH 2 ) 
               
                   
                 Adenosine, Diphosphate 
                 0.01-10 
                 mg; 
               
                   
                 (ADP) 
               
                   
                 Adenosine, Triphosphate 
                 0.01-10 
                 mg; 
               
                   
                 (ATP) 
               
                   
                 Guanosine Diphosphate 
                 0.01-10 
                 mg; 
               
                   
                 (GDP) 
               
                   
                 Guanosine Triphosphate 
                 0.01-10 
                 mg; 
               
                   
                 (GTP) 
               
                   
                 Magnesium (Mg 2+ ) 
                 0.01-10 
                 mg; 
               
                   
                 Calcium (Ca 2+ ) 
                 0.01-10 
                 mg; 
               
                   
                 Manganese (Mn 2+ ) 
                 0.01-10 
                 mg; 
               
                   
                 Copper 
                 0.01-10 
                 mg; 
               
                   
                 Iron-Sulfate 
                 0.01-10 
                 mg; and 
               
                   
                 Molybdenum 
                 0.01-10 
                 mg.